Illumina officially launches TruPath, their pseudo-long read sequencing kit (formerly called Constellation), at #AGBT #AGBT25
www.illumina.com/company/news...
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Hashtag
#AGBT25
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🚀 Exciting news from #EASIGEN-DS team!
Last week, Ivo Gut and Tuuli Lappalainen @tuuliel.bsky.social, members of #EASIGEN-DS, attended the prestigious #AGBT25 meeting in 📍Marco Island, Florida.
If you want to know more – check out the post below!
#Genomics #EASIGEN #Innovation #Research
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This is from the Illumina #AGBT25 workshop about their ST tech.
But, from our observations, under heavy lateral diffusion (real or simulated), clustering on large sets of genes (i.e. “whole transcriptome”) leads to niche- rather than cell-type clustering.
This might be problematic.
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Waiting for my flight so I have time to reflect on the past week #agbt25
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My top-THREE non-Roche-SBX #AGBT25 takeaways:
1. Spatial Genomics is the new shiny object
2. Methylation detection was ubiquitous and varied
3. Normalization of libraries improved but was iterative
If you're looking for Bioinformatics help, give me a call!
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Thanks for a great meeting. Looking forward to seeing you all next year at #AGBT26 on Feb 23-26 2026!! #AGBT25 | #AGBTGM
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A reminder that the illumina spatial solution might be second half 2026. #AGBT25 #Spatial #multiomics #NGS
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See ya later #AGBT25 #AGBTGM. Another great year of genomics tech and science! You guys are some of my favorite people!
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One big npn-announcement from Illumina $ILMN at #AGBT25 is that they could come up with a nanopore method in 2030. Oxford @nanoporetech.com is available today.
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The sun is setting on #AGBT25. But that doesn't mean the action has to stop. We invite intrepid researchers everywhere to keep up with us at our website below!
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Just saw a talk by Andrew Pask at #AGBT25 #AGBTGM on marsupial genomics, evolution, and gene editing for conservation. Completely mind blowing work. Taking both genetic editing and conservation work into a new frontier.
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#AGBTGM #AGBT2025 #AGBT25 AP: quoll may go extinct in next 10 yrs. Eats toads but introduced cane toad is toxic and kills quoll. Toxin impacts ATP1A1 gene- should be able to introduce resistance. 1 single bp change increased resistance 6000x. Will help reduce spread of cane toads.
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#AGBTGM #AGBT2025 #AGBT25 AP: Have worked on other marsupial genomes. Find closest living relative to extinct animal. About 500K edits relative to dunnart. Even though dunnart is tiny relative to thylacine, both are marsupials so have tiny babies and can maybe serve as surrogate.
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#AGBTGM #AGBT2025 #AGBT25 AP: role of animals in landscape shown by removing and reintroducing wolf in Yellowstone. Exceptional genome resources for thylacine. Have baby preserved in alcohol. Also found mother in alcohol. Have gotten long DNA from teeth. Have 9x long read sequence, 18 gaps remain.
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#AGBTGM #AGBT2025 #AGBT25 AP: tool kit for de-extinction - T2T genomes, gene editing, ART, stem cells, biobanking. Thylacine became extinct in 1936, apex predator so led to ecosystem destabilization. Impact on tasmanian devil because sick individuals are not removed leading to spread of tumors
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#AGBTGM #AGBT2025 #AGBT25 Andrew Pask from univ of Melbourne talking about marsupial genomics including thylacine. 21% of native land mammals in Australia are threatened with extinction.
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#AGBTGM #AGBT2025 #AGBT25 JD: Try to assemble genome. 3.5M PacBio reads., 26M Illumina reads. Growth of trophozoites inhibited by nitroxoline but restored by Fe or Cu supplementation. CDC guidelines have been changed to nitroxoline and stock held for use as needed
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#AGBTGM #AGBT2025 #AGBT25 JD: posted results on medRxiv and was found by grandmother of 6 yo patient. Treated patient.
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#AGBTGM #AGBT2025 #AGBT25 JD: Repurposing screen of 2017 drugs identify nitroxline to kill trophozoites. Not approved in US. Used for UIs. New patient identified several years later. Emergency IND to give nitroxoline. Saw near full recovery and still surviving 3 yrs later.
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#AGBTGM #AGBT2025 #AGBT25 JD: metagenomics for diagnosing neurological disease. Balamuthia mandrillaris (trophozoites) found after brain inflammation caused death of 74 yo woman
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#AGBTGM #AGBT2025 #AGBT25 JD: Track cell lineages in zebrafish using light sheet imaging. Also, metagenomic analysis made fast and made available worldwide to enable improved pathogen surveillance and rapid outbreak response.
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#AGBTGM #AGBT2025 #AGBT25 Joe Derisi from UCSF talking about genomic explorations in infectious diseases. Global organelle profiling shows subcellular localization and remodeling at proteome scale chnages with infection. Not seen in transcription or proteome changes.
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#AGBT25 Maybe breakfast on Thursday you might gaze out on the Gulf of Mexico and see the USS United States heading to Mobile Alabama to be stripped of of copper, windows and then sunk to make a coral reef. She might hug the coast.
Just look for the tug "Vinik No. 6" on website MarineTraffic
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So many DNA-methylated assays at #AGBT25. Wait until they hear about methylated RNA.
#bioinformatics
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#AGBTGM #AGBT2025 #AGBT25 JB: cached DNA shows better genotype concordance via SRS than does frozen DNA. Caching maintains full length RNA transcripts.
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