The number of NIH competitive awards is down 50% from 2025, and down ~70% from prior years. Even if they catch up by the end of the year, only wealthy institutions can bridge these huge funding gaps.They're killing science-and violating the constitution-by weaponizing the bureaucracy
mRNA vaccines continue to show major promise.
In a small Phase 1 trial led by Dr. Balachandran, some patients with pancreatic cancer (one of the deadliest cancers) reached 6-year survival.
This is why sustained investment in science & research matters.
tinyurl.com/f4n4anhk
Most biologics are glycosylated and some of them heavily. In this “fresh off the press" #glycotime preprint we look into how a filter that accounts for glycosylation explicitly in 3D can help reduce lab costs and increase the efficiency of de novo binder design pipelines. Short 🧵 ⬇️ 1/7
1/28 How do you optimize a dynamic protein property that emerges from multiple states? Our finally published paper in @NatureComms takes on one of the hardest problems in protein engineering with phage assisted evolution: evolving allosteric switches🧵
Had a long month of news? Settle down with our comforting review describing how membrane proteins get made in mammalian cells.
www.annualreviews.org/content/jour...
New @sloanfoundation.bsky.social grants: Exemplary Pathways to STEM Graduate Education.
Up to $500,000 for orgs focused on helping remove obstacles for undergraduates who want to pursue advanced STEM degrees.
Deadline is June 1. Please share & apply if this is you! sloan.org/programs/hig...
Having a hard time keeping up with the fast-moving field of origin of eukaryotes/Asgards archaea? Our new perspective article can help, we review the status of research over the last decade and where it's going.
The archaeal roots of eukaryotic life
www.pnas.org/doi/10.1073/...
By 2028, all 4-character PDB IDs will be exhausted.
After that, all new entries will receive extended IDs: 12 characters total, formatted as pdb_ + 8 alphanumeric characters (pdb_1000axyz)
Test it from PDB Beta Archive
Read more: www.wwpdb.org/news/news?ye...
Follow up to Doug Hanahan’s visionary article about the stages of cancer development from back in the 1990s
www.cell.com/cell/fulltex...
🧵
Notice of Temporary Extension to Early-Stage Investigator (ESI) Eligibility Period:
grants.nih.gov/grants/guide...
The cell biologist’s guide to detecting and modulating membrane #phospholipids. New review from Michael Worcester, Gerald Hammond @gerryhammond.bsky.social and colleagues: rupress.org/jcb/article/...
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
Hi fellow membrane protein #StructuralBiology people!
Do you use maltoside detergents / model them in your stuctures? Watch out! ⚠️
Most PDB models of LMNG and GDN are wrong ❌, yet continue to be re-used. Spread the word!
See more: doi.org/10.1021/acsc... (w. @sebvidalchem.bsky.social ) #cryoEM
"Previously, proposals for research grants were generally required to undergo at least three external reviews by scientists from outside the agency. Now, two reviews are enough and, under some circumstances, one can be an internal review by a scientist at the NSF." 🧪
Clifton Poodry (Seneca), a co-founder of SACNAS, & designed & implemented the NSF program that was the template for the Minority Supplement for NIH grants.
& Jo Handlesman, who co-founded a women faculty mentoring program, the teaching program Tiny Earth, & started the natl microbiome initiative
this looks like a dream come true for my lab. Can't wait to try it out!
Delighted to report that our group's passion project over the last 6+ years to make DNA cloning more accessible, efficient, and scalable using a software-assisted workflow called CloneCoordinate is now out in ACS Synbio!
pubs.acs.org/doi/10.1021/...
This seems like a big deal. A chance to get one more proposal in the hopper for …when?
“we will be rescheduling all October and November grant application submission deadlines (specific dates to be announced in a future Notice). “
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
#Wolbachia has puzzled scientists with its power to rewire insect reproduction. What if I tell you that we found one of the keys Wolbachia use to rewire its host AND a small molecule inhibitor uses this key to mimic what this microbe has mastered for millions of years.
www.cell.com/cell-reports...
Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out:
eeik.fa.us2.oraclecloud.com/hcmUI/Candid...
Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.
Katz Early Stage Investigator Research Project Grant is back. Share with your ESI colleagues!
grants.nih.gov/grants/guide...
Great set of follows here. Diverse perspectives on all this [waves arms wildly]...
congratulations Needhi!!
delighted to share our most recent publication, and the first first-author publication from rising star Carolyn Curley, now out in Biomacromolecules. Biophysical techniques, stimuli-responsive IDPs, a step toward ELP biosensors @pubs.acs.org pubs.acs.org/doi/10.1021/...
Wes Sundquist is one of the good guys. He is a scientists scientist and has carefully, passionately, and consistently carried his science out with this goal in mind. A cure for AIDS that is available to all.
This is an amazing recognition for him and for the @utah.edu where he has done his work.
