Sanford Health is now offering both pediatric and adult general surgery outreach services in Dickinson, expanding access to specialized care for patients in the region.

buff.ly/oEW2Cbr

#MED #SanfordHealth #PediatricSurgery #GeneralSurgery

AI-Driven Marker Improves Outcomes for Pancreatic Cancer Nonproducers

by Thalji SZ, Aldakkak M (...) Kothari AN et 18 al. in JAMA Surg #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: jamanetwork.com/journals/jamasurgery/art...

Occult Nodal Disease in Gallbladder Cancer: An International Multi-institutional Analysis and Preoperative Risk Stratification - Annals of Surgical Oncology Introduction Accurate preoperative nodal staging remains challenging in gallbladder cancer (GBC), and a substantial proportion of patients presumed to be clinically node-negative have nodal metastasis at surgery. This study aimed to quantify the burden of occult nodal disease (OND)—defined as pathologic node-positive disease among clinically node-negative patients—and to identify preoperative factors associated with OND. Methods Patients who underwent upfront curative-intent resection with regional lymphadenectomy for GBC were identified from an international multi-institutional database. Among patients staged as clinically node-negative (cN0) on preoperative imaging, multivariable logistic regression was used to identify preoperative predictors of OND. CA19-9 and the systemic immune-inflammation index (SII) were log-transformed for modeling purposes. Results Among 187 patients, 142 (75.9%) were classified as cN0 preoperatively, among whom 47 (33.1%) had OND on final pathology. On multivariable analysis, higher ln(SII) (odds ratio [OR] 1.69, 95% confidence interval [CI] 1.05–2.86), higher ln(CA19-9) (OR 1.30, 95% CI 1.12–1.53), and preoperative jaundice (OR 3.68, 95% CI 1.21–11.76) were independently associated with OND. The observed OND rate increased stepwise with the number of elevated preoperative markers (SII > 890.2, CA19-9 > 37 U/mL, and jaundice): 17.1% with 0 markers, 44.8% with 1 marker, and 73.6% with 2–3 markers. Conclusions OND was present in approximately one-third of clinically node-negative GBC patients undergoing lymphadenectomy. Preoperative jaundice, elevated CA19-9, and elevated SII independently predicted OND and provided simple risk stratification. Incorporating these readily available markers into preoperative assessment may improve risk enrichment for OND and help guide additional staging and treatment sequencing.

Occult Nodal Disease in Gallbladder Cancer: Critical Insights

by Kawashima J, Yuza K (...) Pawlik TM et 9 al. in Ann Surg Oncol #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article:

High Variation in Expert Assessment of Peritoneal Malignancy

by Bhatt A, Sharma V (...) Glehen O et 42 al. in Ann Surg Oncol #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: link.springer.com/article/10.1245/s10434-0...

Improved Technique for Chronic Anal Fissures

by Liu R, Li J (...) Zhong S et 3 al. in Dis Colon Rectum #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: journals.lww.com/dcrjournal/abstract/9900...

Surveillance strategies for colorectal cancer need improvement

by Samur S, Gursel E (...) Neugut AI et 8 al. in BMJ Open #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: https://bmjopen.bmj.com/content/16/3/e111289

Tumor Debulking in Multiorgan Metastatic Colorectal Cancer Fails to Improve Survival

by Gootjes EC, Bakkerus L (...) Verheul HMW et 17 al. in JAMA #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: jamanetwork.com/journals/jama/article-ab...

Gastric Cancer Peritoneal Metastasis Management Consensus Established

by Boshier PR, Ann Chia DK (...) So JB et 40 al. in Br J Surg #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: academic.oup.com/bjs/advance-article/doi/...

New Checklist for Surgical Prehabilitation Reporting

by Gillis C, McIsaac DI (...) Fiore JF et 30 al. in Br J Surg #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: academic.oup.com/bjs/article/doi/10.1093/...

Prognostic Significance of Radiological Adjacent Organ Invasion in Resectable Left-Sided Pancreatic Cancer - Annals of Surgical Oncology Background The resectability of pancreatic cancer depends on the extent of vascular involvement. Left-sided pancreatic cancer (LPC) rarely invades major vessels but frequently involves adjacent organs. This study aimed to assess the prognostic significance of radiological adjacent organ invasion (RAOI) in resectable LPC. Methods This study included 162 patients who underwent distal pancreatectomy for resectable LPC between 2002 and 2020. Radiological adjacent organ invasion was defined as contact of the primary tumor or a continuous soft tissue density to the adjacent organs (stomach, adrenal gland, colon, or liver) on computed tomography. Clinicopathological factors and survival outcomes were compared between the RAOI (+) (n = 17) and RAOI (−) (n = 145) groups. Results The RAOI (+) group had significantly higher CA19-9 levels (279 vs. 33 U/mL, p = 0.005), larger radiological tumor sizes (37 vs. 21 mm, p < 0.001), and more frequently positive peritoneal cytology results (41% vs. 8%, p = 0.002). Overall survival (OS) in the RAOI (+) group was significantly worse than that in the RAOI (−) group (median survival time [MST], 25.9 vs. 67.2 months, p < 0.001). Among patients with negative cytology results (n = 141), OS was still significantly worse in the RAOI (+) group (MST, 33.5 vs. 71.9 months, p = 0.001). Multivariate analysis revealed CA19-9 levels ≥37 U/mL and RAOI as independent risk factors for poor OS. Conclusions Radiological adjacent organ invasion is an independent negative prognostic factor in resectable LPC and is associated with early systemic dissemination and worse survival outcomes. Radiological adjacent organ invasion (+) LPC may be considered a borderline resectable disease that requires intensive multimodal treatment strategies.

Radiological Organ Invasion Signals Poor Outcomes in Pancreatic Cancer

by Kitahama T, Ohgi K (...) Sugiura T et 6 al. in Ann Surg Oncol #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article:

Integrated Liquid Biopsy and Tumor Tissue Genomic Profiling of Appendiceal Cancer: cfDNA Burden, Mutation Landscapes, and Clinical Outcomes - Annals of Surgical Oncology Background Appendiceal cancer (AC) is a rare malignancy that often presents at advanced stages with significant histological variability influencing clinical outcomes. Precise genomic profiling is essential for accurate diagnosis and personalized patient management. This study interrogated DNA from appendiceal tumor tissue, buffy coat cells, and the cell-free DNA component of plasma using a 523-gene panel for comprehensive genomic profiling (CGP) to identify cancer-related genetic mutations in tumor and blood, evaluate tumor mutation burden, and determine genetic markers associated with histologic grade. Patients and Methods A total of 73 patients provided blood samples comprising cell-free DNA (cfDNA) and germline buffy coat cells (bcDNA) for analysis compared with tumor tissues available from 56 of these patients. Concordance of mutations between matched tumor tissue and plasma samples (n = 51) was assessed and tumor-specific and germline variants were classified using OncoKB™ clinical criteria to delineate oncogenic and therapeutically actionable variants [level 1 mutations with U.S. Food and Drug Administration (FDA)-approved therapy]. Additionally, cfDNA concentrations were tested for association with clinical and pathologic features and oncologic outcome including disease-specific (DSS) and progression-free (PFS) survival. Results Circulating tumor DNA (ctDNA) from plasma cell-free DNA demonstrated high concordance with tumor genomic profiling, reaching 98.4% concordance [median, interquartile range (IQR) 13.5, 21.5] overall and 85.7% (IQR 64.6, 100) for therapeutically actionable level 1 mutations. Prevalent appendiceal tumor-specific mutations included KRAS proto-oncogene, GTPase (KRAS) (41%), GNAS complex locus (GNAS) (30%), tumor protein p53 (TP53) (30%), and SMAD family member 4 (SMAD4) (29%). Tumor-specific TP53, SMAD4, and spectrin alpha, erythrocytic 1 (SPTA1) mutations strongly correlated with intermediate and high-grade histology, whereas GNAS mutations predominated in low-grade tumors. Germline analysis identified coding mutations shared among this patient cohort in notch receptor 4 (NOTCH4) (55%) and BRCA1 associated RING domain 1 (BARD1) (48%) genes, with zinc finger homeobox 3 (ZFHX3) (29%) and adhesion G protein-coupled receptor A2 (ADGRA2), DNA polymerase epsilon (POLE), and transcription factor 3 (TCF3) mutations (all = 23%) specifically enriched in intermediate and high-grade AC. Both histological grade and cfDNA stratified by concentration tertiles independently predicted progression-free and disease-specific survival. Plasma samples exhibited consistently lower variant allele frequencies than solid tumors, limiting sensitivity for discovery of novel mutations exclusively from plasma. Conclusions This study supports integrating comprehensive ctDNA assays into standard diagnostic and treatment pathways for AC using large gene panels. TP53, SMAD4, SPTA1, and GNAS mutations serve as prospective tumor-specific molecular classifiers for histological grade, while germline variants in NOTCH4 and BARD1 may further influence disease biology, with ZFHX3, ADGRA2, POLE, and TCF3 affecting grade stratification. Overall cfDNA concentration may serve as a potential prognostic biomarker in AC.

High Concordance of cfDNA and Tumor Profiling in Appendiceal Cancer

by Patel S, Petrosko P (...) LaFramboise WA et 16 al. in Ann Surg Oncol #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article:

Disparities in Surgical Care of Patients with Colorectal Cancer Liver Metastases - Annals of Surgical Oncology Background Up to 25% of patients with colorectal cancer present with liver metastases (CRLM), and 50% develop metastases over time. Surgical and ablative management of CRLM can be curative, but certain demographic and socioeconomic factors disproportionately hinder vulnerable patient populations from receiving advanced local therapies. Methods We queried the 2011–2021 National Cancer Database for cases of CRLM. We explored patient and facility characteristics associated with receipt of local intervention versus no intervention for metastatic liver lesions. Results Of 72,273 cases, 18.0% underwent hepatectomy or ablation. Controlling for patient- and center-level factors, non-Hispanic Black and Hispanic/Latino patients were less likely to undergo liver intervention than were non-Hispanic white patients (odds ratio [OR] 0.83 [95% confidence interval (CI) 0.78–0.88] vs. OR 0.92 [95% CI 0.85–0.99]). Patients treated at academic programs had significantly higher odds of liver intervention than did those in community cancer programs (OR 2.24 [95% CI 2.06–2.43]). Patients with private, Medicaid, Medicare, or other government insurance had higher odds of liver intervention than did uninsured patients (OR 2.07 [95% CI 1.86–2.30], OR 1.40 [95% CI 1.24–1.58], OR 1.81 [95% CI 1.61–2.03], OR 2.20 [95% CI 1.81–2.66], respectively). Patients in the highest income quartile were more likely to have liver intervention than those in the lowest quartile (OR 1.18 [95% CI 1.10–1.27]). Patients receiving liver intervention traveled farther than those receiving non-surgical care (p<0.001). Conclusion Surgical or local ablative management of CRLM is necessary to achieve cure for appropriately selected patients. However, this advanced liver interventional care is not equally distributed among patient populations. Significant socioeconomic and demographic disparities exist in the receipt of local liver interventional management among patients with CRLM and require further exploration to improve resource allocation.

Colorectal Cancer Liver Metastases Reveal Care Disparities

by Martinez AE, Webber A (...) DiBrito S et 3 al. in Ann Surg Oncol #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article:

Minimally Invasive Surgery Reduces Risks in Hepatectomy

by Shindoh J, Kobayashi Y (...) Matsumura M et 7 al. in World J Surg #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: https://onlinelibrary.wiley.com/doi/10.1002/wjs.70323

Tissue Factor as a Prognostic and Therapeutic Biomarker in Resected Pancreatic Cancer - Annals of Surgical Oncology Background Tissue factor (TF), a key initiator of the coagulation cascade, is frequently overexpressed in pancreatic cancer and linked to tumor progression and thrombosis. While TF has been recognized as a prognostic biomarker, its clinical relevance in surgically treated patients remains unclear. Methods We retrospectively analyzed TF expression in resected pancreatic cancer specimens from 265 patients, including those with and without preoperative therapy, using immunohistochemistry. Tissue factor expression was semiquantitatively classified as negative, low, or high. Associations with clinicopathological features, treatment response, and survival were evaluated. Results High TF expression was observed in 17.4% of cases and was significantly associated with elevated CA19-9, biologically borderline resectable disease, and lymph node metastases. These patients had shorter overall survival (median overall survival: 20.6 vs. 38.8 vs. 53.6 months, p < 0.001). High TF expression remained an independent predictor of poor prognosis (hazard ratio [HR]: 2.21, p = 0.0002). Tissue factor-negative tumors were associated with favorable outcomes, including long-term survival despite recurrence. Tissue factor expression decreased following preoperative therapy but did not correlate with histological response. Conclusions Tissue factor expression stratifies pancreatic cancer into biologically and prognostically distinct subgroups. While high TF expression indicates aggressive disease and poor survival, TF-negative tumors represent an indolent, treatment-sensitive subtype. These findings underscore the biological heterogeneity of pancreatic cancer and support TF as a clinically relevant prognostic biomarker.

Tissue Factor Levels Predict Survival in Pancreatic Cancer Surgery

by Kamiya M, Koizume S (...) Miyagi Y et 14 al. in Ann Surg Oncol #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article:

Vasopressin's Role in Edema Post-Liver Resection

by Aoki Y, Kawano Y (...) Yoshida H et 4 al. in World J Gastroenterol #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: www.wjgnet.com/1007-9327/full/v32/i10/1...

Circular powered staplers versus manual staplers in left-sided colorectal anastomoses: a systematic review and meta-analysis - Surgical Endoscopy Background Anastomotic leaks in colorectal surgery increase mortality, local cancer recurrence, and hospital readmission rate. The Echelon Circular Powered Stapler (PCS) is marketed to reduce anastomotic leaks by minimizing operator errors through powered systems. We reviewed current evidence on the use of PCS in left-sided colorectal anastomoses to determine if there is a reduction in anastomotic leak rates versus manual circular staplers (MCS). Methods This study followed PRISMA guidelines. MEDLINE, EMBASE, CINAHL, and OVID review databases were searched to January 2024. A broad search strategy for PCS versus MCS in colorectal surgery was used. Abstracts were reviewed for the primary outcome of anastomotic leaks, and data were extracted from full-text review. Statistical analysis was performed using RevMan 5.4 software. Results 109 articles were screened, 9 studies with 3110 patients were included. No randomized control trials (RCTs) were found. In pooled and sensitivity analysis excluding studies that used historic comparators, there was no significant difference in the rates of anastomotic leak (pooled RR 0.56, 95% CI [0.27–1.18], p = 0.13; sensitivity analysis RR 0.75, 95% CI [0.32–1.77], p = 0.52). Similarly, there was no significant difference in morbidity between PCS and MCS on pooled analysis (RR 0.84, 95% [CI 0.65–1.08], p = 0.17). However, on pooled analysis, there was a significantly lower rate of post-operative bleeding with the use of PCS (RR 0.2, 95% CI [0.08–0.51], p < 0.001). Conclusion The current systematic review and meta-analysis is unable to support the claim of lower leak rate with the use of PCS; however, there is preliminary evidence to indicate that powered staplers may decrease the rate of post-operative bleeding. Further evidence from RCTs investigating anastomotic leaks and bleeding rate with PCS and assessments of environmental impact should be conducted prior to the widespread use of powered staplers.

Circular Staplers Show No Leak Rate Advantage in Colorectal Surgery

by Samarasinghe N, Lin W (...) Ghuman A et 5 al. in Surg Endosc #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article:

Endoscopic versus surgical management for iatrogenic colonic perforations: a GRADE-assessed systematic review and meta-analysis of cohort studies - Surgical Endoscopy Background Iatrogenic colonic perforation is a rare but potentially catastrophic complication of colonoscopy (0.016–0.2% diagnostic; 0.15–5% therapeutic) with reported mortality of 15–25%. Rates may increase with expanding colonoscopy volume and advanced therapeutic interventions. Endoscopic closure is increasingly used, yet comparative outcomes remain uncertain. Methods Registered in PROSPERO (CRD420251233077). We searched six databases from inception to November 2025 for adult observational cohorts comparing endoscopic closure versus surgery. Outcomes included treatment success, mortality, major morbidity, reoperation, length of stay, and fasting duration. Two reviewers independently screened studies, extracted data, and assessed bias using ROBINS-I. Random-effects models pooled risk ratios (RR) and mean differences (MD); GRADE rated certainty. Sensitivity and geographic subgroup analyses assessed robustness and effect modification. Results Four retrospective cohorts (n = 123; 52 endoscopic, 71 surgical) from Portugal, Korea, and Malaysia were included across care settings. Treatment success showed no clear difference (RR 1.00, 95% CI 0.94–1.06; I2 = 0%; low certainty). Mortality was rare and imprecise (8 events; RR 0.26, 95% CI 0.06–1.16; I2 = 0%; very low certainty). Hospital stay was shorter with endoscopic management (MD − 9.23 days, 95% CI − 13.74 to − 4.73; I2 = 43%; low certainty). Fasting duration did not differ significantly and was heterogeneous. No geographic subgroup effect was detected (P = 0.95). Sensitivity analysis supported robustness, except for hospital-stay heterogeneity driven by referred cases in one study. Conclusions In observational cohorts, endoscopic closure was typically used for immediately recognized, smaller perforations in favorable clinical conditions, whereas surgery was preferentially used for delayed diagnosis, larger defects, or suspected contamination, introducing substantial confounding by indication. Accordingly, the pooled estimates should not be interpreted as evidence of equivalence. In carefully selected patients (immediate recognition, < 2 cm, no generalized peritonitis/instability), endoscopic closure appears to be a viable first-line strategy and may reduce length of stay. Prospective multicenter studies with standardized definitions and rigorous confounder adjustment are needed.

Endoscopic Closure vs. Surgery for Colonic Perforations

by Mirza W, Khan ME (...) Khan HM et 4 al. in Surg Endosc #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article:

Just in! 📢 Seeking Two #generalsurgery locums🍁 at 1) @RossMemorialHospital #LindsayOntario #KawarthaLakes & 2) @unityhealthto.bsky.social #TorontoOntario #ACS. Application deadlines: ongoing & April 10. #SurgeonJob #SurgeonJobs Details: rebrand.ly/x0g7kfj

Whole-blood transfusion cuts mortality in civilian trauma cases

by Ibrahim W, Meza Monge K (...) Idrovo JP et 8 al. in JAMA Surg #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: jamanetwork.com/journals/jamasurgery/art...

Obturator sign is a clinical finding that can help support the diagnosis of appendicitis.

Read: wikism.org/Obturator_Sign

Watch: www.youtube.com/watch?v=qlsD...

#medicine #Surgery #generalsurgery #emergencymedicine #meded #MedicalEducation #FOAMed #clinicalpearls

Endoscopic Necrosectomy: No Major Differences Found

by Tazinkeng N, Elmustafa F (...) Igbinedion S et 6 al. in Gastrointest Endosc #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: www.giejournal.org/article/S0016-5107(26)00...

Effective Strategies for Malignant Gastric Outlet Obstruction

by Brigida M, Crinò SF (...) Facciorusso A et 10 al. in Gastrointest Endosc #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: www.giejournal.org/article/S0016-5107(26)00...

Liver Transplant After Immunotherapy Shows Strong Outcomes

by Bhoori S, Rivoltini L (...) Mazzaferro V et 19 al. in J Hepatol #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: linkinghub.elsevier.com/retrieve/pii/S0168827826...

Surgical Sabermetrics Framework Enhances Training Outcomes

by Dick L, Howie E (...) Yule S et 7 al. in Br J Surg #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: academic.oup.com/bjs/article/doi/10.1093/...

ASO Education and Training: Taking the Next Step in Surgical Oncology Health Disparities Research: Identifying Root Causes and Targets for Actionable Change - Annals of Surgical Oncology The Society of Surgical Oncology and its membership are committed to reducing and eliminating cancer disparities. Over the past several decades, plentiful research has identified marginalized populations who are at an elevated risk of developing cancer, are less likely to receive recommended cancer screenings and guideline-concordant care, and populations who have inferior oncologic outcomes after cancer treatment. Despite monumental strides in improving cancer outcomes, cancer disparities unfortunately remain a reality. Continued strategic efforts are needed to identify the root causes of these disparities and develop interventions to ensure equitable cancer care for all patients. This monumental task requires multidisciplinary and transdisciplinary team collaboration, input from community and patient stakeholders, investments from healthcare and hospital administrative leadership, and financial sponsorship to ensure sustainability. In this review, we discuss tools that surgical oncologists can use in developing programs and interventions to champion eliminating cancer disparities to ensure equitable oncologic outcomes for all patients at risk or diagnosed with cancer.

Addressing Cancer Disparities in Surgical Oncology

by Cortina CS, Molina G (...) Willis A et 9 al. in Ann Surg Oncol #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article:

Celebrating #IWD2026. #InternationalWomensDay #GivetoGain #ILookLikeASurgeon #generalsurgery

StockBox #podcast featuring:

✅ Blencowe Resources #BRES
✅ Conroy Gold plc #CGNR
✅ One Health Group #OHGR
✅ Botala Energy #BTE

#graphite #gold #oromcross #uganda #Clontibret #copper #silver #orthopaedics #generalsurgery #spine #gynaecology #LNG #liquidnaturalgas #Investing

youtu.be/nWkjM4gfIn4

Risk Factors for Early Disease-Related Mortality Among Patients with Localized Pancreatic Cancer Resected After Neoadjuvant Treatment - Annals of Surgical Oncology Background Following neoadjuvant treatment (NAT) and resection with radical intent, not all patients with pancreatic ductal adenocarcinoma (PDAC) seem to achieve a meaningful survival benefit, as some experience very-early recurrence and succumb shortly thereafter. This study aimed to identify preoperative risk factors of mortality within 1-year after NAT and surgery. Patients and Methods Retrospective analysis of all patients who underwent radical resection for PDAC after at least 3-months of NAT between January 2015 and March 2023. Early-death (ED) was defined as disease-related mortality within 12-months of surgery, excluding surgery-related mortality. Receiver operating characteristic (ROC) curve analysis was used to determine statistically derived thresholds for continuous variables. Multivariable logistic regression was conducted to identify factors associated with ED, which were subsequently evaluated in an external cohort. Results Overall, 418 patients were included. After a median follow-up of 37 months (95%CI 34–39), 44 patients (10.5%) experienced ED, with a median survival from diagnosis of 17 months (95%CI 15–18) and a disease-free survival of 4 months (95%CI 3–4). Radiological tumor size ≥ 25 mm (OR 3.81, 95%CI 1.84–7.91, p < 0.001) and CA19-9 ≥ 100 U/mL (OR 2.93, 95%CI 1.41–6.05, p = 0.004) were independently associated with ED. These associations were confirmed in the external cohort of 473 patients (OR 3.93, 95%CI 2.39–6.45, p < 0.001 and OR 1.81, 95%CI 1.08–3.03, p = 0.023, respectively). Conclusions In this study, post-treatment CA19-9 ≥ 100 U/mL and tumor size ≥ 25 mm were associated with an increased risk of early-death after resection following NAT, representing warning signs in surgical decision-making and preoperative counselling.

Risk Factors for Early Mortality in Resected Localized Pancreatic Cancer

by De Stefano F, Belfiori G (...) Falconi M et 17 al. in Ann Surg Oncol #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article:

Immediate Endoscopic Necrosectomy Cuts Recovery Time in Pancreatitis

by Saito T, Fujisawa T (...) Nakai Y et 46 al. in Gastroenterology #Surgery #SurgSky #GeneralSurgery #MedSky

🪡 read our summary here
📖 read the article: linkinghub.elsevier.com/retrieve/pii/S0016508526...

Just in! 📢 FT #generalsurgery vacancy @mghtoronto.bsky.social @uoftsurgery.bsky.social #TorontoOntario🍁. Application deadline: April 1. #SurgeonJob #SurgeonJobs #colorectalsurgery #AcademicSurgery Details: rebrand.ly/x0g7kfj