@inserm.fr @cnrs.fr @cnrsbiologie.bsky.social @igbmc.bsky.social @frm-officiel.bsky.social @fondationarc.bsky.social

🚨paper alert 🚨 Our manuscript on targeting hypoxic signaling in metastatic and castration-resistant prostate cancer is out in @springernature.com Cell Death & Disease.

www.nature.com/articles/s41...

congratulations Pietro!!!

Nobel Laureate Professor Sir John Gurdon dies aged 92 It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

Sad to hear about the passing of John Gurdon, a titan and pioneer of developmental biology and much more. Winner of the Nobel Prize in Medicine or Physiology, shared with Shinya Yamanaka, who actually was inspired by his work
www.cam.ac.uk/research/new...

Are 90% of cancer-related deaths due to metastasis? Apparently the overuse of this percentage in reviews has created confusion and questioning of whether this is true. The answer, which is as always cancer type dependent, may be in these references that also people claim they cannot find.

Characterization of the immune landscape in healthy mouse prostate and during prostate cancer progression The immune landscape of healthy prostate and its alterations during prostate cancer (PCa) progression remain poorly characterized. Using scRNA-sequencing and multiparametric flow-cytometry analysis...

Thrilled to share our recent study on prostate immune landscape 🎉 #Prostate #Cancer #Macrophages #Neutrophils. doi.org/10.1080/2162... Thanks to my amazing group at @ciml.bsky.social @inserm.fr Despoina Pervizou & Joanna De Chiara 🔥 Thanks to our great collaborators @igbmc.bsky.social 🙏🏻

Excited to announce that I defended my PhD thesis, culminating the last 4 years of work in the @igbmc.bsky.social . A heartfelt thank you to my supervisor @metzgerlab.bsky.social , the jury members @mariannakruithof.bsky.social @marinelab.bsky.social and all those who supported me along the way.

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis.
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com

An avant-première presentation of a new study by @marinelab.bsky.social at the #EACR2025 on immunosuppressive NK cells in melanoma

See you tomorrow at the #EACR2025 poster session to discuss about hypoxia and myeloid cells in prostate cancer! @helloeacr.bsky.social

Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis The transition from benign to malignant growth is a pivotal yet poorly understood step in cancer progression that marks the shift from a pathologically inert condition to a clinically lethal disease. ...

Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis

www.biorxiv.org/content/10.1...

got to see it irl :) great talk of @ardemp.bskyverified.social at @unistra.fr

Mon Semi-Marathon pour la recherche sur le cancer ! Chers amis, cher réseau,Je me lance le défi de courir le Semi de Paris 2026, que j'aimerais courir avec un Dossard Solidaire pour la Fondation ARC, pour la recherche sur le cancer.Cette association so...

I will once again run for cancer research, this time with @fondationarc.bsky.social for Paris half-marathon 2026!
Je cours pour la Fondation ARC le 8 mars 2026, vous pouvez soutenir ma course en faisant un don pour la recherche sur le cancer:
semi-paris.dossards-solidaires.org/fundraisers/...

Great time at the CRCL symposium! It was a real pleasure to present our work (available here lnkd.in/dS254Hrz ) and to discuss. Thank you for such a warm welcome and for the poster prize by @fondationarc.bsky.social!

Daniel Metzger doing an overview of our lab’s research on prostate cancer at the #CRCL symposium in Lyon.

Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial - Nature Medicine This proof-of-concept phase 1 trial shows that the size of circulating tumor cell clusters (which can promote metastatic spread) can be reduced by treatment with the Na+/K+ ATPase inhibitor digoxin in...

on this paper in Nature Medicine www.nature.com/articles/s41...

Thank you to @frm-officiel.bsky.social for supporting the 4th year of my PhD, and @cnrsbiologie.bsky.social, @inserm.fr, @unistra.fr, @fondationarc.bsky.social for supporting this project. @igbmc.bsky.social

A great heartfelt thank you to the people who mentored and guided me through this project @metzgerlab.bsky.social @gilleslaverny.bsky.social and @beatrizgerman.bsky.social and to our great collaborators @sandrine-henri.bsky.social and Le Magnen lab.

Altogether, we uncovered that prostate tumor heterogeneity and plasticity might arise early during tumorigenesis in a localized manner as a result of bidirectional communication between cancer cells and their microenvironment. Targeting these interactions might limit cancer progression.

Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease Nature Communications - The molecular and cellular underpinnings of cribriform prostate cancer aggressiveness remain to be explored. Here, the authors perform single-cell RNA-sequencing, TCR...

Importantly, we found that our EMT cell population transcriptomic profile is similar to that of MSPC described by Han and colleagues doi.org/10.1016/j.ce... and might arise in other intraductal prostate tumors rdcu.be/d7yLi

Using organoid cultures, we validated that IL6 produced by CAFs is sufficient and necessary to induce EMT-like phenotype in PTEN- and p53-deficient tumor cells.

Our single-cell analyses identified a novel luminal cell population with EMT and cell plasticity characteristics that was driven by Stat3 signaling and we identified CAFs as sources of IL6 that would induce Stat3 in tumor cells.

To answer this, we used genetically-engineered mouse models that presented heterogeneous tumor development: while some presented intraductal and invasive tumors, others additionally developed hepatic micrometastases.

In this study, we wanted to address the question of what drives the heterogeneity of prostate tumor progression in PTEN- and p53-deficient tumors, and especially, how such tumors progress to metastases, the leading cause of prostate-cancer related deaths.

p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment Cell Death & Disease - p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment

Extremely happy to share that a part of my PhD project just got published in Cell Death and Disease rdcu.be/d7x68
In this work, we uncover how prostate tumor microenvironment drives tumor cell plasticity

"Adaptations of #neutrophils in #cancer"

Ng et al, 2025

A great new review on these fascinating immune cells!

In the first #Immunity issue of this year - with lots of other amazing immunology 🧪 check it out 🤩

@cp-immunity.bsky.social

www.cell.com/immunity/iss...

www.cell.com/immunity/abs...

Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity - Nature Communications Super-enhancers (SEs) drive specific gene expression programmes underlying different cancer cell states offering opportunities for therapeutic targeting. Here, the authors suggest targeting SE-depende...

Finally out our work showing the specific inhibition of melanoma-lineage identity genes using a new generation of ecteinascidin. Kudos to the only one Frédéric Coin and collaborators!
www.nature.com/articles/s41...

Now online in Cancer Discovery: Chronic #ViralMimicry Induction Following #p53 Loss Promotes Immune Evasion - by @cishak.bsky.social, Sajid Marhon, @daniel-decarvalho.bsky.social, and colleagues @pmresearch-uhn.bsky.social @mdanderson.bsky.social doi.org/10.1158/2159...

Lovely Christmas party with the group after such an amazing year! 🎄🎅Hope the best is to come next year Thanks to the Secret Santa 😜

congrats Gizem!