Anthropic secretly installs spyware when you install Claude Desktop — That Privacy Guy! Anthropic's Claude Desktop silently installs a Native Messaging bridge into seven Chromium browsers, including browsers Anthropic's own documentation says it does not support, and browsers the user ha...

#oopsie
Anthropic secretly installs spyware when you install Claude Desktop
www.thatprivacyguy.com/blog/anthrop...

Blog post on "The AI Rewrite Dilemma": lh3.github.io/2026/04/17/t...

Screenshot of Science commentary articleL Scientists stunned by ‘fundamentally new way’ life produces DNA. Newly discovered bacterial defense system challenges genetic code’s central dogma. Image: In a newly discovered bacterial defense system, paired strands of DNA (orange and cyan) are synthesized by two enzymes: One (yellow) uses an RNA template (beige) to guide the assembly of the nucleotide bases that make up DNA, while a second, highly unusual enzyme (light blue) uses its own amino acids as a template."

As a scientist, I am here to report that this headline is indeed accurate as I am in fact STUNNED!!

Wow. This is incredible. 🧪

"Newly discovered bacterial defense system challenges genetic code’s central dogma.":
www.science.org/content/arti...

Given a discussion on another thread, thought it might be useful to start a separate thread on how users are achieving higher ONT yields—extraction kits, size selection, sample type, basic stats, etc.

Anyone welcome to chime in.

@acritschristoph.bsky.social
@kirk3gaard.bsky.social

📣Registration and abstract submission now open for the Long‑Read Sequencing Uppsala 2026 meeting, taking place November 2–4!

For abstract submission, registration, and the preliminary program, please visit the conference website:

👉 lrua.se

Hello from Gothenburg! 🇸🇪
The ESHG team is at the last Site visit in Gothenburg to go through all the details for the conference #eshg2026. Looking forward to seeing you there!

Register and join us on-site in June: 2026.eshg.org/registration/

That's a great point. I think the RNA quality is pretty good in this case, but I'm not sure to what extent this could be a problem

Thanks. Yes I think you're right.. It would be nice though if it was possible to get really long direct RNA reads

Thanks, will take a look

What's the current best strategy to sequence complete transcripts in the ~20kb range? Should we attempt generating full length cDNA, or go for direct RNA on ONT? I suppose it will be a challenge in any case..

Single-molecule peptide sequencing through reverse translation of peptides into DNA - Nature Biotechnology Peptides are sequenced by converting each amino acid into amplifiable DNA barcodes.

Would I have called it reverse translation? No. Do I think it is? Also no. Is it cool? Heck yes.

www.nature.com/articles/s41...

In collab w @hdashnow.bsky.social, we have a new preprint out on tandem repeat (TR) mutagenesis! Using HiFi sequencing, we profiled nearly 8 million TR loci across four generations of a large CEPH/Utah family and identified 1,270 de novo expansions and contractions.
www.biorxiv.org/content/10.6...

Roche Axelios1 Run Pricing: Not A Knockout - Yet? By far the most awaited news at AGBT was Roche's reveal of the pricing scheme for Axelios 1 consumables: what would be the structure and how...

Roche Axelios1 Run Pricing: Not A Knockout - Yet?

#AGBTGM26

🧬💻

omicsomics.blogspot.com/2026/03/roch...

Illumina Constellation Becomes TruPath Genome Illumina is rebranding their Constellation mapped read technology to TruPath Genome and launching it into the marketplace. Priced at $395 pe...

Ooof - I was sloppy on the Illumina TruPath Genome piece - easy to blame AGBT fatigue but that's a lazy excuse. The following errors have been corrected

omicsomics.blogspot.com/2026/02/illu...

1. TruPath doesn't have an "e" in it. About 14 mistakes = including the title!

Illumina launches TruPath Genome, setting a new standard in genomic insight

Illumina officially launches TruPath, their pseudo-long read sequencing kit (formerly called Constellation), at #AGBT #AGBT25

www.illumina.com/company/news...

Nallo: a Nextflow pipeline for comprehensive human long-read genome analysis academic.oup.com/bioinformati... 🧬💻🧪 github.com/genomic-medi...

This looks really interesting

Nallo: a Nextflow pipeline for comprehensive human long-read genome analysis AbstractMotivation. Long-read sequencing (LRS) is increasingly used for human medical research and clinical diagnostics, due to its capacity to generate co

Say hello to Nallo - our Nextflow pipeline for long-read WGS analysis!👋 It handles both ONT and PacBio data and we’re using this for rare disease and population projects in Sweden. A big team effort by Felix Lenner, Anders Jemt et al.🧬💻 academic.oup.com/bioinformati...

Element Joins the High-Throughput Market with the VITARI Platform Back at JPM Element teased that they would be coming out with the VITARI, a benchtop sequencer capable of generating whole genomes for $100. This would best Illumina’s list price of $200 with the N…

Element reveals more information about their VITARI platform, a foray into the high-throughput sequencing market. sandiegomics.com/element-join...

AGBT 2026 Preview

#AGBT26 #AGBT2026 #AGBTGM26

🧬🖥️

omicsomics.blogspot.com/2026/02/agbt...

Portrait of Tove Fall, SciLifeLab Group Leader and Uppsala University Professor, with greenery all around.

🧪 In two new studies on 28,000 individuals, researchers are able to show how 11 genetic variants affect gut microbiome.

@tovefall.bsky.social (SciLifeLab/@uu.se) led one of the studies.

Learn more in the Uppsala University press release here:
www.mynewsdesk.com/uu/pressrele...

Long-Read Sequencing Uppsala, November 2–4, 2026 #LRUA26: Empower your research with long-read sequencing technologies and connect with experts, peers, and industry leaders in Uppsala this November.

Save the date! The Long‑Read Sequencing Uppsala Meeting (#LRUA26) is happening Nov 2–4, with a great lineup of invited and selected speakers

Stay tuned — registration and abstract submission will open soon🧬🖥️

lrua.se

Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries Eukaryotic gene expression is orchestrated by RNA polymerases (RNAPI, II, and III) and associated factors, yet their real-time dynamics remain obscure. Using single-molecule tracking in living yeast, ...

🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...

New tool from @alexsweeten.bsky.social to find and classify all your satellites: "AniAnn's: alignment-free annotation of tandem repeat arrays using fast average nucleotide identity estimates"
📄 www.biorxiv.org/content/10.6...
📦 github.com/marbl/anianns

Hello #FOG2026! We love hearing how #HiFiSequencing supports key moments in your work—from breakthroughs to impact.

Let’s partner to support your research—stop by today. #TheresHiFiForThat

@sptlabtech.bsky.social @adameur.bsky.social

ONT Axes P2 Solo, Roiling Community Oxford Nanopore has a serious case of user community unrest, triggered by the announcement that the P2 Solo (aka P2s) will be phased out sta...

ONT Axes P2 Solo, Roiling Community
🧬🖥️

omicsomics.blogspot.com/2026/01/ont-...

🚀 Registration is now OPEN! longtrec.eu/VALT/
Join us in Valencia, Spain for the first symposium dedicated to #LongReadsTranscriptomics 🧬, with a dream set of keynote speakers.
@pacbio.bsky.social @nanoporetech.com @elixir-europe.org @iscb.bsky.social @hitseq.bsky.social @i2sysbio.es

JP Morgan 2026 Roundup

🧬🖥️

omicsomics.blogspot.com/2026/01/jp-m...

Asking google who is more suave, Ian Dunt or Dorian Lynskey, with -noai in the search term, returns no hits

Asking google who is more suave, Ian Dunt or Dorian Lynskey, returns some AI blather

In case useful @iandunt.bsky.social , @soniaz.bsky.social has just shown me how to turn off the AI summary in google search! Just add -noai. Just did a simple test comparing you and @dorianlynskey.bsky.social

Catch 4 presentations featuring HiFi data at #FOG2026 on Jan 28 with Anna Lindstrand, @robpitceathly.bsky.social, @whaerty.bsky.social, and @adameur.bsky.social. Learn how #LongReadSequencing is enabling diagnostics and uncovering new therapeutic opportunities.

Full details here: bit.ly/3MAm7y1