Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!

Always in awe of you, this is beautiful! Congrats Helen! 🎉

Add our first pre-print to your reading list?

Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social!

Please share: tinyurl.com/3h8r7f5y

Huge congrats Morgan and so well deserved! Really excited for you! 😁🎉

Mechanistic studies on axonemal dynein transport to motile cilia - Dunn School Over 30 groups work at the Dunn School to uncover the molecular and cellular mechanisms underlying disease. Discover which research groups are accepting students for our next round of applications.

The annual Dunn School DPhil studentship competition for 2026 is open for applications.

We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.

www.path.ox.ac.uk/project/mech...

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

Excited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing.

Glad to be featured in the Editors’ Highlights!

www.nature.com/articles/s41...

#splicing #cryoEM

Postdoc position in my lab: investigating how the microtubule motor protein dynein-2 works in cilia.

Here's dynein-2 at work translocating microtubules - how is this activity regulated? How does dynein-2 malfunction in disease?

Find out more and apply:
my.corehr.com/pls/uoxrecru...

Thank you so much Xin for your kind words and also for beautifully shining the light on FHF in your own work!

Thanks Max!

Great to see our story on dynein & kinesin co-dependence published www.nature.com/articles/s41..., and absolutely chuffed that it's made the front cover (thanks NSMB!). A brilliant News & Views too by Steven Markus www.nature.com/articles/s41.... Collab between @carter-lab.bsky.social & Straube lab🔬

Huge congrats both - so good to see this out in final form @chrisvanhoorn after all the meticulous and clever ways you approached this beast of an organelle. Stunning 🤩

Closing the scissor-shaped curve: Strategies to promote gender equality in academia Gender inequality in STEM fields remains pervasive and undermines the ability for talented individuals to excel. Despite advances, women still encounter obstacles in pursuing academic careers and reac...

Reading the paper in Cell about how to close the scissor plots in gender representation at senior academic positions, I feel just a touch of pessimism. Having reached a level of seniority (middle management) I didn’t think I ever would, I read these great ideas wanting more, much more /1.

Please share this PhD opportunity in my new lab in Bristol, using protein design/ engineering to understand and build molecular motors to control intracellular transport. Working with @markdodding.bsky.social and Prof Dek Woolfson.
www.findaphd.com/phds/project...
www.swbio.ac.uk/biomolecular...

Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c

A huge achievement - congrats to all! 🥳

Thanks Adam for this and for being so welcoming 😊

Thanks a lot Ennio!! Grateful for the support 😊

Grazie mille Paolo! :-)

Thanks so much Alex, appreciate it! 😊

Ah, so kind, thanks a lot Girish - and likewise!

This graphic summarises what the South West Biosciences Doctoral Training Partnership offers prospective PhD students: training, 4 years funding, placement opportunities, structured first year training, interdisciplinary projects, collaborations with industry, fieldwork opportunities, a supportive cohort environment. Also has a link to the swbio website (www.swbio.ac.uk) and application deadline details. The graphic depicts life sciences cartoons ranging from DNA to animals, plants, and a range of cell types (all in lime green on a dark green background).

⌛ Deadline is Midnight (23:59pm GMT), Wednesday 11 December 2024. Also, underrepresented groups are particularly encouraged to apply #BlackinSTEM. Lab website coming soon for more details & future opportunities. Reposts highly appreciated!

Funded PhD- Coordination Between Actin and Microtubule Motors During Endocytosis at University of Bristol on FindAPhD.com PhD Project - Funded PhD- Coordination Between Actin and Microtubule Motors During Endocytosis at University of Bristol, listed on FindAPhD.com

The position is either funded by a UoB scholarship or SWBio DTP - to be considered for both pools of funding apply separately for each of these. Secondary sup. is the brilliant @markdodding.bsky.social. 📧 E-mail Ferdos.abidali@bristol.ac.uk for informal enquiries & 📝apply here tinyurl.com/yvzeb2kw.

This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

The intraflagellar transport cycle - Nature Reviews Molecular Cell Biology Intraflagellar transport (IFT) ensures delivery of selected proteins into cilia. The IFT protein complexes IFT-A and IFT-B polymerize at the base of the cilium to form an anterograde train that facili...

Our review of Intraflagellar transport is out now! We cover lots of the recent advances in our understanding of IFT, and where we think there are still some gaps.
www.nature.com/articles/s41...

International Day of LGBQTIA+ People in STEM is TODAY! 🏳️‍🌈

And for those in Bristol (@bristoluni.bsky.social), check out the LGBTQ+ STEM mini-conference on Wednesday in C42 (BMS building), 1-5pm.
Register via: forms.office.com/e/LxuMpa6nQF

BSCB Women in #CellBiology prize 🧪
Deadline extended (15th Nov)
The deal: UK-based scientist, running lab for < 7 years with 1+ senior author publication.
Do you know someone who should be nominated? Maybe it's you?
Details (a bit out of date): bscb.org/competitions...

❗️Exciting science alert!! Come join us at the BCA Winter Meeting at the MRC Laboratory of Molecular Biology, Cambridge, 6th December. Short talks available - a great opportunity for early career researchers to present.. bit.ly/4fDEqfZ

This year’s UK Membrane Trafficking Meeting is on Dec 16th at King’s College London (Guy’s Campus, London Bridge).
Registration closes 9th December. Sign up is here.
estore.kcl.ac.uk/conferences-...
Thanks go to @J_Cell_Sci for sponsoring student/postdoc prizes!