Diffusive spreading across dynamic mitochondrial network architectures | PNAS In eukaryotic cells, mitochondria form networks that range from highly fused interconnected structures to fragmented populations of individual orga...

Excited to share a new collaborative paper with Lena Koslover's team, fueled by @chanzuckerberg.bsky.social Metabolism Across Scales Program 🧪 1/
www.pnas.org/doi/10.1073/...

Edward C. T. Waters from @kings-bmeis.bsky.social et al. conducted this recent study where sarcolemmal and mitochondrial #membrane potentials were measured ex vivo and in vivo in the #heart by #pharmacokinetic modelling of [99mTc]sestamibi 🫀 🔎

📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

MitoAtlas: a Domain-Resolved Spatial Map of the HumanMitochondrial Proteome www.biorxiv.org/content/10.64898/2026.04...

PLIN5 phosphorylation orchestrates mitochondria lipid-droplet coupling to control hepatic lipid flux and steatosis - Nature Metabolism Using single-cell tissue imaging and spatial proteomics to study mitochondria–lipid droplet coupling in hepatocytes, PLIN5 phosphorylation is identified as a mediator of lipid flux and nutrient stress...

1/9
🚨 New paper out in Nature Metabolism! Chapter 2 of our mitochondria zonation story (following our 2024 Nature Communications work). We asked how zonated liver mitochondria adapt when lipid flux surges. 🧵👇
www.nature.com/articles/s42...

Mitochondrial lactate venting limits oxidative stress The main function of mitochondria is to generate ATP by oxidizing pyruvate to CO2. Rauseo et al. show that matrix pyruvate is also converted to lactate, which is released to the cytosol via the MPC to...

Mitochondrial lactate venting limits oxidative stress

www.cell.com/cell-metabol...

We are hiring POSTDOC now!🚨please repost! Fully-funded 5-year position 👩🏻‍🔬👨‍🔬🧬Looking forward to your application!✉️

Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism mTORC1 does not always hold the key to unlocking the mechanical load-induced growth of skeletal muscle.

It's been a long time since I sat down and enjoyed reading a paper cover-to-cover as much as this. Some cracking work and experiments.

www.science.org/doi/10.1126/...

Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy @cellcellpress.bsky.social @aleprigio.bsky.social
www.cell.com/cell/fulltex...

Another preprint is out from the Neal Lab! 🎉

Excited to share the first systematic side-by-side comparison of ERAD Derlin paralogs, revealing distinct cellular functions for Derlin-1, Derlin-2, and Derlin-3.
www.biorxiv.org/content/10.6...

Impaired stem cell migration and divisions in Duchenne muscular dystrophy revealed by live imaging - Nature Communications Using live-imaging in vivo and ex vivo, Sarde et al. show that dystrophic muscle stem cells have precocious differentiation through symmetric divisions and impaired migration, with differential impact...

Bravo Liza, Brendan and colleagues for the elegant work on multiple live imaging strategies to untangle mechanisms of muscular dystrophy! www.nature.com/articles/s41...

Two funded PhD positions investigating the evolution of sarcomeres @ibdm.bsky.social in @biancah0406.bsky.social and our lab, together with @cnidevo.bsky.social - Interested to explore how similar or different Jellyfish sarcomeres are to Drosophila or human ones?
www.ibdm.univ-amu.fr/ibdm_job/2-a...

Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037) | The Norwegian School of Sport Sciences Job title: Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037), Employer: The Norwegian School of Sport Sciences , Deadline: Wednesday, March 11, 2026

Now recruiting an experienced Post‑Doc in Skeletal Muscle Molecular Physiology @nih-sport-sciences.bsky.social Oslo, Norway

Join our multi‑omics EMMA project on mitochondrial epigenetic memory in human muscle aging

4‑year position

Start May

Apply at Jobbnorge: www.jobbnorge.no/en/available...

Macroscopic to Ultrastructural Analyses Identify the Loss of Myofibrils as the Primary Mediator of Muscle Fiber Atrophy in Aging and Disuse www.biorxiv.org/content/10.64898/2026.02...

Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!

We are ready to scale up glycogen analysis using electron microscopy.
By applying a new AI-based image analysis pipeline, workload for 50 samples was reduced from ~600 hours to ~20 hours. This moves us beyond small-scale TEM studies.
Details below 👇

An overhead view of a dissected rat muscle resting on grid paper.

The same view of the muscle as Image 1, but the muscle is translucent and grid lines are visible through it.

A fluorescence micrograph of the rat tibialis anterior muscle, stained to differentiate the long nerve fibers from the dot-like neuromuscular junctions.

A higher magnification of Image 3.

The innervation of the tibialis anterior muscle in a rat has never been so clear! Processed with SmartBatch+ by the UIC/Structural Circuits Core, for @greisinglab.bsky.social in the UMN School of Kinesiology. Red = nerves, yellow = neuromuscular junctions. #3DThursday @lifecanvastech.bsky.social

We are hiring!
Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches.
Please share!

More about us: martinottlab.com

Apply here:
web103.reachmee.com/ext/I005/103...

Breaking Fundamental Biological Law: Research by Takashi Akera Investigates Selfish DNA - Vilcek Foundation Winner of the Vilcek Prize for Creative Promise, Akera’s novel research findings have huge implications for infertility and chromosomal disorders.

vilcek.org/news/breakin...

New #NatureComms paper: CHAMP1 is an essential regulator for human myoblast fusion and muscle development. #Myoblue tinyurl.com/2wyu39fr

High carotid blood flow velocity and pulsatility are negatively associated with hippocampal mitochondrial respiratory states.

High carotid blood flow velocity and pulsatility correlate with lower hippocampal mito oxygen consumption, while both low and high flow increase mito fusion protein expression compared to control. Thanks to Drs. J. Carson Smith and Gabriel Pena for the collaboration! ahajrnls.org/3YmmdMj

Mitochondrial Reticulum in Skeletal Muscles: Proven and Hypothetical Functions - Biochemistry (Moscow) Abstract The mitochondrial reticulum of skeletal muscles has been characterized in the 1970-80s. It has been suggested and then proven its role is delivering energy in a form of transmembrane potentia...

Mitochondrial Reticulum in Skeletal Muscles: Proven and Hypothetical Functions
link.springer.com/article/10.1...

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

📄 New preprint

Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans.

👇 Link in first comment

#Physiology #Diabetes #Mitochondria #Metabolism

Self-renewal of neuronal mitochondria through asymmetric division Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia - Nature Cardiovascular Research Giles et al. developed a method for noninvasive absorbance measurement of mitochondrial hemes to monitor the mitochondrial membrane potential in the perfused heart. They then applied this approach to ...

Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy.

doi.org/10.1038/s441...

Excited to share our new paper on high-throughput #optogenetic #exercise assays for tissue engineered skeletal muscle! We leverage a multi-well stimulation apparatus to study how exercise regimen of various durations + frequencies impact muscle gene expression:
doi.org/10.1002/btm2...

#myoblue

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle - Skeletal Muscle Non-peripheral (displaced) myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to th...

Nice work and congrats @kevinmurachphd.bsky.social & colleagues for their new #SkeletalMuscle paper: Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle. #Myoblue tinyurl.com/3vhxwku4

Structure and mechanism of the mitochondrial calcium transporter NCLX - Nature Cryogenic electron microscopy structures and functional analyses reveal that NCLX functions as a H+/Ca2+ rather than a Na+/Ca2+ exchanger, and uncover its transport mechanism with implications for the...

NCLX is a mitochondrial proton/calcium exchanger, not a sodium/calcium exchanger as previously thought
www.nature.com/articles/s41...

MICU2 controls mitochondrial calcium signaling and migration in neurons during development Berezhnaya et al. showed that MICU2 is present in the brain during development but is replaced during maturation by MICU3. MICU2 loss during development results in neuronal overmigration in the cortex...

Happy to have contributed to this beautiful work led by @elenaberezhnaya.bsky.social and Dr. Gyorgy Hajnoczky, and thrilled to see it finally out! 👏🏽👏🏽👏🏽

MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...

Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue