CenSpark story is now published in @natchembio.nature.com. We engineered a dual-ligand fluorescent probe to selectively "light up" centrioles & cilia. Massive thank to Pierre Gönczy, @lreymond.bsky.social and @ghatzopoulos.bsky.social for the guidance. Check it out 👉: doi.org/10.1038/s415...
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
We made a tool for generating seam-corrected microtubule reconstructions using CryoSPARC - please check it out! www.biorxiv.org/content/10.6...
Single-Cell Parameter Inference Reveals Kinetic Heterogeneity in Synthetic Mammalian Gene Expression: Biophysical Journal www.cell.com/biophysj/ful...
Xiaofeng combined 2D live-cell single-particle tracking with 3D simulations to specifically measure the bacterial nucleoid accessibility and viscosity! Our preprint describes how these nucleoid properties respond to cellular processes! Code is available too.
www.biorxiv.org/content/10.6...
New paper from @zhixingchen2.bsky.social's lab!
It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime!
www.nature.com/articles/s41...
@simonecoppola.bsky.social has made micromorph, the first native Python application and library for measuring bacterial morphology. It runs interactively in napari or can be easily integrated into automated Python scripts. It integrates deep learning cell segmentation and is easily extended 🔬🦠🧫
Huge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...
Ken A. Dill to Receive Biophysical Society’s 2026 Founders Award buff.ly/OZ3VUIk
Stony Brook’s Laufer Center for Physical & Quantitative Biology invites applications for an endowed faculty position (assistant/ associate professor). Join a top interdisciplinary hub in quantitative biology! Apply by Dec 1: apply.interfolio.com/173357
Megan Elizabeth Kelley, PhD Sfeir Lab/ Molecular Biology Losing our edge: Combating drug resistance in cancer
It’s SHOW TIME! 🎤 Kicking off the MSK Postdoc Slam is @meganekelley.bsky.social from the @agnelsfeir.bsky.social lab, diving into how error-prone DNA repair fuels drug resistance in cancer 🧬💊
Microscopy Training Grants Supporting microscopy training for early-career researchers in cell biology Apply for a grant of up to £1,000 Cartoon of a person looking down a microscope, which is next to a computer Journal of Cell Science logo and FocalPlane logo
📢Last few days to apply for this round of our #microscopy training grants with @jcellsci.bsky.social
Available to ECRs working on #cellbio to attend a microscopy or bioimage analysis training course.
Apply by 5 September
www.biologists.com/grants/jcs-f...
New preprint online!
So much fun working on this project, thank you @centriolelab.bsky.social and @dudinlab.bsky.social for embarking me on this one!
Hopefully HAK-actin will become your best companion for actin staining U-ExM expanded samples.
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Hey #biology #postdocs out there, are you worried about the academic job market in the current climate? Do not! We are hiring, and we are an absolutely AWESOME department! 🧪
Apply now: www.stonybrook.edu/commcms/bioc...
A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)
Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...
We've developed a single-molecule imaging approach to study how #influenza A viruses interact with live cells at the nanoscale. We found that cellular receptors show a specific organization and turnover at the virus-cell interface. 👉 www.nature.com/articles/s41...
@combinemarvproject.bsky.social
In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...
New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...
Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.
www.biorxiv.org/content/10.1...
