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Posts by James Gahan

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๐ŸŒŠ Exciting #PhDPosition in #PlanktonEcology at the University of Koblenz, Germany!

Work on marine protists with a mix of ๐Ÿ”ฌ wet lab and ๐Ÿ’ป bioinformatics in a 3-year, 60% position.

๐Ÿ“… Apply by 20 May 2026
Please repost/share ๐Ÿ™Œ
Link: tinyurl.com/yu27knau

#Protists #MicrobialEcology #PhD #Ecology

14 hours ago 10 6 0 0

Do you want to know when your favorite species activates its genome?

Just input its genome size (๐Ÿงฌ in bp) and egg volumen (๐Ÿฅš in um3) here!

ZGA_onset = -2.37 * log10(gDNA/EggVol) + 11.74

2 days ago 26 7 0 0

Now published. Congrats to Soham and all co-authors! www.science.org/doi/10.1126/....
@embl.org

4 days ago 52 20 2 1
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We thought we were just studying mesoglea biogenesisโ€ฆTurns out Nematostella has been hiding a sophisticated backup pressure valve! Work driven by the talented PhD student Soham Basu! @embl.orgโ€ฌ www.biorxiv.org/content/10.1...

10 months ago 68 21 1 8

The version of record is here @natcomms.nature.com
www.nature.com/articles/s41... ๐Ÿฅณ

Happy for this collaboration with @emmanuelhaillot.bsky.social and Stephan Schneider

At #EED24 in Helsinki we met. Instead of competing, we got our 2 stories togheter into a bigger one

#EvoDevo
#DevBio

4 days ago 36 10 3 0

Does it at least go against it a tiny bit in this (in your opinion)? Isnโ€™t there flow of information from the protein sequence to DNA sequence?

5 days ago 0 0 0 0

Reminder: PhD position in my lab is open for two more weeks.
How do germ cells use their own private transcription factors? Come help us find out.
Fully funded. Deadline May 1.
Flyer attached โ€” please boost! ๐Ÿ™

5 days ago 12 26 0 1
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Finally published at long last (at least in the pre-view version). Explore the wild and woolly world of archaeal histones! Interactive archaeal histone graph incluced rdcu.be/fdFjv. Congratulations to first author Shawn Laursen

1 week ago 70 27 3 0

Novel cell and tissue dynamics drive the unusual biology of the catch tentacle, an inducible organ of aggression found in the sea anemone Metridium senile www.biorxiv.org/content/10.64898/2026.04...

1 week ago 8 6 0 2
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That Nucleus looks bananas! Any good reference on that? Iโ€™d be very intrigued about whatโ€™s going on there.

1 week ago 2 0 1 0

Last day to submit an abstract! This is a meeting aimed at all career stages, but especially geared on early career scientists (PhD/postdoc), don't feel you need to have a perfectly polished story to present!

1 week ago 8 8 0 0
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Hands up if you love chromatin & structural biology ๐Ÿ™‹โ€โ™‚๏ธ

On Friday April 24th we will be joined by @kjarmache.bsky.social from NYU for his webinar 'Chromatin-Modifying Complexes in Gene Activation and Silencing'.

Register here: us06web.zoom.us/webinar/regi...

@activemotifusa.bsky.social

1 week ago 16 9 1 1
Event image card:
Human Development: Stem Cells, Models, Embryos
Date: 7 โ€“ 9 September 2026
Location: University of Warwick, UK

Event image card: Human Development: Stem Cells, Models, Embryos Date: 7 โ€“ 9 September 2026 Location: University of Warwick, UK

One month until early-bird deadline for @dev-journal.bsky.social & @wellcometrust.bsky.social-funded consortium HDBI's 2026 Meeting on Human Development: Stem Cells, Models, Embryos. Check out the programme biologists.com/meetings/dev... and register by 8 May www.biologists.com/meetings/dev...

1 week ago 13 11 0 0
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Postdoctoral Scientist | PNAC | Dr Ana Tufegdzic Vidakovic | LMB 2142 - Cambridge, Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12857096 Postdoctoral Scientist Salary ยฃ42,694 per annum pro rata Fixed term for 3 years MRC Laboratory of Molecular Biology, Cambridge, UK Applications are...

We are looking for a postdoc to join us on the quest for understanding RNA Pol II destruction machines! If you are curious why more than 80% of Pol II are removed from genes, check out the post below:

www.nature.com/naturecareer...

2 weeks ago 11 12 0 2

Congratulations, itโ€™s a very nice story!

1 week ago 1 0 0 0
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A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium - Genome Biology Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...

Our latest publication is now out at Genome Biology!
link.springer.com/article/10.1...

We uncover a unique association between a H3K27me3 reader complex and active transcription.
A thread with our key findings: (1/8)

#TEsky #Polycomb #transcription #smallRNAs

2 weeks ago 86 39 4 3

Are you chromat-in or chromat-out? ๐Ÿงฌ

Less than 2-weeks left to submit your abstract for this years @aicc-ireland.bsky.social symposium in @ucddublin.bsky.social ! We will be choosing talks & posters from these abstracts to present - with some fantastic prizes available.

Registration link below ๐Ÿ‘‡

2 weeks ago 5 3 0 0
MBE Call for Papers on the Major Transitions of Life

MBE Call for Papers on the Major Transitions of Life

MBE is excited to launch our newest Call for Papers on the Major Transitions of Life, covering all aspects of phylogenomic research.

๐Ÿ”— academic.oup.com/mbe/pages/call-for-papers-on-the-major-transitions-of-life

Guest Editors:
Davide Pisani
Anja Spang

#evobio #molbio #phylogenetics

2 weeks ago 23 14 1 0
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Undaria pinnatifida gametophyte

Undaria pinnatifida gametophyte

Our work on chromatin evolution in brown algae is now published in @natecoevo.nature.com! We show that developmentally complex brown algae evolved without epigenetic silencing pathways long thought universal, underscoring why non-model lineages are important to study. www.nature.com/articles/s41...

2 weeks ago 155 76 6 1
Image of a planarian, from Wiki.

Image of a planarian, from Wiki.

Do you do a PhD on Chromatin in this cool critter?

Work with @jordisolana.bsky.social @seanflynn.bsky.social, Magda Strauss and myself @lsiexeter.bsky.social on developing #singlecell #chromatin analyses to better understand pluripotency #planarians.
www.exeter.ac.uk/research/ins...

2 weeks ago 19 10 2 1

Apply now to join us in December for our workshop "Rethinking Cell Differentiation and Development: A Unicellular Perspective". This will be an intimate meeting (30 people total) and we hope will be a great place to discuss this topic.

2 weeks ago 10 8 0 0

Germ cells have their own versions of core transcription factors and fertility depends on them.
We're hiring a PhD student to figure out how! ๐Ÿ“ข
Fly genetics + proteomics + genomics. Fully funded.
Aarhus University ๐Ÿ‡ฉ๐Ÿ‡ฐ
Deadline May 1 ๐Ÿ‘‡

Please share with anyone who might be interested!

3 weeks ago 33 41 0 4
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Evolution of a distinct chromatin regulatory landscape in brown algae - Nature Ecology & Evolution Chromatin plays a central role in gene regulation, but chromatin systems are only known for a few model species. This study analyses chromatin regulatory landscapes in brown algal lineages to elucidat...

Chromatin plays a central role in gene regulation, but chromatin systems are only known for a few model species. This study analyses chromatin regulatory landscapes in brown algal lineages to elucidate their structural organization and evolution ๐Ÿงช www.nature.com/articles/s41...

3 weeks ago 30 19 0 1

Only 1 weeks to apply (April 7) for the joint Master program on "Evolutionary Genomics and Systems Biology" in Vienna.
studieren.univie.ac.at/en/admission...
Cool program with hands-on experience taught by leading scientists in PopGen, EvoDevo, Evolutionary Systems Biology.
Spread it!

3 weeks ago 8 7 0 0
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LondonEvoDevo meeting's website

May 5th: if you are around London, please join the London #EvoDevo symposium at QMUL / Charterhouse campus, as usual we will have selected talks and post-event ๐Ÿป. A warm up for #EED2026 in Glasgow. Registration ยฃ0, more info here: londonevodevo.co.uk

4 weeks ago 26 18 0 3

Itโ€™s a pity other countries donโ€™t adopt this idea. Maybe something to consider for our new funding agency @researchireland.ie ?

1 month ago 4 1 0 0
A dual role for CTCF in development CTCF is an essential DNA binding protein whose absence leads to embryonic lethality. CTCF is primarily known for its role in 3D genome organization where its N-terminal domain interacts with cohesin to anchor chromatin loops. How CTCF facilitates proper embryonic development remains unclear, necessitating temporal control to resolve its stage-specific functions. By combining gastruloids, an in vitro model of embryonic development, with a degron system to rapidly deplete CTCF at defined timepoints, we show that early CTCF depletion impairs early gastruloid morphogenesis. Surprisingly, ATAC-seq and time-resolved RNA-seq revealed that differentiation was unaffected. CTCF binding is strongly enriched at promoters of downregulated genes. Re-expression of a CTCF variant with an N-terminal truncation, incapable of looping, was sufficient to rescue the expression of CTCF-promoter bound genes and the defects in morphogenesis. However, extended culture (up to 168 hours) of gastruloids reconstituted with N-terminal truncated CTCF led to their collapse. Our work shows that CTCF has a dual function in early mammalian development: at early stages CTCF regulates developmentally important genes through promoter binding, while at later stages its looping function is required for correct development. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, https://ror.org/0472cxd90, 637587, 865459 Dutch Research Council, https://ror.org/04jsz6e67, 016.161.316, VI.C.222.049 Dutch Cancer Society, https://ror.org/0368jnd28, N/A

๐Ÿงต CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function โ€” and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...

1 month ago 112 55 7 4
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Our SPECIAL ISSUE on MOLECULAR EVOLUTION & ECOLOGY is out!
Editorial: @yehumoran.bsky.social, @berndpulverer.bsky.social et al
Reviews on Asgard archaea, epimutations, giant-virus/host dynamics, smartphone analogy for animal originsโ€ฆ
โ€ฆ& many related primary articles
link.springer.com/journal/4431...

1 month ago 21 8 0 4
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Today the EMBO Journal special issue on molecular ecology and evolution is finally published.
It was a pleasure coordinating this collection together with @berndpulverer.bsky.social and many outstanding authors.
Editorial: link.springer.com/article/10.1...

Cover art by @munafomarzia.bsky.social

1 month ago 27 13 0 1
EMBO startsย search forย its next Director โ€“ Features โ€“ EMBO The process to appoint the next EMBO Director is underway. The incoming Director will take office in February 2028, succeeding Fiona Watt, who has led the organization since January 2022

Interested in one of the top jobs in European biology?

@embo.org has opened a call for its next Director, to succeed Fiona Watt

Really spectacular opportunity! Spread the word...

www.embo.org/features/emb...

1 month ago 31 44 2 0