Can a drug combo control diabetes? Study finds empagliflozin cuts HbA1c in T2DM. #Type2Diabetes #Empagliflozin
www.rimpacts.com/rd/p?c=10094... 📄DOI: doi.org/10.1038/s415...
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Hashtag
#empagliflozin
Advertisement · 728 × 90
#Empagliflozin and #Ultrafiltration Volume in Patients Undergoing #PeritonealDialysis
#VisualAbstract by Elba Medina
www.kireports.org/article/S2468-0249(25)00...
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Also read the Linked Comment;
#Empagliflozin in chronic #kidney disease: evidence for early, inclusive, and confident use www.thelancet.com/journals/lan...
#CKD #T2D
#FREE to read with registration (also FREE)
#MedSky #endoSky #RenalSky
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#MedNews - SGLT2 inhibitor #empagliflozin significantly reduces the risk for acute and chronic kidney injury, regardless of the acute dip in eGFR soon after initiation and irrespective of the reason for treatment.
Full story 👉 buff.ly/YdMh728
#KidneyInjury #MedSky
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Linked Comment:
#Empagliflozin in chronic #kidney disease: evidence for early, inclusive, and confident use www.thelancet.com/journals/lan...
#SGLT2 inhibitor #CKD
#FREE to read with registration (also FREE)
#MedSky #EndoSky #RenalSky
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Carmine Zoccali & Francesca Mallamaci comment on:
#Empagliflozin in chronic #kidney disease: evidence for early, inclusive, and confident use thelancet.com/journals/lan...
#SGLT2 inhibitor #CKD
#FREE to read with registration (also FREE)
#MedSky #EndoSky #RenalSky
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New—Effects of #empagliflozin on conventional and exploratory acute and chronic #kidney outcomes: an individual participant-level meta-analysis thelancet.com/journals/lan...
#SGLT2 inhibitor #CKD
#OpenAccess
#MedSky #EndoSky #RenalSky
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☆ Pleased to share my paper in the European Journal of Pharmacology:
Empagliflozin reverses liver fibrosis & portal hypertension via Gal-1/NRP-1/TGF-β and VEGFR2 pathways, suggesting a novel antifibrotic approach.
Link: www.sciencedirect.com/science/arti...
#Pharmacology #Liver #Empagliflozin
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SGLT-2 inhibitors lower #death, #HeartAttacks, and #HeartFailure hospitalizations in type 2 #diabetes, with no effect on #stroke risk.
Key drugs: #Empagliflozin, #Canagliflozin, #Dapagliflozin.
#SGLT2 #HeartHealth #MetaAnalysis link.springer.com/article/10.1...
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Ja, det finns flera alternativ till Jardiance vid typ 2-diabetes. #dapagliflozin #empagliflozin #Forxiga #Jardiance #Metformin #Ozempic
bit.ly/4lsBViz
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#MedNews - In patients with #CKD and type 2 diabetes, #finerenone plus #empagliflozin combination therapy outperforms either monotherapy for UACR reduction.
Full story 👉 buff.ly/B7bvKuT
#Diabetes #T2D
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Type 2 #diabetes patients taking #semaglutide, often sold as #Ozempic or #Wegovy, have a slightly lower risk of #stroke compared to patients taking another diabetes drug - #empagliflozin
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✔️ Check out our interview with Rajiv Agarwal, who presented at #ERA25 on the efficacy of pairing #finerenone and #empagliflozin to lower UACR. #nephsky #nephrology #kidneydisease #ckd #diabetes www.docwirenews.com/post/combo-t...
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In the CONFIDENCE trial, combo therapy with #finerenone + #empagliflozin led to a >50% reduction in albuminuria over 180 days in patients with #CKD & #T2D — significantly greater than either drug alone. Safe, effective, synergistic.
👉 www.nejm.org/doi/full/10....
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#PublicationAlert Congrats to the newly minted Dr. Mourad et al on their paper on #singlecell transcriptomic of #SGLT2 expression. This comprehensive analysis shows minimal expression in ♥️ cells supporting an indirect/off-target role 4 #Empagliflozin impressive #HeartFailure benefits.
rdcu.be/ecUYs
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Pilot Study of Sodium-Glucose Cotransporter 2 Inhibitor #Empagliflozin Shows #Reduced Intrarenal #Complement Activation in Patients With #Diabetes and #CKD
doi.org/10.1016/j.ek...
#KIRResearchLetter #SGLT2inhibitor
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Empagliflozin in nondiabetic individuals with calcium and uric acid kidney stones: a randomized phase 2 trial 👩🔬🥼🧪👨🔬 #SGLT2I #empagliflozin #NephSky #CardioSky #Cardiovascular #KidneyDisease #cardiorenal @natureportfolio.bsky.social
www.nature.com/articles/s41...
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#SGLT2i #cardiAcfibrosis
suppresses
cardiac fibroblasts
#Empagliflozin #Dapagliflozin
#cardiosky
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#SGLT2i #SIRT6 #CardicFibrosis
#Empagliflozin #Dapagliflozin suppresses Angiotensin II- or TGFβ1-induced myofibroblastic differentiation of neonatal🐭cardiac fibroblasts
Partially via⏫Sirt6 expression (how?🧐) ⏬Nox4-ROS
#SciRep 2024
www.nature.com/articles/s41...
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Post-trial follow-up of EMPA-KIDNEY gave a more complete measurement of the total effects of 2 years of #empagliflozin in #CKD. #kidneywk #kidneydisease #nephrology #nephsky
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1/5 The #SWEETSTONE results were presented at the Swiss Society of Nephrology meeting:
Impact of #empagliflozin on urinary supersaturations in kidney stone formers.
Randomised, double-blind, placebo-controlled, cross-over trial.
#nephsky #nephrolithiasis #flozinator
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Image of three EMPA-Kidney hypothetical post-trial scenarios a) no carry-over effect of trial drug b) ongoing benefits after stopping trial drug c) harm from stopping trial drug oxford population health logo bottom right corner
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What'd I miss?
❗ 2022 EMPA-KIDNEY (pmid 39453837) showed #empagliflozin significantly reduced risk of progression of kidney dz & CV death in pts +/- DMT2 (mean f/u 2 yr, trial stopped early)
❓ But… THEN what happened?
🗓️ Post-trial follow-up for an additional 2️⃣ years 👇👇
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Did you miss last week’s #NephJC chat?
Too busy fretting over politics?
No worries, this #TenPostNephJC will get you all caught-up on Long-term Effects of #Empagliflozin in patients with #CKD
#NephSky #SkyNeph #MedSky
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SGLT2-Independent Vasoprotective effects of #Empagliflozin
Empagliflozin, but not another #SGLT2i Phlorizin, ⬇️#IntimalHyperplasia & #SmoothMuscleCell proliferation migration
Empagliflozin's effects are not phenocopied by siSGLT2, but⬇️ by AKT/STAT3
#JAHA 2024
www.ahajournals.org/doi/10.1161/...
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Arztbrieftext
Bei der Einnahme von GLP1Analoga (#Osempic, #Wegovy) und SGLT 2 Inhibitoren (#Dapagiflozin,
#Empagliflozin) empfehlen wir adäquate Maßnahmen zum Muskelerhalt um den Gewichtsverlust auf den Verlust von
Fettgewebe zu optimieren
(Sargeant et al. 2019)
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Research in the contex
MedSky🧪#IDsky #CardioSky🫀 @TheLancet In adults #hospitalised with #COVID19, #empagliflozin was not associated with reductions in 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death
www.thelancet.com/journals/lan...
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Encore presentation of the EMPA-KIDNEY trial data
Speakers:🗣️ @willkidney @AdeeraLevin @MasaomiNangaku
Moderators: 👥 @pecoitsfilho @aymwanghkuhk
#ThisIsISN #ISNeducation #Nephpearls #MedTwitter #Nephrology
#SGLT2inhibitors #EMPAKidney #empagliflozin
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Encore presentation of the EMPA-KIDNEY trial data
Speakers:🗣️ @willkidney @AdeeraLevin @MasaomiNangaku
Moderators: 👥 @pecoitsfilho @aymwanghkuhk
#ThisIsISN #ISNeducation #Nephpearls #MedTwitter #Nephrology
#SGLT2inhibitors #EMPAKidney #empagliflozin
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🦸This is going to be an EPIC discussion. Not biased, but more power🏋🏻♀️ To #SGLT2inhibitors #EMPAKIDNEY #gliflozin #empagliflozin
🥇U know it when a study is stopped early for positive outcomes! 🙌🏼
x.com/ISNkidneycare/…
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