An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somitogenesis IMP dehydrogenase (IMPDH) controls a key regulatory node in purine biosynthesis. Gain-of-function mutations in human IMPDH2 are associated with neurodevelopmental disorders and neuromuscular symptoms ...

New preprint from the Kollman/Wills collab! My colleague Audrey O'Neill and friends demonstrate the effects of an IMPDH2 mutant associated with neurodevelopmental disorders on development using a Xenopus model. Beautiful electron and light microscopy included!

www.biorxiv.org/content/10.1...

Deaths from heart disease down 75%, that’s NIH.

Deaths from stroke down 75%, that’s NIH.

HIV/AIDS no longer a death sentence, that’s NIH.

99% of FDA approved drugs in the last decade, that’s NIH.

Please show this video to anyone who doesn’t understand why the NIH is so important.

2023: mRNA vaccine scientists win the Nobel Prize

2025: US government cuts research on mRNA vaccines

Ardem, I am sorry. In this middle of this chaos, HHMI will always hold the dubious distinction of being the first organization, federal or private, to cut an ongoing and funded DEI program. In the darkest hour, it ran for the hills. As a member of those groups, I can’t tell you how painful this is.

Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference A critical step in infections is the attachment of many microorganisms to host cells using lectins that bind surface glycans, making lectins promising antimicrobial targets. Upon binding mannosylated ...

New Kollman lab preprint featuring some challenging cryo-EM by my colleague Kelli Hvorecny, in collaboration with the Klevit and Sokurenko labs: www.biorxiv.org/content/10.1...

#cryoEM #cryo-EM #microbiology #immunology