RESEARCH | PX Chen, Y Tian et al. (CAS)

Mitochondrial superoxide production preserves nuclear envelope integrity by controlling lipid peroxidation, with impact on ageing in C. elegans 🧪

👩‍🔬 Today is International Day of Women and Girls in Science! Meet Dunja Petrovic, postdoctoral researcher in the group of
@thevilchezlab.bsky.social at the @unicologne.bsky.social

Great collaborative effort by:
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu
@cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social

The review covers proteostasis mechanisms across major organelles, including:
• Nucleus
• Mitochondria
• Endoplasmic reticulum
• Golgi apparatus
• Lysosomes

We also highlight proteostasis in membraneless organelles, such as:
• Stress granules
• Processing bodies
• Nucleolus
• Nuclear speckles

FEBS Press Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the n....

Our new review on proteostasis of organelles in aging & disease is now online in The FEBS Journal!
We discuss recent insights on how #proteostasis safeguards organelle integrity and function across the cell in #aging and disease
doi.org/10.1111/febs...

FEBS Press Cover illustration Stress granules in iPSCs treated with arsenite (G3BP1 (green) / NUP107 (red) / Hoechst (nucleus)). Image credit: Saygin Bilican. The image refers to Bilican et al., “C9orf72 ALS-ca....

Saygin’s new ALS paper — showing nucleoporin alterations — just made the journal front cover @febsletters.bsky.social febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com/doi/10.1002/...

🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉

A host organelle integrates stolen chloroplasts for animal photosynthesis Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.

www.cell.com/cell/abstrac...

A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis

Fluoreszenzfärbung von Neuronen unter einem Mikroskop mit grünen und blauen Markierungen auf dunklem Hintergrund.

🧓Wie das Altern neurodegenerative Krankheiten treibt 🧠

@thevilchezlab.bsky.social @cecad.bsky.social hat einen direkten molekularen Zusammenhang zwischen Altern und neurodegenerativen Krankheiten identifiziert.

flourescent picture of motor neurons dyed green and blue (nucleus).

🧓How aging drives neurodegenerative diseases🧠
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.

A titanic effort from Seda and the lab in collaboration with Nuria Flames’ lab ‪@sedakoyuncu.bsky.social‬ @unicologne.bsky.social‬ @cecad.bsky.social‬ ‪@ibv-csic.bsky.social‬ ‪@nataging.nature.com‬‬‬‬‬‬

We also discovered that the deubiquitinase USP4 leads to EPS8 accumulation during aging.
Reducing USP4 prevented EPS8 accumulation, extended lifespan, and lessened disease effects.
👉 Targeting EPS8/USP4 could open new therapeutic strategies for neurodegeneration.

In C. elegans & human cells, we found that age-related EPS8/RAC signaling hyperactivation promotes pathological aggregation of fifferent proteins (polyQ, FUS, TDP-43).
Decreasing EPS8 (or tuning RAC signaling) prevents aggregation & and neurodegeneration.

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...

FEBS Press Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

Shuttle and stabilize: H1.2-FUS complex in amyotrophic... : Neural Regeneration Research An abstract is unavailable. This article is available as a PDF only.

Shuttle and stabilize: H1.2-FUS complex in amyotrophic lateral sclerosis pathogenesis
journals.lww.com/nrronline/ci...

I was just wondering the same thing, given the number of recent papers along these lines

A multichaperone condensate enhances protein folding in the endoplasmic reticulum - Nature Cell Biology Leder et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins.

💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social
bit.ly/47b3Mjk

Franziska Hommen did an excellent job in her thesis defense — we have a new PhD in the building! @cecad.bsky.social @cga-age.bsky.social

Vilchez Lab Curious to see what we do? Check out our research summary video:  https://youtu.be/kalsrf1ZbQ0

Hi Dani, I would really appreciate it if you can add me to the Science feed:
www.davidvilchezlab.com
scholar.google.com/citations?us...

Learning a lot and having fun at the #OpenDay #Science @cecad.bsky.social @mpiage.bsky.social

The project will be carried out at the CECAD Research Center (University of Cologne): @unicologne.bsky.social @uniklinikkoeln.bsky.social @cecad.bsky.social

Postdoc Position (f/m/x) We are looking to support our rapidly growing team as soon as possible:

We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...

🤪🤪🤪🤪🤪🤪🤪🤪🤪

Felicidades!

C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 C. elegans’ TEI of learned pathogen avoidance is induced by a third bacterial small RNA, Pfs1, from P. fluorescens 15.

🧪#Celegans - I am very excited to announce the publication of our latest finding in transgenerational epigenetic inheritance (TEI) of learned pathogen avoidance - • C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 www.science.org/doi/10.1126/...

Thanks Barak😉

The study is part of the CRC1678 consortium;) @crc1678.bsky.social

Online now - a tribute to the memory of Prof. Joan J. Guinovart from Jordi Duran and Matthew Gentry.

Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science.

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New work from our lab;)