"Just five more minutes" at the computer… and suddenly you’ve skipped lunch and stayed up all night. Burnout isn’t a trend. It’s your brain screaming "stop." Sound familiar?

#gamedev #indiedev #devlife

Drug-resistant fungus Candidozyma auris confirmed to spread rapidly in European hospitals: ECDC calls for urgent action The latest survey from ECDC, the fourth of its kind, confirms that Candidozyma auris (formerly Candida auris) continues to spread quickly across European hospitals.

Drug-resistant fungus Candidozyma auris confirmed to spread rapidly in European hospitals: ECDC calls for urgent action www.ecdc.europa.eu/en/news-even...

certified

Female Athlete Triad: 1) ↓Energy availability (calories < exercise needs), 2) ↓Estrogen (amenorrhea), 3) ↓BMD. Pathway: ↓EA → ↓Leptin → ↓GnRH → ↓Estrogen → ↑Osteoclasts → Fragility fracture. Dx: EA<30kcal/kgFFM/day, oligo/amenorrhea, Z≤-2.0/Fx. Tx: ↑Calories to ↑BMI>18.5 + OCPs.

#ClinicalPearl

Vaccine triggers fierce response to fight brain tumor » McKnight Brain Institute » University of Florida UF-developed mRNA vaccine quickly reprogrammed the immune system to attack glioblastoma.

Five years ago, a very close relative died of a glioblastoma brain tumor at the age of 13. Today would have been his 19th birthday. And now comes news that an mRNA vaccine is being trialed to treat this very (incurable) malady. Fingers crossed.

mbi.ufl.edu/2024/05/01/v...

Metoclopramide Contraindicated in Parkinson’s: D2 antagonist → exacerbates parkinsonism (bradykinesia, rigidity) + acute dystonia/akathisia + TD | CI: PD; bowel obstruction/perforation (d/t ↑ motility) | Safer antiemetic: Ondansetron (5-HT3 antagonist)

#Pharma #Neuro #GI #ClinicalPearl #DeepSeek

#Physiology #HeartSounds #Verify

Widely split S2 (classic example — RBBB): Delayed RV depol → prolonged RV ejection → P2 delayed → fixed/widened S2 (minimal inspiratory gain) | Cath: A2 (LV pressure < aortic pressure) → delayed P2 | DDx: RBBB, pulmonic stenosis, ASD, RV pacing

#MedEd #ClinicalPearl #DeepSeek #AIGenerated #2025

#Pulmonary #MedEd #ClinicalPearl #DeepSeek #AIGenerated #2025 #Verify

Neonatal RDS: Diabetic mother (↑insulin→↓SP-B/C) / prematurity (<34wks) → type II dysfunction → ↓surfactant (DPPC+SP-B/C) → hyaline membranes | Tachypnea+grunting + CXR: ground-glass/air bronchograms | Rx: Surfactant (Poractant🐽[Curosurf], beractant🐮)+CPAP | Prevention: Antenatal betamethasone

𝐃𝐍𝐀 𝐏𝐨𝐥 𝐈𝐈𝐈 → 5′→3′ elongation + 3′→5′ exonuclease (proofreading); Lagging strand → Okazaki frags w/ RNA primers; 𝐃𝐍𝐀 𝐏𝐨𝐥 𝐈 → 5′→3′ exonuclease excises RNA primers + replacement synthesis; 𝐋𝐢𝐠𝐚𝐬𝐞 → seals nicks (phosphodiester bonds). Loss of Pol I → persistence of RNA oligomers, ↑ mutation rate.

DNA Replication Enzymes (Prokaryotic):
𝐇𝐞𝐥𝐢𝐜𝐚𝐬𝐞 → unwinds dsDNA @ oriC; 𝐓𝐨𝐩𝐨𝐢𝐬𝐨𝐦𝐞𝐫𝐚𝐬𝐞 𝐈𝐈 (DNA gyrase) → relieves +supercoils; 𝐒𝐒𝐁𝐏 → stabilizes ssDNA; 𝐏𝐫𝐢𝐦𝐚𝐬𝐞 (RNA pol) → lays RNA primers;

#MiniMedSchool #USMLE #InternalMedicine #MedicalEducation #Helicase #DNAgyrase #SSBP #Primase #DNAPol #Ligase

Important article

Netanyahu been real quiet about #BelieveWomen lately

Or the book is an interview

Wolffian Ducts Want Androgens

🧬 Male dev:
• Testosterone → internal (epididymis, vas deferens, seminal vesicles)
• DHT → external (penis, scrotum, prostate)
❌ No T = no vas deferens
🧪 5α-reductase def: female ext genitalia, intact Wolffian ducts (T still acts internally)
#USMLE

ECMO

VA-ECMO
• ❤️+🫁 support
• Ind: Arrest, Cardiogenic Shock, PE, myocarditis, BTT/LVAD
• Access: FV → FA

VV-ECMO
• 🫁 only
• Ind: ARDS, refractory PNA/asthma, BTLT
• Access: FV → IJV

CI:
• Irrev CNS inj, end-stage CA, DIC, active bleed (AntiCoag. req'd; e.g.: heparin drip)

#DeepSeek, #ChatGPT

TdP Triggers:
1. QT-prolongers (IA, III, macrolides, APs, methadone, ondansetron)
2. ↓K⁺, ↓Mg²⁺, ↓Ca²⁺
3. Organophosphates, arsenic, malnutrition, diarrhea, congenital LQTS

⸻

Tx
• MgSO₄ IV (even if Mg²⁺ nl)
• Replete K⁺/Mg²⁺
• Pace/isoproterenol (if brady)
• Shock if VF
#DeepSeek #ChatGPT