Clearly, We've Lost Control.

Enteroendocrine cells (green) in pluripotent stem cell-derived human intestinal organoids

Our work characterizing enteroendocrine cell (EEC) differentiation trajectories and the underlying GRNs in pluripotent stem cell-derived human intestinal organoids has been published today in @biologyopen.bsky.social. Thanks to all.
doi.org/10.1242/bio....
#organoids; #EEC; #Enteroendocrine cells

Symposium to Celebrate the career of Francois Guillemot at @ the Francis Crick Institute in London. Thanks for all Francois. Was great to catch up with all the friends.

Only one week left! We’ve already received many exciting applications and are expecting more. Maybe yours!

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- Most EEC cells are specified during development through similar differentiation trajectories as observed in the adult intestine.
- Crypt-villus organization is not essential for EEC formation.
- Novel GRNs are identified governing human EEC differentiation in human intestinal organoids.

Unraveling Enteroendocrine Cell lineage dynamics and associated gene regulatory networks during intestinal development Enteroendocrine cells (EECs) are rare intestinal epithelial cells producing multiple hormones that regulate essential aspects of digestion and energy. EEC subtypes, their hormone repertoire and differ...

1/2. I am pleased to announce that the preprint of our latest study characterizing mouse and human EEC development is now on BioRxiv. A great collaboration with the @molinalab.bsky.social and Maxime Mahe (not on bluesky)
www.biorxiv.org/cgi/content/...

We are hiring PhD students! Interested in #ComputationalBiology and #MachineLearning? Join our lab at the @IGBMC! #PhDposition euraxess.ec.europa.eu/site/search

The unintended (?) consequence of the tariffs is that the reduced consumption it'll drive will probably significantly reduce greenhouse gas emissions

Important diabetes news. Unfortunately, while VX264 (Vertex's encapsulated stem cell derived islet product) has been safe in patients, the company has discontinued the trial due to insufficient function of the cells. investors.vrtx.com/news-release...

@novonordiskcom.bsky.social licenses a P2 ready triple agonist #obesity #diabetrs #MASH www.novonordisk.com/content/nnco...

NEW: Elon Musk’s X has suspended accounts of Turkish opposition groups, suppressing footage of anti-government protests.

So, best we share all the footage we can here!

This was last night’s massive demo against Erdogan’s government, which follows the arrest of his rival Ekrem İmamoğlu.

🇹🇷 #Turkey

Not only academic conferences, may be also simply tourism in the US…

I guess this means I’m not going to the US for the next four years - at least.

Symposium on ‘Enhancer Sequences’ at beautiful @collegedefrance.bsky.social in Paris, by April 11th. Open and free, no registration. Come to relax listening to facts #TherapeuticEffects #VillageGauloix Final programme below. Tell your friends! 🙏🤘

Full support from France. I cannot believe what is happening. Do not give up Resist !

Yesterday's article in Le Monde regarding #StandUpforScience and the events planned tomorrow in France.
Here is the link to the English version, though partially paywalled.

www.lemonde.fr/en/science/a...

@standupforscience.bsky.social
@standupforscifr.bsky.social

CALL FOR TWO GROUP LEADER POSITIONS IGBMC 2025 The Institute of Genetics, Molecular and Cellular Biology (IGBMC), a leading European research institute near Strasbourg, France, is seeking two outstanding group leaders to establish independent research teams in Development & Stem Cells & Integrated Structural Biology.

CALL FOR TWO GROUP LEADER POSITIONS IGBMC 2025 The Institute of Genetics, Molecular and Cellular Biology (IGBMC), a leading European research institute near Strasbourg, France, is seeking two outstanding group leaders to establish independent research teams in Development & Stem Cells & Integrated Structural Biology.

We're hiring! The Development & Stem Cells department at @igbmc.bsky.social, Strasbourg 🇫🇷 is recruiting a group leader working in cell & developmental biology. Our Integrated Structural Biology department also has an open call. More details below! + contact me for informal enquiries #sciencejobs

But: this isn’t a meeting that went badly for Zelenskyy. It’s a meeting that went horrifically for Americans: the Trump admin is isolated in its support for Russia here, as we saw just earlier this week when it took its place among Russia’s other client states to vote against Ukrainian sovereignty

With Trump, Alliances Come With Strings Attached President Trump has little use for America’s traditional alliances, and tends to evaluate U.S. relationships according to whether countries are contributing economically to the United States.

After World War I, Germany had to fork over billions to cover damages. After World War II, Japan was forced to pay reparations. But with Ukraine, Trump is flipping history upside down by demanding that the invaded, not the invader, pay up. www.nytimes.com/2025/02/27/u...

Our job posting for 1 or more PDF positions in Vancouver Canada is now live here: tinyurl.com/4mrjw3m2

Please share/repost and apply soon!

Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'

Lots of interesting new TE (& genes) biology

Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/

Donald Trump signs order shifting US back towards plastic straws The president has long been a critic of paper straws, which he says don't work and dissolve too easily.

I am devastated by so many irresponsable decisions www.bbc.com/news/article...

Long-term outcomes and challenges of islet transplantation in type 1 diabetes β-cell replacement is a validated therapy for severe forms of type 1 diabetes.1 In patients with frequent severe hypoglycaemic events, allogeneic pancreatic islet transplantation results in better gly...

Mikael Chetboun & François Pattou comment on:
Long-term outcomes and challenges of #islet #transplantation in type 1 #diabetes thelancet.com/journals/lan... #T1D

I have TH LP in my basement...

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

I do hope that President Trump and Mr Musk realize that US biomedical research is still one of our strengths and only possible because of NIH funding

While it may be true, as claimed by Mr. Bannon, that in the IT industry H1b visas have been abused to bring in cheap labor, in biomedical research progress can only be made by recruitment of foreign fellows. There simply are not a sufficient pool of US born Ph.D.s left who want to work in academia

Friday Lectures – Giacomo Cavalli

Join us on Friday, 7th February at 3pm for a talk by Giacomo Cavalli, expert in Polycomb regulation and 3D genome architecture.
He’ll explore how these mechanisms affect epigenetic inheritance and cancer development.
Don’t miss it!
#Epigenetics #Genomics #Cancer