Getting the ol' grad school gang back together with Carafe2 -- Bo Wen (@maccoss.bsky.social and Bill Noble) and @jspaezp.bsky.social (@willfondrie.com at @talusbio.bsky.social) teamed up for essentially some late night hackathons to build out Carafe for @brukercorporation.bsky.social timsTOF data.

I 100% agree with this take.

Plug: If you are working with #proteomics and/or #massspec data, check out our shortcourse at #ASMS2026 to get a jump start on many of these methods! (Course 04 here: www.asms.org/conferences/...)

GitHub - PRIDE-Archive/pyprideap: pyprideap is a library to handle affinity proteomics files from PRIDE database; including reading; parsing validating and other algorithms pyprideap is a library to handle affinity proteomics files from PRIDE database; including reading; parsing validating and other algorithms - PRIDE-Archive/pyprideap

🚀 Introducing pyprideap — one unified Python API for #SomaScan & #Olink QC and analysis (finally!). Normalisation, LOD, DE, interactive HTML reports. Open source and community-oriented as part of the
@pride-ebi.bsky.social Affinity Archive.

github.com/PRIDE-Archiv...
#Proteomics #OpenScience.

Was it the jacket that made it happen?

Saw a post about GPU depreciation and I could hardly believe what second-hand H100s were selling for. The GPU market is wild.

Best St. Louis BBQ - Salt + Smoke BBQ St. Louis BBQ that will make your mouth water. We’re known for the good stuff. The meat stuff. The melt-in-your-mouth and fall-off-the-bone stuff. We’re Salt + Smoke and we know how to BBQ real good f...

Landed in St Louis for #USHUPO2026 and grabbed some BBQ 😋

2 things:

1. Salt + Smoke (www.saltandsmokebbq.com) is delicious. ⭐️ ⭐️ ⭐️ ⭐️ ⭐️

2. I’m once again reminded that Seattle doesn’t know what to do with a smoker 😔

There's an art to representing MS-based bioinformatics, and these authors have done an amazing job.

This is a work I’ve been following. Some cool ideas here - definitely check it out!

Yep, Ben @proteomicsnews.bsky.social and I finally got Bill Noble on #THEProteomicsShow. We had been wanting him on forever so he went and won an award to make it easier for us to meet. Enjoy the rambles (I hope), and mind the monkeys. Find it wherever you find fine podcasts.

I love that @obsidian.md requires you to type the key sequence to exit vim before enabling vim key bindings 😆

Nice work! I’m curious how it compares to Triqler, which is conceptually similar 🤔

This one is good read!

I am hiring a staff bioinformatician for my new lab at the University of Utah! Please consider applying if you are on the hunt:
employment.utah.edu/salt-lake-ci...

Nerf guns + eye protection for the family (including us, the parents) were a huge hit.

So many smiles and laughs have been shared in our epic battles for the basement today 😊

Perspectives in computational mass spectrometry: recent developments and key challenges Abstract. Summary: Mass spectrometry (MS) is a cornerstone technology in modern molecular biology, powering diverse applications across proteomics, metabol

Perspectives in computational mass spectrometry: recent developments and key challenges #BioinformAdv academic.oup.com/bioinformati...

Data Science Intern - Seattle, WA Talus Bioscience is seeking highly motivated summer interns to join our team! These paid summer internships provide opportunities to own and participate in challenging and impactful business-critical ...

Looking for an internship next summer? Join my team @talusbio.bsky.social!

Apply 👇 by Jan 31 🤖🧬💻
www.applicantpro.com/openings/tal...

Wednesday is typically one of my WFH deep work days 💻🧬🤖

Will's GitHub wrapped

Ha. Good to know I still get to code a bit 😀

git-wrapped.com

Progress Update: Sep-Nov 2025 Regulome profiling, new paths to the androgen receptor, and oncogenic fusion proteins

A nice write up of what we’ve been working on recently @talusbio.bsky.social by @afederation.bsky.social.

Check it out to get a glimpse of our progress drugging AR and success from our lab-in-the-loop active learning cycles.

And don’t forget to subscribe for more 👇

blog.talus.bio/p/progress-u...

😳 ... it was me. I'm part of the problem. Forgot about this PR github.com/lazear/sage/...

Who in the training data used so many emojis in their code?

Fwiw chemistry is often called the bottleneck for platform biotech co's because the main affordable places to get chemistry done are WuXi and Enamine, and it takes 2-3 months to get compounds back from them. 2-3 month is a looong wait in startup time. Other places are more/too expensive.

Open faculty position (Assistant or Associate) in UW Medical Genetics. As you might expect, faculty often end up also interacting with Genome Sciences, so we're hoping for some great prospects! Note the clinical requirements for the position. apply.interfolio.com/176466

My first @umasschan.bsky.social/@impvienna.bsky.social affiliated paper is up!

tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs.

Check it out!

academic.oup.com/bioinformati...

Affinity has a cleaner UI and some tools that are missing in Inkscape.

The suite also has a Photoshop and InDesign replacements - I’ve used the later for my scientific posters for awhile now

Affinity has been my favorite design software for awhile now. Now that its free is even better!

Getting started with everyone's favourite framework just got easier ✨

Upcoming talks at Human Proteome Organization! Come check out what Talus Bio has been working on over the last year, from mapping the regulome to manipulating it and modeling it, all using mass spectrometry proteomics as a driving force.

GitHub - wfondrie/genzolars: polars but make it bussin fr fr no cap polars but make it bussin fr fr no cap. Contribute to wfondrie/genzolars development by creating an account on GitHub.

In case anyone, like me, needed a Python version: github.com/wfondrie/gen...

I couldn't help it. Now for polars in #python 🐍🐻‍❄️
github.com/wfondrie/gen...