Don’t forget to send reform leaflets back.
It costs them £2.50 a pop.

Alu-mediated RNA duplexes are associated with widespread exon skipping across primate transcriptomes - Genome Biology Alternative splicing patterns have diverged rapidly during vertebrate evolution. By integrating genome-wide predictions of stable RNA duplexes, alternative splicing profiles, and proximity ligation-de...

link.springer.com/article/10.1...

My first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances!

He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding.

See more details in EMBL post below!

The science should matter and not whether it is Drosophila or some other model organism as some impact addicted journals desk reject on this object or whether you already published with them.
We need more eLife's!

Well, I am worried about the ignorance of the fundamental discoveries that have been made in model organisms.
It has become almost impossible to get funding for using yeast as model.

I'll join. Miserable times.

New research reveals how development and sex shape the brain | Two companion studies, published in Cell Genomics, reveal how brain development lays the foundation for both shared and sex-specific circuits, redefining how neural diversity arises. A preview

Proud to share that our team made the local news. A big congratulations to Erin, Megan, and everyone on the team who made it happen.Thanks to Ben Hopkins and Artyom Kopp for the Preview piece.

www.ox.ac.uk/news/2026-03...

Aging ribosomes - see a very cool story here:
www.biorxiv.org/content/10.6...

m6A is the most common internal mRNA modification, but we still don't know what most m6A sites actually DO.

Zhang et al. built FOCAS -- a CRISPR-based platform using dCas13b-FTO to precisely remove m6A at specific sites without touching the DNA.

doi.org/10.1016/j.c...

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

🎉Excited to share our latest paper, published in Nature Communications!🎉

"Enhancing autophagy by redox regulation extends lifespan in Drosophila"

#redox #metabolism #ageing #Drosophila

@natcomms.nature.com @mrc-lms.bsky.social

doi.org/10.1038/s414...

Deltaviruses spread through a viral Trojan Horse Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it.
A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

After 5 years of developing, a new preprint from the lab - introducing our workflow for comparative insect connectomics, aimed at democratizing connectomics. @erc.europa.eu @lundvision.bsky.social @biologylu.bsky.social Read it here: www.biorxiv.org/content/10.6...

Small‐Molecule Activation of mRNA Translation by Click‐to‐Release Reaction in Cells A new method to control mRNA activity using bioorthogonal click-to-release reactions is presented. The 5′ cap is modified with a trans-cyclooctene (TCO) that quickly reacts with hydroxyaryl-tetrazine...

Pleased to share our latest work: onlinelibrary.wiley.com/doi/10.1002/... in @angewandtechemie.bsky.social.

A symbiotic origin of the ribosome? Abstract. The origin of life is one of the great mysteries of science. Of the multiple unsolved problems, the origin of the translation system (the means b

Was the ribosome originally a parasite? Seems fantastical to me. academic.oup.com/pnasnexus/ar...

I once saved one trapped in a fence - lovely birds.

Excellent work, but what a pity - no speckles in flies!

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.

Nuclear speckles enable processing of RNA from GC-rich isochores Nuclear speckles are key subnuclear structures that regulate gene expression in GC-rich regions. This work shows that the evolution and expansion of core speckle proteins were crucial for the increase...

The function of nuclear speckles is revealed! This is an incredibly important paper with absolutely beautiful data! Wow! www.cell.com/cell/fulltex...

Amen 🙏🏻 🤲🏻
A wise person once told me "all antibodies are non-specific until proven otherwise" I was just telling this to my students today 🤯

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...

RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP

Early-bird registration discounts for CRISPR 2026 expire Feb 28. CRISPR 2026, held at Yale University, June 10 - 12, is the continuation of the original CRISPR meeting established in 2008.

Register here: web.cvent.com/event/ac20b6...

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...

Hibernating ribosomes - Molecular insights on discoveries from the 1960ies

www.science.org/doi/10.1126/...

UKRI CEO updates the research community on areas of uncertainty Following an open letter of 1 February, Sir Ian Chapman responds to feedback and provides an update.

For those following the developments of research funding in the UK, here is another letter from Ian Chapman about UKRI:
www.ukri.org/news/ukri-ce...

Research Fellow at University of Birmingham Discover Research Fellow jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.

We are hiring 2 Postdoctoral fellows for our lab (www.mueller-lab.org): 1, Transcription control of metabolic adaptation in development (shorturl.at/oeG6U).
2, Semantic rules of developmental gene regulation (shorturl.at/KdHmJ)
#jobs #transcription #zebrafish #zebrafishrock #IZFS

Structures of viral 4E bound to modified mRNA 5' caps including 2`O-ribose methylation - very nice work!

Using our bee-tracking drone, we discovered that honey bees 🐝 have highly precise and individual routes. Now published at @currentbiology.bsky.social : doi.org/10.1016/j.cu...

Our new preprint is out!

A state-dependent neural circuit resolves approach–avoidance conflicts

www.biorxiv.org/content/10.6...

Fantastic work led by Devika Bodas, with key contributions from Marine Balcou, and a great collaboration with Lisa Scheunemann Lab, fearuting Şevval Demirci.

as SPSN lines also express in a few neurons in the brain that can induce a sex peptide response.

Sex Peptide Response Inducing Neurons (SPRINz) in the brain, not SPSN in the genital tract induce post-mating responses from membrane-tethered sex peptide expression.

but SPSN express in a few neurons in the brain that can induce a sex peptide response.