This is super exciting. JAK1 inhibitor turns out to be a very effective treatment for TEN/SJS

www.nature.com/articles/s41...

Hi #IDSky! I’m putting together my usual top 10 ID papers of this year list again (this time will post here not in the other world).

Please tell me your candidate papers - practice changing paradigm shifting or dogma challenging!

Resistance profiles of carbapenemase-producing Enterobacterales in a large centre in England: are we already losing cefiderocol? AbstractBackground. Carbapenemase-producing Enterobacterales (CPE) pose difficult therapeutic challenges. We aimed to characterize antimicrobial resistance

New paper from my colleagues at UCLH

Nearly 70% (!!!) resistance to Cefiderocol in NDM positive bacteria.

Cefiderocol...we hardly knew ye...

Perfect timing for World Antimicrobial Awareness Week #waaw24 #IDSky

academic.oup.com/jac/advance-...

a woman in a pink dress is sitting in a chair with a sign that says be Alt: a person in a pink dress is sitting in a chair and unfurls a comically long list of paper

Very possible. Probenecid is the ritonavir of the kidney. The list of DDIs

Same! This last week has felt like a reunion - but one you want to go to...

Incredible graphic - the myriad of ways that bacteria defend themselves against antibiotics.

14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell

www.sciencedirect.com/science/arti...

Morning #IDSky what is your preferred rounding structure for teaching services? Would love to know why in comments 👇

1️⃣ AM team rounds
2️⃣ PM team rounds
3️⃣ BID team rounds
4️⃣ Keep it flexible

📊 Show results

Yet she persisted

Thanks! Nice clean board

This is the persistence I love to see

More joy here!

A 4 by 4 grid 16 words. The words are skunk, leech, dapto, TMP/SMX, mosquito, tedizolid, racoon, ceftobiprole, linezolid, the Cullens, tick, vanc, ceftaroline, bat, fox, doxy.

ID Connections #2
Same game as the NYT Connections but with ID content and unlimited guesses.
connections.swellgarfo.com/game/-OBYIEo...

Safety, tolerability and pharmacokinetics of subcutaneous meropenem as an alternative to intravenous administration AbstractBackground. Subcutaneous delivery of antibiotics is a practical alternative to IV administration. Meropenem is commonly used to treat infections ca

Interesting! SubQ meropenem.

“Subcutaneous meropenem appears to be well tolerated and has a favourable pharmacokinetic profile. Either 1.5 g twice daily or 3 g as a 24 h subcutaneous infusion could be considered for future evaluation.”

academic.oup.com/jac/advance-...

Safety of early oral ambulatory treatment of adult patients with bloodstream infections discharged from the emergency department | Antimicrobial Agents and Chemotherapy Randomized trials have unanimously shown the benefits of oral antibiotic treatments for stable patients with bacteremia (1). However, transition to oral therapy has been usually performed after several days of intravenous treatment—frequently up to 7 days (2)—highlighting the need for evidence of the safety of earlier oral treatments (3).

Can we treat patients with low-risk BSI discharged from the ED with a fully-oral course of antibiotics?

[Spoiler: Yes!]

🆓🔓Our recent article on #OralIsTheNewIV! 👉🏻 journals.asm.org/doi/10.1128/...

Food for thought for #AMSsky #IDSky

Clinical Experience With Penicillin Skin Testing in a Large Inner-City STD Clinic Objective.  —To establish (1) the prevalence of positive penicillin skin tests among outpatients with well-defined but variable history of penicillin allergy and (2) the reproducibility, safety, a...

My Top 5 Antibiotic Allergy Papers - #5
▶️Gadde et al. JAMA 1993; 270 (20)
▶️ A paper before its time. Skin testing for #penicillinallergy in patients with ID indication!
▶️ 7.1% + ; PPL & MDM utilisation; safety (1/128+ required adrenaline); Allergy LOSS WITH TIME.
jamanetwork.com/journals/jam...

That is correct.

2 Brucellosis infections
1MERS viral PNA

Rational included in articles is religous reasons.

Good timing, I'm creating ID trivia questions currently

In the Middle East and Africa drinking camel urine and/or milk is not rare. In a study of 66 pts w cancer who drank a mixture of camel urine and milk, 3 developed infections.

Let me know if you want to guess or just want the answer :)

To get hopefully some #peniicillinallergy #drugallergy folk over to 🦋 from X I am going to list my top 5 #antibioticallergy papers of all time - starting tomorrow! Stay tuned 👀

To say I am on the edge of my seat is a massive understatement. What time is it in Australia? Is it tomorrow yet?

Oh! Interesting! Love this.

Love the oral choice! I struggle using oral 2nd/3rd gen cephs because folks are used to tiny doses (250-500mg BID) and there limited if any) any PK/PD studies with bigger doses to make up for the 50% bioavailability.
We are making big strides w high dose 1st gens (1g Q8-12) w cefadrox and cefalex.

Very happy to report that @sidpharm.bsky.social and @mad-id.bsky.social is here. Waiting on SHEA...

TEMs are definitely in the mix in CO. ESBLs are still more common.
We tend/try to use cefepime on TEM phenotypes to save the carbs.

New graph algorithms for analysis of the genomes and pangenomes of bacteria and their mobile elements. at University of Bath on FindAPhD.com PhD Project - New graph algorithms for analysis of the genomes and pangenomes of bacteria and their mobile elements. at University of Bath, listed on FindAPhD.com

I'm advertising a PhD studentship (open to international students) working on long read pangenome / assembly algorithms in bacteria. Would suit someone with maths/compsci/coding background. Aptitude + interest more important than experience.
Details here:
www.findaphd.com/phds/project...

Hello #IDSky #MedSky #PharmSky!

We are MAD-ID, striving to educate 🎓 and promote 🏆 infectious diseases and antimicrobial stewardship clinicians and researchers!

Looking forward to the bright future of our ID community on this platform 🦋

Here’s pack 2! Still in progress - will update more tomorrow.

It’s been a fun day. Love seeing our community rebuild here! Goodnight Bluesky. 🦋💤

Along the lines of what others have started, here's a #SkyRx starter pack - if I'm missing you let me know!

go.bsky.app/DTkEEWG

Let's get MAD-ID over here too!

No experience personally. Lit search alternative

Tinidazole pubmed.ncbi.nlm.nih.gov/37070857/