It's more important than ever to publish your research on #WomensHealth. Explore these APS Publications Calls for Papers ➡️ journals.physiology....

#Alzheimers #Autoimmune #BreastCancer #Cardiovascular #HRT #Menopause #SexAsBiologicalVariable #Pregnancy #PCOS #Migraines #Endometriosis

Working on it….It gained my attention too.

What’s interesting about the response to the email: at the FBI, Patel, a hard-right Trump appointee and ally of Bannon, said no dice. Same at State but response came from Tibor Nagy, a moderate Trump appointee who was a career diplomat.

1/

Trump’s siege of science: how the first 30 days unfolded and what’s next Nature - The breakneck pace and devastating impact of the administration’s policy changes has researchers shocked.

The breakneck pace and devastating impact of the Trump administration’s policy changes has researchers shocked.

https://go.nature.com/4iboVwb

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order Nature - The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

Almost all grant-review meetings remain suspended at the US National Institutes of Health, preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.

https://go.nature.com/418B5Pm

MAGA Fan Zachary Levi Ripped After Begging Musk To Let 'Good' Trump Voters Keep Their Jobs Oh, puhh-leeeeze.

Yeah, that's not how any of this works.

Remote ischemic preconditioning attenuates ischemia-reperfusion injury-induced reductions in vascular function through release of endogenous opioids | Journal of Applied Physiology | American Physiological Society Remote ischemic preconditioning (RIPC) is a therapy characterized by repeated bouts of limb ischemia and reperfusion. RIPC protects against ischemia-reperfusion injury (IRI), and preclinical studies suggest that this is mediated through the release of endogenous opioids. We aimed to interrogate the role of endogenous opioids in RIPC-signaling in humans, using an arm model of IRI. We hypothesized that RIPC would attenuate IRI-induced reductions in brachial artery flow-mediated dilation (FMD) and that this would be prevented by systemic opioid receptor blockade. Eleven healthy adults (8 M/3 F, age = 28 ± 8 yr) completed three experimental visits in which IRI was induced via 20-min upper arm ischemia and 20-min reperfusion achieved via upper arm cuff inflation to 250 mmHg. FMD was measured at rest and again following IRI. During the control condition, RIPC was not performed. During the RIPC condition, RIPC was performed on the contralateral arm via four cycles of 5-min cuff inflation (250 mmHg) with 5-min reperfusion. During the opioid receptor blockade condition (naloxone), RIPC was performed in the presence of systemic opioid receptor blockade via intranasal naloxone (4 mg), which was administered during the first 5-min cycle of RIPC. The change in FMD from baseline versus post-IRI was compared between visits via a two-way repeated measures ANOVA (factor 1: time, factor 2: condition) followed by Tukey post hoc tests. IRI reduced FMD during the control (pre = 6.1 ± 2.4%, post = 3.5 ± 2.8%, P < 0.001) and naloxone (pre = 6.6 ± 2.7%, post = 3.5 ± 1.9%, P < 0.001) conditions but not during the RIPC condition (pre = 5.9 ± 2.2%, post = 4.9 ± 2.8%, P = 0.14). These findings demonstrate that RIPC provides vascular protection from IRI in humans through an opioid-dependent mechanism. NEW & NOTEWORTHY Remote ischemic preconditioning (RIPC) is a cardioprotective therapy characterized by brief cycles of limb ischemia and reperfusion. We demonstrate that a single bout of arm RIPC provides protection from ischemia-reperfusion injury-induced reductions in vascular function in healthy adults. This protection was attenuated when RIPC was administered in the presence of systemic opioid-receptor blockade via intranasal naloxone. These findings suggest that endogenous opioids contribute to RIPC-induced protection of vascular function in humans.

Well lookie here, my former student getting it done! Way to AJ!

ow.ly/VaMH50V4iSN