New RCTs Advance #Incremental #Dialysis With Clinically-Guided HD and HDF-Based Prescriptions

https://doi.org/10.1016/j.ekir.2025.10.002

Original Article: https://doi.org/10.1016/j.ekir.2025.09.048
https://doi.org/10.1016/j.ekir.2025.08.043

#KIRCommentary

Medical breakthroughs in 2025 ... and a happy new year.

New post!

There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost.

Medical breakthroughs in 2025. Plus a serious note at the end.
www.scientificdiscovery.dev/p/medical-br...

Really interesting ; this study emphasises the influence of genetic variants to explain the great inter-individual variability of ultrafiltration in Peritoneal Dialysis patients even at PD onset together with the emerging role of peritoneal adipocytes and prostaglandins in peritoneal physiology 👏👏👏

Genetic Variation and Ultrafiltration with Peritoneal... : Journal of the American Society of Nephrology tration and explored one mechanistic pathway identified by genetic studies. Methods: We generated estimates of heritability and undertook genome-wide and gene-wise studies, adjusted for peritoneal ...

journals.lww.com/jasn/abstrac... Great work led by @rajmehrotra.bsky.social substantially improving our understanding of UF in PD

Will Xylocore® be the magic ELIXIR for peritoneal dialysis?

@ispd.org @pdi-journal.bsky.social @drnikhilshah.bsky.social @pd-perls.bsky.social @mlambie.bsky.social

Editorial: journals.sagepub.com/eprint/ENYAN...

Original article: journals.sagepub.com/doi/10.1177/...

Upcoming highlights in Advanced Kidney Care...

✅ AKC Symposium 2025
27 February, London
bit.ly/3ZTMXFt

✅ AKC Summit 2025
25 March, Birmingham
bit.ly/49GOl1v

✅ Transform AKC Programme
www.ukkidney.org/about-us/new...

💥Conakry PD Workshop

Insert PD catheter to manage AKI complications is crucial where indications are not lacking. Training to save (young) lives is essential

@sosendt.bsky.social @er-goffin.bsky.social @ispd1.bsky.social @theisn.org @sfndt.bsky.social

New treatment recommended for anaemia in adults on dialysis The National Institute for Health and Care Excellence have recommended a new treatment called Vadadustat as an option for treating anaemia caused by chronic kidney disease in adults on dialysis.

The National Institute for Health and Care Excellence has recommended a new treatment called Vadadustat as an option for treating anaemia caused by chronic kidney disease in adults on dialysis. You can find out more about this here: kidneycareuk.org/news-from-ki...

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia - Nature A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in obstetric d...

Wow just wow. I did not have on my bingo card an mRNA therapeutic for treating pre eclampsia. A VEGF tropic mRNA resolved maternal hypertension until pregnancy in a mouse model of the condition. Really fascinating science.
🧪
www.nature.com/articles/s41...

1/5 The #SWEETSTONE results were presented at the Swiss Society of Nephrology meeting:

Impact of #empagliflozin on urinary supersaturations in kidney stone formers.
Randomised, double-blind, placebo-controlled, cross-over trial.

#nephsky #nephrolithiasis #flozinator

I guess this answers the question : pubmed.ncbi.nlm.nih.gov/27890698/

Sharing the free access link here (for 50 days only) authors.elsevier.com/a/1k9u77tNuc...

1/
Hello, #NephSky!
Excited to share a 🆕 #Skeetorial on Automated Peritoneal Dialysis (APD) as a modality for Urgent Start Dialysis!
Brought to you by the fantastic team at @kireports.bsky.social Let's dive in! #skeetorial

We just added to www.ispd.org/guidelines the German translation for our ISPD 2022 Peritonitis Guidelines.

We thank Dr V. Schwenger for making these important guidelines available beyond language barriers.

Wanna help us translate ISPD guidelines? Please DM us for more info.

@TheLancet session at #AHA24 starting now! #obesity
🫀Malnutrition was a problem but now obesity is taking over worldwide with few exceptions
🫀Severe obesity has also ⤴️
🫀BMI doesn’t reflect obesity as well as waist-to-height ratio
🫀⤴️ diabetes follows obesity

Whilst assisted PD is more expensive, using nursing assistants, as in the UK, avoids competition with HD nurses and minimises the extra expenditure. Also often better for frail, elderly patients (e.g. no post HD fatigue).

Inebilizumab for Treatment of IgG4-Related Disease | NEJM IgG4-related disease is a multiorgan, relapsing, fibroinflammatory, immune-mediated disorder with no approved therapy. Inebilizumab targets and depletes CD19+ B cells and may be effective for treat...

We've already seen remarkable results for lupus and other autoimmune diseases with CD19 B cell depletion therapy. Now add IgG4 related disease (which has no treatment) in a new randomized trial
nejm.org/doi/full/10....

Tirzepatide for Obesity Treatment and Diabetes Prevention | NEJM Obesity is chronic disease and causal precursor to myriad other conditions, including type 2 diabetes. In an earlier analysis of the SURMOUNT-1 trial, tirzepatide was shown to provide substantial a...

#Tirzepatide for Obesity Treatment & Diabetes Prevention
SURMOUNT-1 Trial

✅ Reduced progression to T2DM by 93%
#CardioSky #EndoSky #MedSky #NEJM
www.nejm.org/doi/full/10....

The SONG-PD group rather than PDOPPS, but thanks for highlighting. ISPD guidance on HD transfers is on the way...