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Posts by Mitchell Bijnen

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We are excited to announce a seminar in light of the 2026 International Day of Immunology, co-organized by SMyLe and @syis-ecr.bsky.social and sponsored by Miltenyi Biotec. Please join us on April 29th at 17.00 for talks by Prof. Dr. Melanie Greter and Dr. Pascale Zwicky (see flyer for more info).

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Your immune system fights battles every day, most of which you never notice. But what if we could understand them better & change the outcome?

#Neuroimmunology26 is where the brain and immune system are in constant conversation.

Now you can listen, be there, 19-20 Nov, Antwerp: vibbio.tech/4mg5iGk

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Pathophysiological roles of monocytes and macrophages in cancer - Nature Reviews Immunology Monocytes and macrophages adopt modular programmes in response to cancer cells, which can be viewed as an ‘infectious self’ challenge, and cues from the surrounding tissue environment as well as organ...

Even though they may have originated as part of the host defense. In the context of cancer, #macrophages mostly adapt tumor supportive roles, especially in advanced #cancer.

Pathophysiological roles of monocytes and macrophages in cancer | @natrevimmunol.nature.com

www.nature.com/articles/s41...

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Neuroinflammation in Health and Disease | Keystone Symposia Join us at the Keystone Symposia on Neuroinflammation in Health and Disease, June 2026, in Whistler, with field leaders!

Last chance to save $250 on #KSNeuroInflam26

Register by Apr 23 (11:59 PM MDT)
🔗 keysym.us/KSNeuroInfla...

Dive into neuroimmune interactions, inflammation in disease, and new therapeutic insights

🎥 @malutansey.bsky.social:
youtu.be/rGvSAqvbNzA

#neuroinflammation @kleinlabuwo.bsky.social

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Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca2+-mediated increases in astrocytic cholesterol
www.nature.com/articles/s41...

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M-CSF drives alveolar macrophage plasticity during development and cytomegalovirus infection www.biorxiv.org/content/10.64898/2026.04...

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Targeting gut pathology is effective in an Alzheimer disease model Nature Reviews Neurology, Published online: 10 April 2026; doi:10.1038/s41582-026-01208-9Butyrate prevents accumulation of amyloid-β pathology in the gut and brain in a mouse model of Alzheimer disease, research has shown.

New online! Targeting gut pathology is effective in an Alzheimer disease model

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Skull bone marrow changes in multiple sclerosis Nature Reviews Neurology, Published online: 09 April 2026; doi:10.1038/s41582-026-01207-wElevated levels of translocator protein in skull bone marrow are associated with greater neurological disability in multiple sclerosis, new work has shown.

New online! Skull bone marrow changes in multiple sclerosis

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Happy to share that the review we wrote with Rejane Rua is out in @cp-trendsimmuno.bsky.social ! 🎊
Check it out if you want to read about the contribution of skull in brain borders immunity! 🧠
@ciml.bsky.social

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Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin @cp-immunity.bsky.social www.cell.com/immunity/ful...

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New work from Maryanne Barasa et al shows that CX3CR1 deletion results in delayed microglial engagement and clearance of dying cortical neurons! 2Phatal continues to help us uncover important cell-cell interactions in vivo.
www.biorxiv.org/content/10.6...

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Growing our lab at Harvard Medical School & Mass General within the Genetics and Aging Research Unit led by Rudy Tanzi.
Seeking curious, driven #postdocs, visiting graduate students & interns to study how immune cells shape #Alzheimer's using next-gen human #neuroimmune systems.
Reach out!

2 weeks ago 2 1 0 0
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⭐️ Group Leader job opportunity ⭐️

We're currently recruiting for two Group Leader positions within our centre at Cardiff University.

Full information and to apply 👉️ buff.ly/JFbUtci

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https://rdcu.be/fckoZ

Great fun to write this review on Kupffer cells with Florent Ginhoux and Paul Kubes, covering origin, diversity and roles in immunity and metabolism, now out in @natrevimmunol.nature.com. Huge credit to Bruna Araujo David, Francesco Andreata and Camille Blériot for driving this work. t.co/rGpmTMRddV

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Pi16+ fibroblast-derived Csf1 shapes skin topography www.biorxiv.org/content/10.64898/2026.04...

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Postdoc Researcher: Pathogenesis of Alzheimer’s disease Emory University seeks a Postdoctoral Fellow to study Alzheimer’s disease mechanisms using molecular and cellular approaches in a leading neuroscience lab.

Emory University is recruiting a Postdoctoral Fellow to study Alzheimer’s disease mechanisms using molecular and cellular biology in the Li lab.

www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

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Postdoc: Computational Genomics of Alzheimers Disease VIB UAntwerp seeks a Postdoctoral Researcher in Alzheimer’s genomics to analyse large scale omics data and identify targets for early detection and treatment.

VIB UAntwerp is recruiting a Postdoctoral Researcher in Alzheimer’s genomics to analyse large scale omics data and identify targets for early detection and treatment.

www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

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Identity, ontogeny, and age-related changes in splenic white pulp macrophages in mouse and human spleen www.biorxiv.org/content/10.64898/2026.04...

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Ageing tissue fibroblasts support lung inflammaging Nature Reviews Immunology, Published online: 07 April 2026; doi:10.1038/s41577-026-01302-5In a study in Immunity, Allen et al. show that senescent lung fibroblasts in aged mice promote inflammaging by supporting a pro-inflammatory, ageing-associated T cell phenotype defined by granzyme K expression.

Ageing tissue fibroblasts support lung inflammaging

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📢NEW COLLECTION - NEUROIMMUNOLOGY

Nature Reviews Neurology is working with the International Society of Neuroimmunology (@ISNI_neuro) to include the best analysis and thought leadership on the breadth of neuroimmunology in this ongoing Collection!

www.nature.com/collections/...

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OBS Immunology
Immune cell ontogeny, and functional specialization of immune cells

🔹Laura Jiménez Gracia, PhD @cnag-eu.bsky.social
🔹Jing Chen
Moderator: Dr. rer. nat. Anna Salamero Boix @uocuniversitat.bsky.social

📅 Tuesday, April 14
⏰ 12 pm ET, 6 pm CET
💻 us02web.zoom.us/meeting/regi...

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Newly identified barrier cells seal off choroid plexus from CSF, rest of brain A long-overlooked layer of fibroblasts exists inside the choroid plexus of mice and humans, adding complexity to the area’s compartmentalization.

Fibroblasts play an important role in the compartmentalization of the choroid plexus, according to new work in mice.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/choroid-plex...

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Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer’s disease models Kim et al. demonstrate that reducing the expression of the transcription factor SPI1 (PU.1), a risk factor for Alzheimer’s disease (AD), in brain immune cells exacerbates AD-related pathology and impairs phagocytosis. Restoring the expression of three downstream target genes, Syk, Lyn, and Fcgr1, rescues defective Aβ clearance, revealing potential therapeutic targets.
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Great new work from our lab: #Microglia #glioblastoma interaction in vivo analyzed deep in the corpus callosum wirh #3photon microscopy by @felixnebeling.bsky.social

doi.org/10.1016/j.im...

#neuroscience 🧪 @dzne.science

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New work from our team, led by the incredible
@emily-hill.bsky.social out today
@cp-neuron.bsky.social. Including some exciting additions from our prepint. Thread below! authors.elsevier.com/a/1ms0u3BtfH...

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Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases Ali et al. analyze over 5,700 cerebrospinal fluid and plasma samples across Alzheimer’s disease, Parkinson’s disease, dementia with Lewy bodies, and frontotemporal dementia. They identify shared immune dysregulation and distinct pathway alterations, including glycosylation and interleukin signaling, and develop predictive models that accurately classify each disorder, highlighting biomarkers and pathways for therapeutic targeting.
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We are looking for motivated scientists to join our team, please reach out if you feel you are a good fit~

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Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone @cp-immunity.bsky.social
www.cell.com/immunity/ful...

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Glymphatic dysfunction: a unifying hypothesis for delirium - Nature Reviews Neurology Delirium presents a major challenge in intensive care and postoperative settings; however, the pathophysiology is poorly understood. In this Perspective, Nedergaard and colleagues examine the evidence...

www.nature.com/articles/s41...

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Big congratulations to Emanuela Pasciuto on receiving the 2026 Young Researcher Award from Stop Alzheimer / Stichting Alzheimer Onderzoek. 🙌 🎉

The award recognizes her research on microglia–T cell interactions in Alzheimer’s disease and comes with an additional €50,000 in support of this work.

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