Remember to catch out next online seminar on April 20, 3pm CEST!

Our new preprint on detailing the molecular mechanisms of how the carbonic anhydrase activates it's activity upon encapsulation into alpha-carboxysomes is now live. Congrats to Nikole and @guillawme.fediscience.org.ap.brid.gy !

Our latest paper is out! We built a large-scale mutational map of amylin to understand how sequence drives #amyloid formation, a process linked to type 2 #diabetes🩸📈📉. It’s a step towards connecting molecular mechanisms with human genetic variation in a systematic way.

Tune in to our next seminar on April 20 at 3pm CEST! We’ll hear from Prof. Tina Perica (@glukozica.bsky.social) and Isabella Menart (@isabellamenart.bsky.social)

Register to attend: tinyurl.com/PMCseminar2

Previous seminars: www.youtube.com/@PMCModularity

Our preprint is published in MSB! This time with the correct preprint post below! link.springer.com/article/10.1...

New OpenFold3 preview out! (OF3p2)

It closes the gap to AlphaFold3 for most modalities.

Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

Fabulous Friday is when your students tell you your course was great AND you get the message "we are pleased to inform you your manuscript is in principle accepted"..

A proteome-wide dependency map of protein interaction motifs - Nature Structural & Molecular Biology Ambjørn and Meeusen et al. functionally characterize all reported and a comprehensive set of predicted short linear motifs (SLiMs) using base-editing screens, identifying 450 reported and 264 predicte...

Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. www.nature.com/articles/s41...

Systematic Discovery of Motif-based Interactions of the Auxiliary Domains of USP Family Deubiquitinases The ubiquitin-specific proteases (USPs) family is the largest family of human deubiquitinating enzymes (DUBs). While most USPs are agnostic to polyubiquitin linkage-type, their substrate specificity i...

Finally out! Thrilled to share our collaboration with @kulathu.bsky.social, @orafurman.bsky.social, and N Davey. We screened auxiliary domains of USP family #deubiquitinases, revealing short linear motifs (SLiMs), contributing to specificity in complex assembly.
www.biorxiv.org/content/10.1...

Poster showing program for IDPSeminars on Feb 5th. Talks are: Lucia Strader: IDR sequence features of activation domains Heather Meyer: IDPs as environmental sensors and actuators in plants

IDPSeminas is back again TOMORROW!

Talks from Lucia Strader (@luciastrader.bsky.social) and Heather Meyer! Sign up at idpseminars.com.

Talks start at 1 pm EST / 7 PM CET!! Come learn about transcriptional adaptation and IDRs as environmental sensors and accuators!

US science after a year of Trump

"More than 7,800 research grants terminated or frozen. Some 25,000 scientists and personnel gone from agencies that oversee research." via @nature.com

Dark Age 2.0

Very much looking forward to the next PMC seminar, featring Benjamin Turk and Giorgia Massacci: www.proteinmodules.org/online-semin...

Not sure if Trump getting the Nobel Prize medal from Machado is more embarrassing for Trump, Machado, the Norwegian Nobel Committee, or the USA as a country.

In remembrance of Peer Bork  | EMBL EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.

This is such hard news to process. Such an amazing scientist and inspiration for so many of us.
www.embl.org/news/embl-an...

Very much looking forward to the next PMC seminar, featring Benjamin Turk and Giorgia Massacci: www.proteinmodules.org/online-semin...

Engineered base editors with reduced bystander editing through directed evolution - Nature Biotechnology Base editors are made more precise through deaminase and gRNA engineering.

Engineered base editors with reduced bystander editing through directed evolution - @geochurch.bsky.social @harvardmed.bsky.social @wyssinstitute.bsky.social go.nature.com/4qmupbv

It was fabulous to see everyone in Uppsala!

Last week, we wrapped up our Volkswagen Foundation–funded project with a wonderful final meeting in Uppsala, hosted by Ylva Ivarsson’s group. The photo shows members of our lab together with colleagues from the groups of @ivarssonlab.bsky.social , @hlouchova-lab.bsky.social and Florian Hollfelder.

Don't forget to catch out last seminar of the year on Monday Dec 8!

New paper “Proteome-wide model for human disease genetics” is now live at Nature Genetics: rdcu.be/eRu7K
popEVE (pop.evemodel.org) finds the needles in the haystacks of human genetic variation:

Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Applications for ERC Synergy Grants 2026: Facts and figures The ERC Synergy Grants 2026 call closed for applications on 5 November 2025. These are the preliminary data on the submitted proposals:

957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...

profaff.fr

The new ProfAff database is up and running. Although there are still many things to improve, it is a major upgrade.

PhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute. The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR

I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...

Catch our next seminar on November 10 at 3pm CET! You'll see presentations from Prof. Gideon Schreiber (@weizmanninstitute.bsky.social) and Alessandro Lussana (‪‬@alussana.bsky.social).

Register to attend: tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity

🚨🚨🚨
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.

If you're excited about evolution, genomics and biomedical research, this is your DN! 😃

Further info: www.evomg-dn.eu and 👇

The functional landscape of the human ubiquitinome Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

Don't forget to catch out next seminar on October 13 at 3pm CEST!

Can't wait to see you all there!!