Did you know that the 3 billion base pairs of DNA in human cells is copied in about 8 hours? But how? Our DNA Replication paper model shows you how!
Find out more here: buff.ly/a036Nj3

#EduSky #DNAreplication #DNApolymerase #helicase #primase #iteachbio #biologyteacher #genetics #DNA #celldivision

Researchers show that lactate-induced #lactylation of the #helicase BLM at Lys24 enhances #HomologousRecombination repair and drives #anthracycline resistance, while #irinotecan counteracts this by suppressing BLM lactylation. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

DNA Replication Enzymes (Prokaryotic):
𝐇𝐞𝐥𝐢𝐜𝐚𝐬𝐞 → unwinds dsDNA @ oriC; 𝐓𝐨𝐩𝐨𝐢𝐬𝐨𝐦𝐞𝐫𝐚𝐬𝐞 𝐈𝐈 (DNA gyrase) → relieves +supercoils; 𝐒𝐒𝐁𝐏 → stabilizes ssDNA; 𝐏𝐫𝐢𝐦𝐚𝐬𝐞 (RNA pol) → lays RNA primers;

#MiniMedSchool #USMLE #InternalMedicine #MedicalEducation #Helicase #DNAgyrase #SSBP #Primase #DNAPol #Ligase

Spending quality time with good friends at the #Helicase conference in beautiful Lisbon #RNA

Metabolic tuning enables immediate adaptation to energy stress in yeast In Saccharomyces cerevisiae , glucose depletion induces metabolic reprogramming through widespread transcriptional and translational reorganization. We report that initial, very rapid translational si...

Cool!
#Metabolism #Reprogramming #Energy #Stress #NTP #Helicase #Translation #BuddingYeast

www.biorxiv.org/content/10.1...

Left-most: Almost full-body sketch of Silicon Herakles, sporting a cynical, stoic expression. He says "Hm" as he looks down at . His appearance is based off of helicase diagrams. Top-right: Silicon Herakles. Genome Hex: Savage Pellucidar Right: Crude, simple sketch of Silicon, meant to show his beetle-like wings. Bottom-right: Silicon Herakles without his outfit, sporting the same cynical expression. He has 3 dotted lines starting from the top of his nose.

He looks like he hates life (and is about to make that everyone else's problem).

#art #oc #monstrocity #silicon #siliconherakles #savagepellucidar #fat #oldman #belly #bald #chubby #chub #big #villain #bodysuit #latex #rubber #helicase

New #Breakthrough article from @Woodsonlab.bsky.social shows how the E.coli RNA DEAD-box helicase unfolds unstable RNAs to fuel ribosomal RNA remodeling and the search for the native, protein binding structure! #Ribosome #RNA #Helicase 👉 Full article: https://doi.org/10.1093/nar/gkaf104

Structural Chemistry of Helicase Inhibition Helicases are essential motor enzymes that couple nucleoside-triphosphate hydrolysis with DNA or RNA strand unwinding. Helicases are integral to replication, transcription, splicing, and translation o...

An excellent perspective on different classes of #helicase #inhibitors 🧪
pubs.acs.org/doi/10.1021/...

DDX21 at the Nexus of RNA Metabolism, Cancer Oncogenesis, and Host–Virus Crosstalk: Decoding Its Biomarker Potential and Therapeutic Implications DDX21, a member of the DEAD-box RNA helicase family, plays a pivotal role in various aspects of RNA metabolism, including ribosomal RNA (rRNA) processing, transcription, and translation. Its diverse f...

#DDX21 #RNA #Helicase

www.mdpi.com/1422-0067/25...

Great #Helicase conference in beautiful Lisbon next summer 2025! Details here. helicasesconference.com See you there.

Side view of a potted plumosa #fern on a table.

#DNA after #helicase action