Very cool. Congratulations!

Exciting to see this out in its final form! Wonderful work led by @probablycarmen.bsky.social. Want to know why protrusions are better at initiating immune signaling in #Tcells? Look no further. Link to Carmen’s 🧵 on the preprint bsky.app/profile/prob...

Our #UExM efforts with @gautamdey.bsky.social & @moorefound.bsky.social featured in @nature.com this month.

Beyond the #science, every image is a thing of beauty.

I think a world-tour exhibition has to happen at one point.

#Expansion #Microscopy

From left to right: Bettina Rockenbach, President of the Leopoldina, Meritxell Huch, Regine Kahmann, Deputy Speaker of Class II – Life Sciences, and Roland Lill, Speaker of Class II – Life Sciences.

‪
On April 15th, @leopoldina.org welcomed its new members of Class II Life Sciences. Meritxell Huch @merihuchlab.bsky.social, director @mpi-cbg.de, is among them and received their membership certificate together with fifteen other new members. Congratulations! 🎉 Photo: Marlene Gawrisch | Leopoldina

It happens. I'd say that is a grant that needs work. From what I hear re-submission of grants rates C is rarely successful, but people do get a B, take the feedback, make the grant better and get it.

Lipid-CLEM by @mathilda95.bsky.social on the Cover of @natcellbio.nature.com! Link to article: www.nature.com/articles/s41...

Original image from 2011 of what I just had seen under the microscope when I ran into @oliverrocks.bsky.social’s office to show him. Turned out he’d observed this too, had no idea what it was either, but was just as stunned and curious as I was.

This is how it all started...

/1

2 year ban for B score is harsh, in my opinion

Dear Lipid and Membrane Enthusiasts,

There is only one month!! left to register and submit your abstracts for the @embo.org Workshop “Lipid Code to Life”, which will be held from September 7–11, 2026, in Dresden, Germany.

Workshop program and registration page: meetings.embo.org/event/26-lip...

Applying for an ERC grant in the 2027 competitions: what you need to know The ERC plans to launch the grant competitions under its 2027 Work Programme between July 2026 and June 2027, with the calls for proposals introducing several changes to the eligibility rules for appl...

That is one way to get funding rates up, I guess.
erc.europa.eu/news-events/...

Check out our new release on BioRxiv
co-lead by @pm-mueller.bsky.social

👉 rb.gy/lnrizk

special🙏 to
Severine Kunz #MDC
@leventallab.bsky.social
@andimicroscopy.bsky.social
@ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM

Are the days of discovering new cellular structures over?? /1

The world's current business model in a nutshell

This looks extremely interesting conceptually.

Transport of sphingolipids by yeast Npc2 supports phase separation of the vacuole membrane The yeast vacuole membrane forms ordered microdomains that facilitate microlipophagy under nutrient limitation. We previously found that this process …

New paper where we report that Npc2 - a shuttle-like lipid transfer protein - in yeast directly transports sphingolipids to the = vacuole membrane during formation of microautophagy-linked ordered domains #lipidtime
www.sciencedirect.com/science/arti...

So, I wouldn't call it head in the sand approach. More like right time, right place, right people.

There are quite a few studies that did try to estimate crosslinking probabilities & it's difficult - what allowed us to put hard numbers on it are (a) looking at a lipid in a defined binding pocket of a protein and (b) working with Carla... one of the best people using native MS.

1/ Excited to share our preprint! 🥳

Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine

www.biorxiv.org/content/10.6...

Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬

Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social

We are looking for an experienced light microscopy specialist, motivated to support our users in the Advanced Light Microscopy Facility at EMBL Heidelberg.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j... -closing date 11 May 2026 @eurobioimaging.bsky.social @globalbioimaging.bsky.social

I agree

🇩🇪🚨 #JobAlert Leite das gerne an deine Kollegen weiter!
Wir suchen eine:n Techn. Mitarbeiter:in / Facharbeiter:in (m/w/d) für unser internationales Team bei Physics of Life!

Bewerbt euch bis zum 05. Mai. Mehr Infos hier: tud.link/rywtux

#joboffer #wearehiring #jobdestages #sachsenjobs

#lipidtime!

Many thanks for the shout-out! That really means a lot!!!

Fentanyl's Membrane Behavior

Is part of fentanyl’s high activity as an opioid agonist because it slides through cell membranes even more quickly than morphine?

Image of a calcium calibration curve, calcium concentration traces of individual cells and lifetime images of cells

📣 New preprint alert! Co-authored by @spalaciosm.bsky.social and @andreacaldarola.bsky.social :
Quantitative imaging of calcium dynamics with a green fluorescent biosensor and fluorescence lifetime imaging
www.biorxiv.org/content/10.6...

Lipid-trap mass spectrometry identifies lipid–protein interactions in cells @natcellbio.nature.com @kingscollegelondon.bsky.social
www.nature.com/articles/s41...

Exploiting internal symmetry can be a powerful approach to analyse convergence in MD simulations.

If two conformational states are symmetry related, their kinetic and thermodynamic properties should be the same. If one doesn't enforce this during analysis this provides a useful test. 1/n

Median survival went from 6 months to 13 months. It may not sound like much, but for metastatic pancreatic cancer, this is big, IMO. We finally have something solid to build on in this field.

🍰Read also the News & Views article written by Aubrey Weigel:
👉https://rdcu.be/fdcf4
bit.ly/4tNdLn9

Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains.
bit.ly/4moYLJH