Congrats Thomas!!

Our lab is hiring!

As our fierce technician is moving on to graduate school (GO ANNA!), we’re looking for a new tech to join our team studying bacteria-phage interactions.

Ideal for recent grads interested in molecular biology and microbiology - please reach out with a CV to aviramn@mskcc.org.

Join IGH as Group Leader - IGH The Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more...

We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...

#JobOffer

💼 Professeur en stabilité du génome
📍Institut Jacques Monod
📆 1e septembre 2026

Les candidatures sont ouvertes jusqu'au 3 avril 2026 16h🔗 u-paris.fr/recrutement-...

A thread on our latest paper from the Whitehouse lab

CAD-C reveals centromere pairing and near-perfect alignment of sister chromatids Three-dimensional (3D) genome organization plays a central role in gene regulation, chromatin folding, and genome stability. Although chromosome-conformation capture (3C)-derived methods have revoluti...

Hi all!
We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids.

www.biorxiv.org/content/10.6...

#3DGenome #chromatin #Cohesin #centromere

Hi all !
Happy to share that I will open a lab at the LBMC at ENS-Lyon thanks to the #ATIP-Avenir funding.
We will investigate the role the 3D chromatin organization in Replication and Repair.

www.ens-lyon.fr/LBMC/equipes...


Job offers out soon!
#NewPI #3DGenome #chromatin #replication

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

We are hiring!
We are looking for a motivated and enthusiastic postdoc to study mammalian DSB repair using innovative genomic approaches.
Our lab is at the Curie Institute in Paris and offers vibrant scientific environnement and cutting edge platforms.
Please repost or apply here:
lnkd.in/eJ9q3QrR

Our paper is now out in Molecular Cell!

Check the thread in this former post:

www.cell.com/molecular-ce...

Hi everyone!

The latest method from the Whitehouse lab: PCP


PCP uses a novel proximity barcoding strategy to simultaneously map 3D genome organization at various resolutions at the single molecule level:

Out soon, check the updated BioRxiv – little thread:

1/11
www.biorxiv.org/content/10.1...

Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones - Genome Biology Background The identification of sites of DNA replication initiation in mammalian cells has been challenging. Here, we present unbiased detection of replication initiation events in human cells using ...

New paper! Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones

genomebiology.biomedcentral.com/articles/10....

Identifying human DNA replication initiation sites on single molecules by @nanoporetech.com 1/7

Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated

R-loops and Genetic Instability: a Chicken and Egg Problem Investigating the relationships between R-loops and genetic instability led to the discovery that some DNA:RNA hybrids actually arise as a consequence of DNA lesions.

🐣 What comes first — R-loops or genome instability?

There’s now a Behind the Paper to go with our recent study on the interplay between R-loops and DNA damage — with some context, backstory, and the chicken-and-egg question at its core.

Check it out 👉 go.nature.com/4ldXbJm

👏🏼🍾

R-loops and Genetic Instability: a Chicken and Egg Problem Investigating the relationships between R-loops and genetic instability led to the discovery that some DNA:RNA hybrids actually arise as a consequence of DNA lesions.

🥚🔄🐓 - Another narrative of our last paper: communities.springernature.com/posts/r-loop...

Nuclear and genome dynamics underlying DNA double-strand break repair Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...

How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @karimmekhail.bsky.social, @chiololab.bsky.social, and @lablegube.bsky.social. @natrevmcb.bsky.social Link to article: rdcu.be/edViW

Much grateful to @agencerecherche.bsky.social , @fondationarc.bsky.social and Ligue Nationale contre le Cancer for funding this project ! (7/8)

Congratulations to first author @raphaelmngn.bsky.social and many thanks to all our great collaborators 🧑‍🎓 - Rodney Rothstein @columbiamed.bsky.social, Sergio de Almeida @gimmfoundation.bsky.social, Peter Stirling @BCCancer and Pierre-Henri Gaillard @crcm.bsky.social (6/8)

Such « post-lesion » hybrids can be detected in yeast and human cells, yet they do not detectably impact genome stability, as opposed to « pre-lesion » hybrids - a revisited classification? (5/8)

For example, focusing on Okazaki fragments (OF) processing, we found that the accumulation of unprocessed flaps or unligated OF termini is the source of hybrid formation 🧬 (4/8)

We identified several situations where DNA:RNA hybrids are associated with genetic instability – strikingly, in most cases, DNA lesions appear to precede hybrid formation 🔃 (3/8)

🎉 Exciting News! 🎉

I’m super excited to share that my PhD work has just been published in Nature Communications! ✨

If you're curious about the discoveries we made, feel free to check out the thread below 😉.

Thanks to everyone who has been part of this journey! 🚀🧬

Full article : rdcu.be/ec1ET

In this study, we systematically explored the relationships between DNA:RNA hybrid formation and genetic instability, through a suite of genetic screens in yeast 🧬 (2/8)

Pleased to launch the Palancade lab Bluesky account with our new paper 📝, now out at @naturecomms.bsky.social (1/8)