Our latest project, ADAPT-E will develop a new framework, to help #surgeons and #researchers design and safely conduct early evaluation studies of #surgical innovations, which includes planned changes to which #patients are invited to take part throughout a study.

www.bristol.ac.uk/population-h...

Many congrats to our student James Olivier on passing his MD and we wish him every success for the future and in all that lies ahead! #surgery #research

bmjopen.bmj.com/content/15/6...

We are exploring how early phase surgical studies are inclusive – see protocol – results to follow!
bmjopen.bmj.com/content/16/2...

Our Bristol Centre for Surgical Research ROSE study (ISRCTN51267295), testing a digital symptom reporting tool for patients discharged home after #surgery for #cancer, has passed its pilot phase & will continue to recruit until May 2027. Thanks to all those involved! @bristol-csr.bsky.social

Early fluid therapy trajectories in acute pancreatitis: a retrospective cohort study - World Journal of Emergency Surgery Background Individualized management of early fluid therapy in acute pancreatitis (AP) remains challenging. Traditional studies primarily focus on static fluid balance, overlooking the heterogeneity of dynamic trajectories. Methods Based on a single-center retrospective cohort, 3,142 AP patients admitted within 72 h of onset were included. Daily fluid therapy-to-body weight ratio (FWR) and CumFWR (trapezoidal AUC) were calculated. Latent Class Growth Modeling (LCGM) identified dynamic FWR trajectories within 72 h. Multivariate Cox regression analyzed the relationship between FWR and in-hospital mortality risk. Three-dimensional fitted surface plot analysis evaluated interactions between CumFWR and hematocrit. Results LCGM successfully identified five distinct dynamic fluid therapy trajectories within 72 h, showing significant clinical differences: Low Stable Group (LSG1, n = 229, 7.3%), Low-Moderate Sustained Group (LMSG2, n = 340, 10.8%), Moderate Stable Group (MSG3, n = 2073, 66.0%), Moderate-High Fluctuating Group (MHFG4, n = 231, 7.4%), and High Sustained Group (HSG5, n = 269, 8.6%). Multivariate Cox regression revealed significantly increased in-hospital mortality risk compared to MSG3 for both MHFG4 (adjusted HR = 2.08, 95%CI 1.15–3.78) and HSG5 (adjusted HR = 2.91, 95%CI 1.77–4.79). Furthermore, each 1 standard deviation increase in CumFWR was associated with a 47% increased mortality risk (HR = 1.47, 95%CI 1.26–1.72). Three-dimensional fitted surface plot demonstrated high mortality risk between high CumFWR and abnormal hematocrit (low/high HCT), particularly prominent in the HSG5 group (p < 0.001). Conclusion This study reveals five distinct dynamic trajectory patterns of early fluid therapy in AP. High-load sustained or fluctuating therapy significantly increases mortality risk. Dynamic monitoring of HCT (within a 35–44% safety window) and therapy trajectories offers a potential strategy to optimize fluid management.

New Insights on Fluid Management in Acute Pancreatitis

by Wan J, Xiong S (...) Xia L et 6 al. in World J Emerg Surg #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article:

Important research published from one of our #cancer #surgical #RCTs with embedded quality assurance methods using medical images and intra-operative videos.

www.nature.com/articles/s41...

Inclusive research cultures: Addressing ethnic inequality through collaboration - Bristol Biomedical Research Centre The University of the West of England (UWE) are excited to announce the launch of their first ‘Ethnic inequality conference’ on 4 November 2025 at UWE, Bristol. The aim of this conference is to create...

One of our students presented research looking at diversity + inclusion in studies evaluating innovative + developing surgical procedures at the Ethnic Inequality Conference at @chcr-uwe.bsky.social + was awarded a prize!

www.bristolbrc.nihr.ac.uk/events/inclu...

Landmark gastric bypass trial presented to policymakers at Evidence Week - Bristol Biomedical Research Centre The By-Band-Sleeve trial, which recently found gastric bypass is the most clinically and cost-effective form of interventional surgery for people living with severe obesity, has been presented to poli...

Earlier this month, Jane Blazeby, Barney Reeve and Anni King presented their gastric bypass surgery recommendations at @senseaboutsci.bsky.social Evidence Week.

The event enabled them to talk to key government decision makers.

@bristol-csr.bsky.social
www.bristolbrc.nihr.ac.uk/landmark-gas...

Disparities in minimally invasive surgery for elective inguinal hernia repair across Europe: secondary analysis of an international cohort study Minimally invasive surgery (MIS) utilization in elective inguinal hernia repair varies significantly across Europe. In this analysis of 8355 patients from

Our doctoral student @slawday.bsky.social was part of the writing group for HIPPO study, looking at minimally invasive #hernia #surgery rates across Europe which found significant disparities in access to #laparoscopic or #robotic inguinal hernia surgery
academic.oup.com/bjsopen/arti...

News on the latest Artificial Intelligence based research projects. Including our automated image analysis to facilitate the quality assurance measures into surgical RCTs.
#AI #research #surgery #trials
elizabethblackwellinstitute.blogs.bristol.ac.uk/2025/10/15/m...

Read about our latest findings on gastric bypass as the most clinically and cost effective weight loss surgery for the NHS
#surgery #obesity #research

www.bristol.ac.uk/policybristo...

We're in UK parliament today at #evidenceweek presenting to MPs, peers and parliamentary staff our research on weight-loss surgeries in the Jubilee room, Westminster.
@senseaboutsci.bsky.social

Find out more: senseaboutscience.org/evidence-wee...

The future of surgery: safe and transparent innovation | The Bulletin of the Royal College of Surgeons of England When innovation skips safeguards, the fallout is significant. Here’s how to protect patients, surgeons and the system.

The future of surgery: safe & transparent innovation – read more to see what is needed

publishing.rcseng.ac.uk/doi/full/10....

We’re at Westminster next week for #EvidenceWeek with @senseaboutsci.bsky.social, presenting our research evidence on the best surgery for #weightloss to MPs, peers and parliamentary staff, to help them scrutinise policies in this area. senseaboutscience.org/evidence-wee... #obesity #surgery #NHS

Next week we’re at #EvidenceWeek in Parliament with @senseaboutsci.bsky.social to present the results of the world’s largest surgical obesity trial. MPs, peers and parliamentary staff can book their quickfire policy briefing and find more information about the whole week with us here:

CSR members attended the @nihr.bsky.social
Team Science Camp last month to learn about and develop an interdisciplinary team to tackle challenges around decarbonising healthcare, social care + research.

Evidence is vital in effective decision-making. We’re presenting study findings on #surgery for weight loss in Parliament at #EvidenceWeek

We hope to see you there!
@kirithentwistle.bsky.social @liztwistmp.bsky.social @joshfg.bsky.social

Booking + info
senseaboutscience.org/evidence-wee...

Evidence is vital in effective decision-making. We’re presenting our latest findings on the worlds largest surgical weight loss trial in Parliament as part of #EvidenceWeek on the 4th November with
@senseaboutsci.bsky.social

senseaboutscience.org/evidence-wee...

Patient + Public Involvement + Engagement (PPI)E is key to ensuring our projects are patient-focused. Our new NIHR SPOC-TRC brings together Biomedical Research Centres focusing on surgery and peri-operative care. We are working to improve PPIE in early phase research

Looking to combine cutting-edge research with high-quality clinical training?

The NIHR Academic Clinical Fellowship in General Surgery at Bristol offers 25% protected research time, expert mentorship, and a route to doctoral funding.
💡 Apply now: www.oriel.nhs.uk/Web/Vacancy/...

Continuity of outcome assessment throughout the lifecycle of surgical research: mapping core outcome domains measured in early phase and late phase studies - BMC Surgery Background Consistent outcome assessment in surgical research, from early phase studies (during introduction and refinement of new procedures) to late phase studies (to establish comparative effectiveness) needs improvement to ensure efficient and safe surgical care. This study explored the potential continuity of outcome domain assessment throughout the evaluation lifecycle of surgical interventions. Methods Core outcome sets (COS) for late phase studies of surgical interventions were identified through COMET database searches. Core outcomes/outcome domains were extracted and mapped to core domains of a COS developed specifically for evaluating surgical innovation (COHESIVE COS). Outcomes/domains were categorised as “definite match” (clear similarity), “possible match” (potential similarity) and “no match” (no similarity) COHESIVE domain based on similarity in wording or meaning. Results A total of 54 COS studies were included, yielding 573 core outcomes/domains. Most late phase core outcomes/domains (N = 519, 91%) showed clear or possible similarity. All late phase COS studies recommended measurement of COHESIVE domains ‘Intended benefits’ and ‘Expected and unexpected disadvantages’. Some late phase outcomes/domains also showed similarity with early phase COHESIVE domains, including ‘Problems with the device working’, ‘Patients’ experience’ and ‘Operators’/surgeons’ experience’. A minority of late phase outcomes/domains showed no similarity with COHESIVE domains (n = 54, 9%). Conclusion High similarity between outcome domains recommended in early and late phase evaluations of surgical interventions demonstrates continuity of outcome domain assessment throughout the surgical innovation lifecycle is possible. Harmonising outcome measurement throughout the research pathway can streamline evaluation, enhancing access to beneficial treatment and improving early detection of harms.

Important work from our centre on continuity of outcome assessment throughout the lifecycle of surgical research: mapping core outcome domains measured in early phase and late phase studies.

link.springer.com/article/10.1...

🚀 Launch your academic career in surgery with the NIHR Academic Clinical Fellowship at the University of Bristol!
Join world-leading researchers at the Centre for Surgical Research and gain hands-on experience developing studies that change practice.
🔗 www.oriel.nhs.uk/Web/Vacancy/...

Many congrats to all the delegates for impressing the Dragon's and designing some inspiring RCTs at BOASTiC - and especially to the C-Scar team - Cameron Clarke, Shikha Kodliwadmath, Samar Mohamed Mousa and Riadh Salem - for winning first prize! #BOASTiC #research #surgicaltrials

Graphic with NIHR Applied Research Collaboration South London logo. Heading: “An Introduction to Implementation Science: Online module.” Text: “Implementation science is the study of methods to support the application of evidence and research findings in health and social care policy and practice. This six-week, CPD-accredited module has been created by a team of implementation science experts working at NIHR ARC South London and the University of East Anglia. It is suitable for anyone interested in improving health and social care services.” At the bottom: “Booking now open for course commencing Oct 2026.” On the right side is an illustration of a person with a backpack sitting at a desk, watching an online lecture on a computer screen with charts and a speaker.

Register now to join our Introduction to Implementation Science Online Module this October

arc-sl.nihr.ac.uk/imp-sci-module

@nihrarcs.bsky.social

Excellent three days in Bristol as part of the #BOASTiC (Bristol Oxford Aberdeen Surgical Trials Course). We've enjoyed the in-depth look at surgical trials with delegates designing their own studies by the end of the 3rd day! @marionkcampbell.bsky.social @situ-oxford.bsky.social

A graphic for NIHR Applied Research Collaboration South London. The background shows a blurred audience at an event, with a woman in the foreground facing the stage. Text on the image reads: "NIHR Applied Research Collaboration South London" "Active Involvement in Research 2025" "The Foundry: Tue 28 Oct, 9.30am–1.30pm" "Online: Tue 11 Nov, 5.30–6.30pm"

Join us - either in person or online - at our free events to help shape the future of applied health and care research in London 👇

arc-sl.nihr.ac.uk/events-train...

We are excited that our BOASTiC course is full and taking place later this month. A new course about early phase surgical studies is now in development.
www.bristol.ac.uk/population-h...

Research from the centre makes this months front cover of @bjsopen.bsky.social

academic.oup.com/bjsopen/issu...

#AI #surgery #research

Graphic from King's Improvement Science, featuring a quote and two headshots. The quote reads: “For healthcare professionals, being on a waiting list for elective surgeries and procedures may seem routine – but it has significant impact on the patient. This study was however able to identify possible ways of mitigating this distress, which formed the basis of the study key guidance and recommendations. In particular, it identified the importance of regular communication with patients – including ongoing engagement even if there was nothing new to report.” The quote is attributed to: Rashmi Kumar and Jo Burridge Patient and public involvement members, King’s Improvement Science

Waiting for heart surgery can be challenging, so King’s Improvement Science have been exploring how to improve this experience for patients.

Hear #PPI members Jo Burridge and Rashmi Kumar share their contributions and key findings from the work.👇

kingsimprovementscience.org/news/blog-co...

🚨Opportunity to take part in research! 🚨

The SURGE team are looking for individuals to help shape the research priorities in same day and urgent care⭐

Take part via WhatsApp, Survey or Focus Group!

🔗Visit the website to sign up: surgeworkforce.uk/priority-set...