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RESEARCH PAPER: Bypass of blocking lesions by RNAPII reveals a novel stress induced by DNA damage
By Bañuelos et al. and Ramiro Verdun
➡️ https://ow.ly/ZfMy50YAOS1


#chromatin #histone #epigenetics #cellstress #chemotherapy

🧬 New work revisits an old favorite: hydrochloric acid-based #histone extraction! Simple, reliable, and compatible with SDS, 2D gels, and mass spec—making histone prep easier for downstream #analyses. #Epigenetics #HistoneResearch #MolecularBiology
https://ow.ly/vAp550Yh28O

A plant histone H3.3-specific amino acid safeguards the deposition of H3K36 methylation for proper development and stress responses Plant histone variant H3.3 uniquely carries T31 rather than the S31 found in animals. Li et al. demonstrate that T31 prevents plant-specific ATXR5/6-mediated H3K27me1 deposition, which would otherwise...

A plant #histone H3.3-specific #amino acid safeguards the deposition of H3K36 #methylation for proper #development and #stress responses

www.cell.com/developmenta...

#PlantScience #SciComm @cp-devcell.bsky.social @epigeneticspod.bsky.social @epigenometech.bsky.social @histone3.bsky.social

Fluorescent image from the website of the Giraldez Lab, Yale University

Alice is joining us from her postdoc at Yale U with Antonio Giraldez where she developed novel #cryoEM and #nanogold labelling techniques to study chromatin structure in cells at the scale of individual #histone proteins, building on her PhD at @bristoluni.bsky.social

www.giraldezlab.org

Sodium butyrate regulates the sulfur respiration of rhizosphere soil to produce hydrogen sulfide modulating histone acetylation dynamics to enhance drought tolerance in rice Sodium butyrate increases the numbers of sulfate-reducing bacteria in the rice rhizosphere, stimulating hydrogen sulfide (H2S) biosynthesis. H2S represses the histone deacetylase OsHDA710, thereby el...

Sodium butyrate regulates the sulfur respiration of #rhizosphere soil to produce #hydrogen sulfide modulating #histone acetylation dynamics to enhanc #drought tolerance in #rice

onlinelibrary.wiley.com/doi/10.1111/...

#PlantSci @jipb.bsky.social @rhizosphere.bsky.social @poolelaboxford.bsky.social

Person standing behind a lectern with a laptop, gesturing with one hand and holding a remote control in the other, next to a wall with the text 'Max-Planck-Institut für Immunbiologie und Epigenetik

Person standing behind a lectern with a laptop.

We had a super interesting seminar by Giacomo Cavalli (@cnrs.fr | @umontpellier.bsky.social), today. 🤩

… with exciting data and results by the Cavalli on epigenetic memory of past events that get mediated by Polycomb components & #histone #acetylation. Thanks to @iovino-lab.bsky.social for hosting!

CRM1 inhibits NPAT condensation and #histone locus body formation via a competitive occupation strategy. New study from Xiao Xia Cong, Shui Bo Xu, Wen Kai Zou, Xiu Kui Gao, Xiaohui Zou, Yi Ting Zhou, Li Ling Zheng (Zhejiang University) and colleagues: rupress.org/jcb/article/...

#Biocondensates

Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner.

#piRNA #histone #mRNA #maternal #RNAbiology #RNASky

www.biorxiv.org/content/10.6...

Cong et al. reveal that exportin CRM1 plays a “two birds with one stone” function by suppressing NPAT condensation and exporting NPAT to regulate #histone locus body formation. rupress.org/jcb/article/...

#Organelles #Biochemistry #Biocondensates

RESEARCH PAPER: Histone modification cross-talk and protein complex diversification confer plasticity to Polycomb repression
By Bonnet et al., and Jürg Müller
➡️ https://genesdev.cshlp.org/content/40/1-2/43.full

Max Planck Institute of Biochemistry
#polycomb #histone #chromatin #drosophila

Hangover regulates gene expression by limiting NSL-mediated H4K16 acetylation Abstract. The RNA-binding protein Hangover (Hang) is essential for several stress responses in Drosophila melanogaster. Here, we discover a novel function

🚨Paper Alert🚨
We found a novel transcription factor function of the zinc finger protein “Hangover” in the regulation of Drosophila gene expression🪰🧬:

doi.org/10.1093/nar/...

#chromatin #transcription #hangover #histone modification #NSL complex

A thread:

Have a look at the new issue:

link.springer.com/journal/4431...

The cover features work by Amanda Amodeao @aaamodeo.bsky.social and co-workers showing that local nuclear to cytoplasmic ratio regulates #histone H3.3 incorporation during zygotic #genome activation.

link.springer.com/article/10.1...

Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.

Yohsuke T. Fukai, Kyogo Kawaguchi, et al. reconstituted gene-scale #chromatin arrays with controlled #histone modification patterns in vitro and showed that heterogeneous #acetylation alone can drive pattern-dependent changes in chromatin architecture and dynamics.
doi.org/10.1126/scia...

Here you can see a crystal structure of human PARP15 in complex to a quinazolin-4-one inhibitor (PDB code: 9FEG)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #cancer #parp15 #inhibition #histone #xray

Interesting study showing how H3K36me2 modulation is critical for post-implantation DNAme re-establishment. #epigenetics #histone #EarlyDevelopment

RTF1 enhances CLK occupancy and #histone methylation at key #circadian clock pacemaker gene loci, say Xu Liu, Ya Huang, Yong Zhang and colleagues (Soochow University): rupress.org/jcb/article/...

#CellSignaling #Chromatin #epigenetics #Neuroscience #Genetics

Ines Anna Drinnenberg @institutcurie.bsky.social @sorbonne-universite.fr and co-workers @nordicembl.bsky.social show that #insects evolved a conserved monomeric #histone fold domain in the CENP-T #kinetochore protein family. #evolution

-> www.embopress.org/doi/full/10....

Brian Lam of yorkuniversity.bsky.social et al. observed that #endurance training increases a ubiquitylated form of #histone H3 in the skeletal muscle, supporting Notch1 upregulation in an MDM2-dependent manner 🏃 🧬

📜 🔗 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Histone H3.3 Phosphorylation Switch Controls Chromatin Dynamics

Phosphorylation of histone H3.3 at serine 31 (H3.3S31ph) turns nucleosomes into a dynamic state in macrophages, enabling rapid gene activation; study published Sep 12, 2025. getnews.me/histone-h3-3-phosphoryla... #histone #chromatin #immunology

Validate User

From #NAR journal | #Cancer #histone mutations impact protein binding and DNA repair with possible links to genomic instability | From my friend @davidlandsman.bsky.social & former colleague @panchenko-lab.bsky.social | #Bioinformatics #Genomics 🧬 🖥️ 🧪 🔓 🇨🇦
⬇️
academic.oup.com/nar/article/...

In Horticulture Research, using advanced techniques like ChIP-seq and transcriptomic analysis, the research team from Jianghan University has mapped the distribution of four histone modifications across the pea genome.
#Histone modifications #Pea
Details: doi.org/10.1093/hr/u...

🧬👩‍🔬Este evento reunió a más de 600 personas del ámbito de la investigación nacionales e internacionales relevantes en ámbitos como la bioquímica, la biología molecular o la biomedicina.

#science #conference #biology #ibfg #biotech #biologia #histone #ciencia

New work in #RESInsectMolecBio finds that #Histone #acetyltransferase p300/CBP regulates reproductive #diapause via the juvenile hormone pathway in the cabbage beetle, #Colaphellus bowringi
doi.org/10.1111/imb.70007

#JH #Photoperiods
@sassanasgari.bsky.social @gulianusslab.bsky.social @wiley.com

A research team from the South China Botanical Garden of the Chinese Academy of Sciences published a study on August 14, 2024, in Horticulture Research, identifying a novel epigenetic regulator of tomato fruit ripening.
#Histone deacetylase #HDACs
Detail: doi.org/10.1093/hr/u...

Last week there was a #GRS and #GRC meeting on #Histone and #DNA modifications in Tuscany, Italy. I learnt a lot and am very grateful for being able to share my early-stage postdoc research at the #GRS. Fantastic atmosphere and hope to engage with this dynamic community again in two years.

In the journal Horticulture Research on September 16, 2024, using ChIP-seq, RNA-seq, and metabolomic profiling, the team charted the distribution and regulatory functions of four histone modifications.
#Pea #Histone modification
Details: doi.org/10.1093/hr/u...

CRAMP1’s surprising grip on linker histones In this issue of Molecular Cell, Ingham et al. and Matthews et al. report CRAMP1 as a key regulator of linker histone transcription in human cells.

CRAMP1’s surprising grip on linker histones

#histone #stress #DNA 🧪

www.cell.com/molecular-ce...

A research team from the South China Botanical Garden and Guangdong AIB Polytechnic published a study, in Horticulture Research, revealing the regulatory function of histone deacetylase SlHDA7 in tomato fruit ripening.
#Histone deacetylases
Details: doi.org/10.1093/hr/u...

Nucleosomes--which are composed of histone proteins (purple) wrapped in strands of DNA (green)--appear to regulate gene activity via inherent biophysical properties. Image credit: Science Source/THOM LEACH

Here’s the secret to how #nucleosomes shape the #genome. In PNAS Journal Club: www.pnas.org/post/journal...

#histone #chromatin #GeneExpression #condense-seq #GeneActivity

The #histone variant H2A.Z is key to neurodevelopment—but how is it placed at the right #genes? This new study from @gildastef.bsky.social‬ shows how SRCAP ensures proper H2A.Z loading during neuronal differentiation
buff.ly/tk5PyQe
#Epigenetics #Neuroscience #ChromatinRemodeling