Join us on Wednesday next week for two exciting talks on transcription regulation from @kasitc.bsky.social and @davidsuter.bsky.social!

You can register at: us06web.zoom.us/webinar/regi...

A graphic for the Marie Skłodowska-Curie Actions (MSCA), showing a historical portrait of Marie Skłodowska-Curie overlaid with an image of four young researchers walking down a hallway. The European Commission logo is in the top left. Text reads: "Marie Skłodowska-Curie Actions – €404.3 million to support postdoctoral researchers”

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

Been a great couple of days of fantastic talks at @embl.org in Heidelberg! Presented a poster, and have thoroughly enjoyed learning about all the great epigenetics research going on and making lots of new friends!! #EMBLChromatin

🚨New paper🚨Our new study with the lab of Phil Cole uncovers how SIRT6 dynamically adapts structurally and enzymatically to target diverse histone acylations (e.g., H3K27ac) within nucleosomes. @jonmarkert.bsky.social
doi.org/10.1016/j.jb... #Chromatin #SIRT6 #CryoEM

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

www.nature.com/articles/s41...

Assistant Professor (Research), Department of Anatomy and Cell Biology (C1-250306) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Come by my colleague!! Assistant professor position in molecular neurobiology at @mcgill.ca and the Lady Davis Institute! mcgill.wd3.myworkdayjobs.com/McGill_Caree...

Montreal is an amazing city and the Lady Davis is a great institute to work at!

Elucidating neuroepigenetic mechanisms to inform targeted therapeutics for brain disorders Therapeutics; Epigenetics; Neuroscience

Enjoyed writing this review on classic & emerging techniques being used to elucidate neuroepigenetic mechanisms using biochemistry, chemical and molecular biology in both in vitro/vivo models, with a focus on how these can drive therapeutic strategies in the near future.
www.cell.com/iscience/ful...

Transfer RNA acetylation regulates in vivo mammalian stress signaling An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.

Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.

www.science.org/doi/10.1126/...

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics.
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...

🥁We are just 3 days away from our next #FragileNucleosome seminar! We are delighted to host, 2 amazing ECR researchers @rachelhoffman.bsky.social & @jonmarkert.bsky.social this Wed!
PS1: Don't forget that US has switched to PDT
PS2: The recurring registration link:
us06web.zoom.us/webinar/regi...

I was that woman! I have frequently told the story of how Jeremy responded after my second NIH rejection. He said, “Whatever you do, don’t stop spending. If you run out of startup, we’ll find more money for you.” I didn’t need it in the end, but knowing he had my back was huge. Thank you!

At the #StandUpforScience protest in NYC—several hundred people turned out to Washington Square Park today to protest Trump’s cuts to public research

Maze lab at #standupforscience NYC! cut gels not funding!! 🧬

Maze lab representing!!

#StandUpForScience2025

List of Stand Up for Science events—official events in red, solidarity events in blue.

SO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING!

To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎

Yall better be both sharing the Stand up for Science posts /and/ figuring out how to get your butt to one of them!

@standupforscience.bsky.social

I will be at the Stand Up for Science NYC event on Friday! Calling all NYC and New York area based scientists to join!!

Mechanism for local attenuation of DNA replication at double-strand breaks @nature.com
www.nature.com/articles/s41...

Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇

Histone Lysine Crotonylation Regulates Long-Term Memory Storage Histone post-translational modifications (PTMs), particularly lysine acetylation (Kac), are critical epigenetic regulators of gene transcription underlying long-term memory consolidation. Beyond Kac, ...

www.biorxiv.org/content/10.1...

Computational design of serine hydrolases The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of ...

New research in Science represents a notable step forward in designing enzymes from scratch.

With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI

@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...

Oncohistone H3 E97K mutation facilitates CENP-A mislocalization and chromosomal instability in budding yeast Abstract. Mislocalization of overexpressed CENP-A (Cse4 in budding yeast) contributes to chromosomal instability (CIN) in yeasts, flies, and human cells. O

#Oncohistone #H3 #Histone #Chromatin #Cancer #BuddingYeast

academic.oup.com/nar/article/...

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC) The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...

Group Leader - Molecular Mechanisms of Environmental Adaptation We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...

Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org

We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇

embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

NIH cuts will cost Triangle universities millions. Now NC is suing Trump to block action. “We’re talking about massive layoffs across the Triangle if this (rule) holds,” former UNC-Chapel Hill Chancellor Holden Thorp said.

www.newsobserver.com/news/politic...
Good to see local papers picking up this massive disruption to work going on in our state