Weighted-incidence syndromic combination antibiogram (WISCA) to guide antibiotic regimens for empiric treatment of prosthetic joint infections: A retrospective cohort study Prosthetic joint infections (PJIs) are now routinely treated with oral antibiotics, but selecting empiric regimens is challenging, including for treatment of culture-negative PJIs. Although antibiogra...

📣 What is a #WISCA?

It's something you should probably use for culture-negative prosthetic joint infections. Local antibiograms alone can be misleading.

This WISCA showed that doxycycline + a fluoroquinolone offer best coverage for #PJI

#IDSky #clinmicro #ortho
www.cmi-comms.org/article/S295...

Research in context panel for Lancet paper "Adult obesity and risk of severe infections: a multicohort study with global burden estimates". Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

People with obesity at 70% higher risk of serious infection with one in ten infectious disease deaths globally potentially linked to obesity, study suggests.

Find out more 👉 spkl.io/63323AtTtt

Preventing Long COVID With Metformin Chaichana et al conducted a sequential trial emulation to assess whether starting metformin after severe acute respiratory syndrome coronavirus 2 (SARS-CoV

#Medsky🧪 #IDsky #endosky #immunosky #pharmasky #publichealth Repurposing a chronic diabetes medication for acute viral infection may seem counterintuitive, so the briefly review the rationale
@cidjournal.bsky.social
academic.oup.com/cid/advance-...

Preventing Long COVID With Metformin Chaichana et al conducted a sequential trial emulation to assess whether starting metformin after severe acute respiratory syndrome coronavirus 2 (SARS-CoV

academic.oup.com/cid/advance-...

Fedora Pharmaceuticals Highlights First-in-Class Antibiotic at Conference | Contagion Live Fedora Pharmaceuticals is presenting new preclinical data at the IMARI conference demonstrating that its lead candidate, FPI-2119, shows strong activity against some of the most dangerous drug-resista...

Fedora Pharmaceuticals is presenting new preclinical data at the IMARI conference demonstrating that its lead candidate, FPI-2119, shows strong activity against some of the most dangerous drug-resistant Gram-negative infections, supporting its advancement toward clinical trials. #IDsky #Medsky

ONE ANTIBIOTIC PK TABLE TO RULE THEM ALL

Absorption takes drug into blood from GI,
Vd spreads drug out to where bug calls home.
And after bacteria are doomed to die,
The drug’s eliminated on the porcelain throne

In the Land of Notion where this table doth lie…

#idSky #microsky #pharmsky #medsky

Goodbye 2025, hello 2026!🦠 As the year comes to a close, here's all of the incredible microbes that were discovered this year and featured as our Microbe of the Month. We're so glad to see you all enjoying this series as much as we do, and we hope you're as excited to see what 2026 has in store🔬🔎

Oral vancomycin use and incidence of vancomycin-resistant enterococci: time-series analysis - PubMed There was a significant association between institutional oral vancomycin use and hospital-acquired VRE incidence, highlighting the need for antibiotic stewardship for oral vancomycin use to contain the nosocomial spread of VRE in addition to infection control measures.

pubmed.ncbi.nlm.nih.gov/39617941/

www.mendeley.com/catalogue/2c...

pubmed.ncbi.nlm.nih.gov/33441409/

pubmed.ncbi.nlm.nih.gov/40601321/

I'm sure some confounding in this retrospective study. But more evidence that gentamicin probably isn't doing anything in Staph PVE.
Rifampin still an open question

#IDSky

The real edge is decreased recurrence. That itself is important and financially shown to be cost effective. But fidaxo is also narrower spectrum compared to vanc, and doesn't promote resistance (especially VRE). Finally the sporicidal effect might be useful in reducing transmission in outbreaks.

TAPER-V's primary outcome was standard vs tapered vanc. Comparisons with fidaxo were from other studies on fidaxo, not TAPER-V.

In comparison to what, im ceftriaxone? If so, reasons include higher resistance compared to ceftriaxone, penetration to relevant sites (especially rectal/throat) and most importantly, clinical failure rates.

COVID-19 mRNA Vaccination and 4-Year All-Cause Mortality Among Adults in France This cohort study uses the data from all adults aged 18 to 59 years living in France on November 1, 2021, to evaluate whether there is an association of receipt of an mRNA COVID-19 vaccine with long-t...

• Vaccinated people had lower risk of death from any cause.
In short: mRNA vaccines weren’t just safe — they were protective across the board. 🔥📉 shorturl.at/GcZeK #EMSky

30% mortality in E. faecalis endocarditis persists. Ceftobiprole showed better activity vs borderline-PRASEF & VREfs than ampicillin-ceftriaxone in 78 isolates. Combo helps some.⚡🦠

#idsky

👉 Evidence is limited, but reducing β-lactam doses too early in AKI may underdose critically ill patients at the worst possible time.
🛡️ Delayed dose reduction (after reassessing kidney recovery ~48H) might improve mortality—but better prospective studies are urgently needed #idsky #EMIMCC

Beta-lactam dose reductions in critically ill patients with acute kidney injury: a scoping review - Critical Care Background Acute kidney injury is a common complication in critically ill patients, often coinciding with the need for antibiotic therapy. The dose of beta-lactam antibiotics is frequently adjusted an...

⚡💉Are We Jumping the Gun? Early Beta-Lactam Dose Cuts Risk Underdosing in AKI, Critical Care, 2025

link.springer.com/article/10.1...

Link to X post:
x.com/ABsteward/st...
#idsky #EMIMCC

This year’s US ID Fellowship Match saw 272 adult ID and 44 pediatric ID matches - but overall fewer physicians are entering the field and over half of fellowship programs went unfilled.
www.idsociety.org/news--public...

Breaking down the Desirability of Outcome Ranking (DOOR): unpacking the methodology behind the Dalbavancin as an Option for Treatment of Staphylococcus aureus Bacteremia (DOTS) trial Desirability of Outcome Ranking (DOOR) outcomes such as the primary outcome of the DOTS (Dalbavancin as an Option for Treatment of Staphylococcus aure…

🤔 I’ll admit — I’m still wrapping my head around DOOR in clinical trials. I’m used to P-values and classic non-inferiority, but DOOR feels different.
Breaking down the DOOR in DOTS RCT @cmicomms.bsky.social
#idsky #EMIMCC
www.sciencedirect.com/science/arti...

consensus.app/papers/tuber...

consensus.app/papers/adver...

consensus.app/papers/adjuv...

consensus.app/papers/adjuv...

consensus.app/papers/antim...

consensus.app/papers/body-...

consensus.app/papers/psych...

Closest point between Russia-USA= 2.5 miles (Diomedes Islands). Closest point between Europe- USA= 2500 miles (Maine-Ireland).

Why does he keep bringing up Trump's acceptance of vaccine safety as a qualifying argument. Does it matter what someone not qualified to judge vaccine safety says about vaccine safety?

CRISPR-Cas?associated SCCmec variants in methicillin-resistant Staphylococcus aureus evade rapid diagnostic detection

✅ Just Accepted
🔗 https://bit.ly/3LWRti0

Triazoles versus Echinocandins for the first-line treatment of invasive pulmonary aspergillosis ? A propensity score weighted multicenter study

✅ Just Accepted
🔗 https://bit.ly/3LV7LYP

A screen shot of the antibiotic personality quiz

It’s World AMR Awareness Week, and this year I had the honor to re-imagine and doodle the antibiotics in the antibiotic personality quiz 😇🖍️
Thank u @brxad.bsky.social for this amazing and fun opportunity!

C’mon, take the quiz, it’s a #WAAW tradition 😉💊
#IDSky

quiz.tryinteract.com#/59e68e3a8ec...

Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates - Nature Communications Ghatbale et al. adapted a co-evolutionary technique to develop Klebsiella pneumoniae phages to be highly active longitudinally against K. pneumoniae clinical isolates, including drug resistant isolate...

Phages!

Authors identified phages w/ lytic capacity against a few clinical isolates, & through experimental evolution were able to vastly expand the host ranges to kill a broader range of clinical K. PNA isolates including MDR (multi-drug resistant) and XDR. #IDSky

www.nature.com/articles/s41...

Meningococcal urethritis prevalence in Ohio men is 1.5% (0.8-2.5%) via PCR. Symptomatic cases confirmed 100% vs. 9.1% in random. One case per 4-11 men with gonorrhea. 🦠🔬

#idsky

How Rwanda mounted a research response with an investigational vaccine just ten days into a Marburg outbreak - npj Vaccines npj Vaccines - How Rwanda mounted a research response with an investigational vaccine just ten days into a Marburg outbreak

An investigational Marburg vaccine used in Rwanda’s 2024 outbreak is not yet approved but can be deployed in outbreaks if protocols move quickly

A monoclonal antibody was also used in Rwanda, but this isn’t a cure. Past Marburg outbreaks have had 24–88% fatality rates, esp affecting health workers

Ethiopia confirms first outbreak of Marburg virus disease Ethiopia’s Ministry of Health has confirmed an outbreak of Marburg virus disease in the South Ethiopia Region, the first of its kind in the country, following laboratory testing of samples from a clus...

www.afro.who.int/countries/et...

Post Treatment Blood Cultures in Patients with Infective Endocarditis: Valuable, Inconsequential or Worse?

✅ Just Accepted
🔗 doi.org/10.1093/cid/ciaf618

Dr. Julie Ann Justo is joined by experts Drs. Krista Gens and Javier A. Villafuerte Gálvez as they dive deep into the gut microbiome to explore the latest therapeutic frontier for C. difficile infections. This podcast was supported by an unrestricted grant from Nestlé Health Science sidp.pinecast.co