Check out this interesting work from @katiegelder.bsky.social and @danbose.bsky.social describing how IDRs within CBP temper acetylation. Very cool work!

Really pleased to share the *final* version of @katiegelder.bsky.social's super work, profiling the functional roles of #IDRs in CBP. Published today 🎉

🔗https://doi.org/10.1016/j.celrep.2026.117109

#IDRs #condensates #transcription #CBP #generegulation #enhancers (1/7)

Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar.
Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse.
www.biorxiv.org/content/10.6...

I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...

Researchers Identify New Target To Fight Antibiotic Resistance Carnegie Mellon University researchers, including Assistant Professor Drew Bridgs and graduate student Emmy Nguyen, have uncovered a vulnerability in bacteria that could pave the way for an entirely n...

CMU researchers have uncovered a bacterial vulnerability that could lead to a new class of treatments for antibiotic-resistant infections. Instead of killing bacteria, their approach targets pathways that control behavior. 🧪 #Biology #MolecularBiology
www.cmu.edu/mcs/news-eve...

I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.

What's larger, a protein or its templating mRNA ?

> The mRNA is much larger.

⬛ 𝐀 𝐬𝐞𝐧𝐬𝐞 𝐨𝐟 𝐬𝐜𝐚𝐥𝐞 -- 𝐪𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐢𝐧𝐭𝐮𝐢𝐭𝐢𝐨𝐧 & 𝐜𝐨𝐧𝐬𝐭𝐫𝐚𝐢𝐧𝐭𝐬 -- 𝐢𝐬 𝐚 𝐩𝐨𝐰𝐞𝐫𝐟𝐮𝐥 𝐞𝐧𝐚𝐛𝐥𝐞𝐫 𝐨𝐟 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡.

The figure shows myoglobin protein drawn to scale next to its mRNA template. The coding sequence of an mRNA ...

Roadmap for Condensates in Cell Biology Biomolecular condensates govern essential cellular processes yet elude description by traditional equilibrium models. This roadmap, distilled from structured discussions at a workshop and reflecting t...

Physicists' perspective on the future direction of condensates in Cell Biology.
arxiv.org/abs/2601.03677

2025 Year in Review 2025 was quite a year for the Mellon College of Science.

The Mellon College of Science had an extraordinary year in 2025.
From groundbreaking research to inspiring leadership, our faculty, students and community came together to advance science.
Explore the moments and milestones that defined the year: www.cmu.edu/mcs/news-eve...

New preprint led by super🌟 PhD student @eloisewells.bsky.social!

Here we explore using exon-skipping to remove upstream open reading frames (uORFs) and increase protein translation as a therapeutic approach for rare haploinsufficient disorders 🧬

To learn more see Eloise's 🧵 👇

Our Science paper is out!

Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group

News: bit.ly/4avnkAr and bit.ly/3XBGVHS

Great perspective by @vram142.bsky.social +K Zhang

Really looking forward to presenting our lab's most recent work on transcriptional control and a surprising non-enzymatic function for RNA polymerase II

RNA polymerase II coordinates histone deacetylation at active promoters Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.

Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...

Condensation and activator/repressor control of a transcription-regulated biomolecular liquid Cells operate in part by compartmentalizing chemical reactions. For example, recent work has shown that chromatin, the material that contains the cell's genome, can auto-regulate its structure by util...

We’re excited to share our new work in Soft Matter: doi.org/10.1039/D5SM...
We demonstrate how in vitro transcription can drive biomolecular phase separation — and how that phase separation in turn regulates transcription.

Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs Low-affinity transcription factor (TF) motifs are an important element of the cis-regulatory code, yet they are notoriously difficult to map and mechanistically incompletely understood, limiting our a...

We are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below:

(TLDR; low-affinity motifs matter as pioneers!)

Interested in pursuing a Ph.D. in Biological Sciences?
Join Carnegie Mellon University’s info session on Nov. 12 to learn how our program prepares students to become impactful scientific leaders.
apply-dc-mcs.mcs.cmu.edu/register/?id...

(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.

Henninger Explores Targeting RNA in Cancer Prevention, Treatment Jonathan Henninger, assistant professor of biological sciences at Carnegie Mellon, is finding ways to treat cancer with molecular precision.

CMU biologist @jhenninger.bsky.social is uncovering how RNA shapes gene expression and drives disease. His lab is developing tools to visualize transcription and design RNA-based therapies, paving the way for precision treatments for cancers like leukemia.
www.cmu.edu/mcs/news-eve...

Make an impact in Pittsburgh! We are seeking the next Head of the Dept. of Bio Sciences, with Ferra Executive Search. Nominate or refer now: apply.interfolio.com/174916

#STEMLeadership #HigherEd #LifeSciences #AcademicJobs #jobs #Pittsburgh #CarnegieMellonUniversity #FerraSearch #BiologyChair

Happy to share our latest in @natcomputsci.nature.com
led by (amazing) Ryan Krueger + colab w M. Brenner!

We introduce a framework to directly design intrinsically disordered proteins (IDPs) from physics-based simulations.
🧬 doi.org/10.1038/s435...
📰 www.mccormick.northwestern.edu/news/article...

Tenure-track Position in Biophysics at Carnegie Mellon University, Department of Physics Location: Pittsburgh, PA Open Date: Sep 19, 2025 Description The Department of Physics at Carnegie Mellon University invites applications for a tenure-track faculty position in biophysics. The appointment is intended to be at the Assistant Professor level, but exceptional candidates at a higher level may also be considered. We seek outstanding candidates with a strong record in cellular and subcellular biophysics. Topics of particular interest include, but are not limited to, uncovering how key characteristics of living systems arise from the interplay between supramolecular cellular structures, how the emergent cellular circuitry defines goals and enables robust decision making, and how metabolic resources are allocated. This encompasses understanding of how information is learned, stored, transduced, and processed across subcellular structures. Applicants with theoretical, data science, or experimental backgrounds within biological physics are encouraged to apply. The ideal candidate will strengthen and extend research programs of current biophysics faculty in the Department of Physics and collaborate with broader life science activities across many departments at CMU and the wider Pittsburgh area. More details on Interfolio: https://apply.interfolio.com/174360

I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪

Interfolio link: apply.interfolio.com/174360

PLEASE, share widely across the blue skies!

Let me briefly explain what we're looking for:

1/10

Please share with anyone who cares about NSF support for graduate students and take 30 seconds to sign and leave a comment.

The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP

jasonjwilliamsny.github.io/grfp2025/

I am extremely grateful for the support from the Samuel and Emma Winters Foundation! This award directly supports our research on targeting RNA sequences as potential therapies in multiple disorders, including cancer.

Preprint!

Inspired by condensates that form on specific DNA, we ask:

can we design multicomponent fluids to form distinct condensates on diff. surfaces?

i.e. perform classification by condensation ⚛️ 💻 exploiting phase transitions beyond compartmentalization!
arxiv.org/abs/2509.08100
(1/2)

esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions The genome is compacted in the nucleus through a hierarchical chromatin organization, ranging from chromosome territories to compartments, topologically associating domains (TADs), and individual nucl...

New preprint is up, led by former postdoc Braulio Bonilla.
We know these remodelers regulate nucleosome positions and occupancy, but do they have a role in regulating higher order chromatin structure? We take a peek for BAF and INO80C.
www.biorxiv.org/content/10.1...

NSF Graduate Research Fellowship Program (GRFP)

The GRFP lives!! (due end of October)
www.nsf.gov/funding/oppo...

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views RNA-binding proteins (RBPs) are best known as effectors along the entire gene expression pathway and as constituents of RNA-protein machines such as t…

www.sciencedirect.com/science/arti...

New in @pnas.org with @gladfelterlab.bsky.social @sneadlab.bsky.social ! 📢

Cells use condensates (dynamic compartments without membranes) to organize key reactions. Some condensates have core & shell layers… but how do such layers form? 🤔

👉 pnas.org/doi/10.1073/pnas.2504778122 (1/6)

2nd Genome Regulation through RNA Conference | Fusion Conferences Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...

The deadline is coming up for this fantastic meeting on all things RNA in gene regulation. Highly recommend!

www.fusion-conferences.com/conference/1...

Fragile Nucleosome Fall Seminars: September 10 Grace Bower, Kvon Lab @ UC Irvine, USA Jennifer Phillips-Cremins, UPenn, USA September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA Juanma Schvartzman, Columbia University, USA October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA Alex Federation, Talus Bio, USA October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland Seungsoo Kim, UC Irvine, USA November 5 Hannah Long, University of Edinburgh, UK Jeff Vierstra, Altius Institute, USA November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada Sarah Teichmann, University of Cambridge, UK December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain Jonathan Henninger, Carnegie Mellon, USA December 17 Rebecca Berrens, Oxford University, UK Jean-Benoit Lalanne, University of Montreal, Canada

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...