State-of-the-Art Review: Modern Approach to Nocardiosis—Diagnosis, Management, and Uncertainties Abstract. Nocardiosis is an uncommon yet potentially devastating infection. Nocardia tends to affect individuals with chronic lung disease or immunocomprom

Everybody take not of the review of @zyetmar.bsky.social !

academic.oup.com/cid/article/...

Nocardia arseniciresistens sp. nov., isolated from lead–zinc mine tailing. Find out more in #IJSEM:
doi.org/10.1099/ijse...

Interesting and engaging session of challenging cases in thoracic imaging with a super⭐️ panel of #chestrads at #ARRS25

My pick for most interesting case: 48 yo 🚹 with disseminated Nocardiosis 3 months s/p orthotopic heart transplant 🫀🫁🧠

State-of-the-Art Review: Modern Approach to Nocardiosis

⭐The duration of antibiotic treatment is understudied and based on few data ➡️ can be shortened if harms begin to outweigh potential benefits
⭐~5% develop recurrence ➡️ close monitoring needed

doi.org/10.1093/cid/...

#IDSky

MSCA Postdoctoral Fellowships 2025 Sorbonne Université met à disposition un dispositif d’accompagnement pour renforcer les projets Marie Skłodowska Curie Postdoctoral Fellowships.

Sorbonne Université @sorbonne-universite.fr has a program to accompany Marie Curie post doc applicants swll.to/N4kEIa . We have a subject on Natural Products from Actinomycetes so don’t hesitate to contact me if you might be interested

Nocardiosis is a rare but serious infection, affecting those with chronic lung disease or weakened immune systems. Incidence is rising; a comprehensive approach to diagnosis and management is essential.

#idsky

✅Nocardia
Thin, beaded, branching filamentous structures with peripheral clubbing
Gram+, GMS+, weak acid-fast+, PAS-, Aerobic
Filaments thinner (0.5-1μm) than Actinomyces, wide-angled, and non-septate
Intense neutrophilic response
#Pathology

Sporotrichoid Skin Infection Caused by Nocardia brasiliensis in a Kidney Transplant Patient Prompt and accurate diagnosis of Nocardia skin infections is important in immunocompromised hosts, especially transplant patients. The sporotrichoid form, which is otherwise known as the lymphocutaneo...

Yellowish white colonies growing on Sabouraud dextrose agar without chloramphenicol identified by 16SrRNA as #Nocardia brasiliensis. www.mdpi.com/2079-9721/6/...

20th International Symposium on the Biology of Actinomycetes ISBA2025

20th International Symposium on the Biology of Actinomycetes.

15-19 June 2025. Registration open

www.universiteitleiden.nl/isba2025/pro...

#actinomycetes #streptomyces #actinomycetota

DDX Nocardia can have a similar appearance on gram stain, it usually infects immunocompromised hosts; moreover, Nocardia is modified AFB positive whereas #Actinomyces is not.

Shorter looks better, also for Nocardia 😙 #AMSsky 👇🏻

Integrated analysis of proteome and transcriptome revealed changes in multiple signaling pathways involved in immunity in the northern snakehead (Channa argus) during Nocardia seriolae infection - PubMed The northern snakehead (<i>Channa argus</i>) is a valuable aquaculture species across certain Asian countries, contributing significantly to economic prosperity and dietary needs. However, its productivity faces significant challenges, particularly from diseases such as nocardiosis, caused by <i>Noc</i> …

Integrated analysis of proteome and transcriptome revealed changes in multiple signaling pathways involved in immunity in the northern snakehead (Channa argus) during Nocardia seriolae infection.

DOI: 10.3389/fcimb.2024.1482901

https://pubmed.ncbi.nlm.nih.gov/39717544/

Differential diagnosis of lymphocutaneous spread:
Nocardiosis N.brasiliensis, sporotrichiosis, cutaneous leishmania, MTB, NTM (marinum, chelonae, kansasii, fortuitum.

Less likely ddx: leprosy, cowpox, Staph aureus, strep pyrogens, tularemia, scedosporium, fusarium

#MicroSky: Actinomycetes & Streptomyces are true goldmines for natural products! A new TAR cloning system uses yeast K1 killer as a counter-selectable marker to directly clone large BGCs (35–67 kb), enabling faster antibiotic production in heterologous hosts. https://doi.org/10.1111/1751-7915.70067

Shorter vs. standard-duration antibiotic therapy for nocardiosis: a multi-center retrospective cohort study - Infection Purpose The prolonged treatment recommended for nocardiosis does not rely on strong evidence. Consequently, some clinicians opt shorter therapy in certain circumstances. We assessed the effectiveness ...

link.springer.com/article/10.1...

Short-term vs long term abx treatment for nocardia infections

#OncID #idsky

Metabologenomics-Driven Discovery of Nocardimicins from a Psychrophilic Nocardia sp. Strain A combined strategy of 2D-NMR-metabolomics-driven substructure tracking with genome mining led to the targeted discovery of 10 nocobactin-type lipopeptides (1–10) from the Arctic-derived phychrophillic Nocardia sp. L-016, among which 1–5 are new compounds, named nocardimicins S–W. The phenoxazole moiety in 1–10, featuring unique NMR values and correlations, was used as a probe for tracking nocardimicin analogues. The structures of 1–5 were established based on extensive MS and NMR spectroscopic analyses. The biosynthesis of nocardimicins (1–10) in Nocardia sp. L-016 is proposed to be achieved by the noc biosynthetic gene cluster, which is composed of two sub-gene clusters (I and II) separated by a 228 kb region. Compounds 1–10 showed moderate inhibition against human cancer cell lines of HCT116 and HepG2 with IC50 values in the range of 3.5–10.2 μM. This work provides an effective application of paired-omics technologies in the discovery of new natural products.

Metabologenomics-Driven Discovery of Nocardimicins from a Psychrophilic Nocardia sp. Strain
pubs.acs.org/doi/10.1021/...

#BacterioMed Nocardia farcinica isolated from a lung sample. Opportunistic bacteria originating in the environment (temperate climate).
It can be recognised by its downy aspect and the appearance of an orange pigment. Antibiogram in microdilution 48h incubation.
Active ATB: SXT, LZD, AMK.

Mapping the ultrastructural topology of the corynebacterial cell surface bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

www.biorxiv.org/content/10.1...

Multiple regulators control the biosynthesis of brasilicardin in Nocardia terpenica https://www.biorxiv.org/content/10.1101/2024.06.11.594307v1 Brasilicardin A, BraA, is a secondary metabolite produced by the bacterium Nocardia terpenica, and a

Multiple regulators control the biosynthesis of brasilicardin in Nocardia terpenica www.biorxiv.org/content/10.1101/2024.06....

Nocardia implantans sp. nov. isolated from a patient with pulmonary infection https://pubmed.ncbi.nlm.nih.gov/38904989/

Multiple regulators control the biosynthesis of brasilicardin in Nocardia terpenica https://www.biorxiv.org/content/10.1101/2024.06.11.594307v1 Brasilicardin A, BraA, is a secondary metabolite produced by the bacterium Nocardia terpenica, and a

Multiple regulators control the biosynthesis of brasilicardin in Nocardia terpenica www.biorxiv.org/content/10.1101/2024.06....

A modular toolkit for environmental Rhodococcus, Gordonia, and Nocardia enables complex metabolic manipulation. https://www.biorxiv.org/content/10.1101/2024.02.21.581484v1 Soil-dwelling Actinomycetes are a diverse and ubiquitous component of the global microbiome, but lar

A modular toolkit for environmental Rhodococcus, Gordonia, and Nocardia enables complex metabolic manipulation. www.biorxiv.org/content/10.1101/2024.02....

Crystal structure of a Class A beta-lactamase from Nocardia cyriacigeorgica https://www.biorxiv.org/content/10.1101/2023.10.02.560429v1 Nocardia are gram-positive bacteria from the actinobacterial class. Some Nocardia species can infect

Crystal structure of a Class A beta-lactamase from Nocardia cyriacigeorgica www.biorxiv.org/content/10.1101/2023.10....

Crystal structure of a Class A beta-lactamase from Nocardia cyriacigeorgica https://www.biorxiv.org/content/10.1101/2023.10.02.560429v1 Nocardia are gram-positive bacteria from the actinobacterial class. Some Nocardia species can infect

Crystal structure of a Class A beta-lactamase from Nocardia cyriacigeorgica www.biorxiv.org/content/10.1101/2023.10....

Glad to share our first publication on Nocardia drug resistance describing the first structure of a beta-lactamase from a clinical strain of N. cyriacigeorgica.

scripts.iucr.org/cgi-bin/pape...

Great collaboration with Dr. Oana Dumitrescu group from CIRI institute and CHU of Lyon

A modular toolkit for environmental Rhodococcus, Gordonia, and Nocardia enables complex metabolic manipulation. https://www.biorxiv.org/content/10.1101/2024.02.21.581484v1 Soil-dwelling Actinomycetes are a diverse and ubiquitous component of the global microbiome, but lar

A modular toolkit for environmental Rhodococcus, Gordonia, and Nocardia enables complex metabolic manipulation. www.biorxiv.org/content/10.1101/2024.02....