Right before the holidays, happy to share our new preprint 🌲 The 3rd main part of my PhD, from a simple idea long before the spatial era boom: how do tissues from different regions of the same tumor differ in immune cell states and TCR clonality?
Thanks to all co-authors for their work and support!

The T cell subsetting challenge Exploiting specific T cell subset properties bears potential for T cell therapies but is complicated by inconsistencies in T cell subset definitions and markers. Here, we discuss causes for the definition and classification complexities to provide a handle for how to navigate the T cell subset jungle.

The T cell subsetting challenge #immunology

So happy to be back in beautiful Lisbon for #EACR2025!
Looking forward to the fantastic scientific talks ahead, and to discussing our study on the spatial organization of intratumour immune heterogeneity (poster P-755 tomorrow!)🪻

📍 8th Course on Computational Systems Biology of Cancer
“Multimodal data analysis and network modelling to master cancer hallmarks” at Institut Curie.

➡️ Registration open until June 15: training.institut-curie.org/courses/csbc...

We are thrilled to support these outstanding scholars! Congratulations, @juliemmazet.bsky.social, @christinamt.bsky.social, and @marthamz.bsky.social! 🎉

Happy to share that I have been awarded the EACR-Mark Foundation Postdoctoral Fellowship! This funding supports my project on identifying TME signals shaping distinct CD8 T cell states at @danielathommen.bsky.social @nkinl.bsky.social.
Grateful for this opportunity!
Congrats to all the recipients!

Thank you Marianne :)

Continuous replenishment of the dysfunctional CD8 T cell axis is associated with response to chemoimmunotherapy in advanced breast cancer Chemotherapy combined with immune checkpoint blockade has shown clinical activity in breast cancer. Response, however, occurs in only a low proportion…

Excited to share my first post & see the second part of my PhD work published! Our study on mTNBC highlights that baseline clonal expansion of dysfunctional CD8 cells is linked to better response to chemoimmunotherapy.
More here: www.sciencedirect.com/science/arti...

#CD8 #TCellExhaustion #TNBC