Picture/Art Credit @Roberta Florea

How do cells integrate multiple signals into precise responses? Our study uncovers neuronal calcium sensor proteins as new regulators of adenylyl cyclase 8, linking GPCR-cAMP-Ca²⁺ signaling. @rflorea.bsky.social @dina-sch.bsky.social @psi.ch @eth-dbiol.bsky.social
www.biorxiv.org/content/10.6...

Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration We are excited to announce the early-stage release of our S. cerevisiae  structural interactome mapping project. Using AlphaFold3 (AF3), w...

We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations.
www.evocellnet.com/2026/03/mapp...

Congratulations!!! Well deserved 🥳

Excited to share our new paper and lipid- and protein-directed photocatalytic labeling method (POCA) just out in @natchembio.nature.com. tinyurl.com/2kcxuvvv. Big congrats to first author Andrew Becker and the whole team for launching our lab into the wild world of singlet oxygen interactomics.

We’re delighted to report a global structural proteome analysis within living cells!

doi.org/10.1038/s443...

#proteomics #structuralproteomics #massspectrometry #structuralbiology #ethz @imsb-eth.bsky.social

Chemoproteomics Group at the Nucleus, Sarafan ChEM-H The Chemoproteomics Group at the Nucleus, Sarafan ChEM-H, led by Dr. Dina Schuster, focuses on a wide range of mass spectrometry-based techniques to study proteins and their molecular interactions.…

#ICYMI The Chemoproteomics Group at the Nucleus, led by @dina-sch.bsky.social, uses mass spec-based techniques to study proteins & their molecular interactions. The group supports Stanford researchers throughout a project, from design consultation to data analysis.

Computational design of conformation-biasing mutations to alter protein functions Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...

Can we design mutations that bias proteins towards desired conformational states?

Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc

Come and join us @stanford-chemh.bsky.social! It's an amazing place to do interdisciplinary science & I'm so grateful to be in this community. Faculty applications due 10/15/2025 -- please share widely. Interested but not sure you're ready to apply this year? DM me & I'm happy to provide advice :)

Sarafan ChEM-H awards four $25K seed grants to fund collaborations with the new chemoproteomics group at the Nucleus The grants will give researchers access to advanced instrumentation and technical guidance for a variety of specialized proteomics techniques.

Sarafan ChEM-H awards four $25K seed grants to fund collaborations w/ the new chemoproteomics group, led by @dina-sch.bsky.social at the Nucleus, a collection of labs that leverage scientific experts& advanced instrumentation to facilitate discoveries @stanford.edu chemh.stanford.edu/news/sarafan...

Come work with us at the Nucleus @stanford-chemh.bsky.social!

Happy to help you with proteome analyses, identifying your drug targets, understanding drug mechanisms, and much more 🔎🕵🏻

‼️ Job alert 🚨: I have an open 3-year postdoc position in my lab to develop novel crosslinking mass spectrometry workflows. 🧪🧪 So if you want to do cool stuff in protein MS, please apply ! ⬇️ Please RT
www.verwaltung.uni-halle.de/dezern3/Auss...

#Academicsky
#Chemsky
#teammassspec

@davidsroberts.bsky.social, Andrew and I are our way to #ASMS2025 @asms.org 🥳

See you there?

#massspec #teammassspec

Antibody–Drug Conjugate Stability Probed by Variable-Temperature Electrospray Ionization Mass Spectrometry Antibody–drug conjugates (ADCs) are effective anticancer biotherapeutics, often referred to as “magic bullets” due to their high specificity and cytotoxicity. This unique drug class consists of cytoto...

Antibody–Drug Conjugate Stability Probed by Variable-Temperature Electrospray Ionization Mass Spectrometry #JASMS pubs.acs.org/doi/10.1021/...

We heat up the ADC at the inlet of the mass spectrometer, separate the isoforms within the instrument and analyze each isoform in one run. This is one step away from the commonly used methods that probe only the bulk stability and gives direct insights into each specific drug-load species.

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ADCs are heterogeneous drug products. They are antibodies linked with varying amounts of drugs. Their stabilities are often assessed at the bulk level, completely ignoring the fact that the individual drug linked species have different properties! That’s where vT-ESI-MS can help.

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Antibody–Drug Conjugate Stability Probed by Variable-Temperature Electrospray Ionization Mass Spectrometry Antibody–drug conjugates (ADCs) are effective anticancer biotherapeutics, often referred to as “magic bullets” due to their high specificity and cytotoxicity. This unique drug class consists of cytoto...

Ever wondered how stable your ADCs are and how their stability is influenced by their drug-load?

Variable-temperature electrospray ionization can help with that!

Jan Fiala’s and my postdoc work in the lab of @hecklab.bsky.social was just published! 🥳🥳🥳

pubs.acs.org/doi/10.1021/...

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Some sections have been claimed already and I can only include a limited number of authors.

Deadline for the submission is July 1st, so we have to move fast.

Please feel free to share!

#TeamMassSpec #MassSpectrometry #Proteomics #MembraneProteins

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GitHub - dschust-r/review_ms_mem_prot: Community review on "Advances in Mass Spectrometry for Membrane Protein Pharmacology" Community review on "Advances in Mass Spectrometry for Membrane Protein Pharmacology" - dschust-r/review_ms_mem_prot

We will be writing the manuscript on GitHub, using Manubot. Please check out the repository for more information: github.com/dschust-r/re...

Feel free to DM me or post an Issue, if you’d like to contribute. Please tell me what section you would like to contribute to.

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Call for membrane protein mass spectrometry scientists! 🥼

I have the opportunity to write a short review on “Advances in Mass Spectrometry for Membrane Protein Pharmacology“, and I am looking for fellow membrane protein mass spec enthusiasts to contribute.

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Please join us for proteoform Thurs this Thurs. Our former student, David Roberts will be presenting. David is a very talented young scientist and a great speaker. Please register using the link 👇 please help share @proteoforms.bsky.social @joelooucla.bsky.social ❤️

Great presentation on #FragPipe and its capabilities. Definitely learned a lot!
Thank you @nesvilab.bsky.social for virtually stopping by to give a talk during our #proteomics users group meeting here @stanford.edu and for answering all our questions 😊

#massspec
#teammassspec
#StanfordProteomics

I have a timsTOF HT right now that I am very happy with! The Ascend is on my desk, the timsTOF in the lab 😊

You’re probably right 😂

That one is nice too! I wonder if they will have any new sets at ASMS this year 👀

Wow, the set DID come with other options, I completely missed that. Just thought they had - for some weird reason - included multiples of the same label.

That’s a good point! I just checked and mine is the MultiOmics edition. It came with some replacement labels (total of 3 labels), need to check them when I am at home. Will update you when I get home and am able to check 😊

Is is an Ascend 😊 Never saw a Lumos set but I imagine they would be almost impossible to distinguish

Do you have this one? It‘s not really an issue but just wondering. Looks much better with the proper source build 😊

I was missing 2 parts at the top, or I thought I was - do you also have a little gap at the top between the gray and black panels? I had used the parts from the source to make that edge even at the top but that looked bad. “Fixed“ the source after taking the picture because it started to bother me 😅