#Medsky🧪 #oncosky #Immunosky #publichealth these studies demonstrate that #Tcell mitochondrial health is tightly linked to immune fitness and that active aldehydes derived from metabolic dysfunction in the tumor microenvironment damage mitochondria and drive #Tcellexhaustion.

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - Nature Immunology One of three back-to-back papers to show dosage of BACH2 can modulate T cell differentiation and function and how we might apply this to enhance chimeric antigen receptor T cell therapies for cancer.

Amazing study from @RoychoudhuriLab highlighting the next-gen genetic manipulation to tweak the right amount of protein expression to enhance T cell function in cancers. Kudos to the authors.
Check it out : www.nature.com/articles/s41...

#tcellexhaustion #tcells

We’re loving being back on the mic!

@theresisters.bsky.social have had convos with guests of all stripes, and this one with Anthony Leonardi does not disappoint!

What a fascinating - and very kind - human he seems to be.

#TCellExhaustion
#MakeYourNoise
#ArtsAndScience
#GoodHumaning

Frontiers | Immunodiagnosis — the promise of personalized immunotherapy Immunotherapy showed remarkable efficacy in several cancer types. However, the majority of patients do not benefit from immunotherapy. Evaluating tumor heter...

#COVID are characterized by #Tcellexhaustion, which impairs immune surveillance & ⏫️ susceptibility to infections & adverse events such as myocardial infarctions, septic shock & ARDS

www.frontiersin.org/journals/imm...

www.frontiersin.org/journals/imm...

www.sciencedirect.com/science/arti...

#Medsky🧪 #IDsky #immunosky #Publichealth
#Tcellexhaustion (a terminal state of immune dysfunction characterized by impaired proliferation & effector functions, diminished cytokine secretion & sustained expression of inhibitory receptors) .

Epigenetic regulation of T cell exhaustion in cancer - Nature Reviews Cancer Transcriptional and epigenetic mechanisms governing T cell exhaustion substantially impact immunotherapy effectiveness. In this Review, Kang et al. outline epigenetic regulatory programmes that i...

Epigenetics Review - Epigenetic regulation of T cell exhaustion in cancer go.nature.com/4ohBOrZ

Ben Youngblood (St. Jude Children's Research Hospital) reporting in Nat Rev Cancer

#Epigenetics #Review #TCellExhaustion #Cancer
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High-resolution insights without cell sorting; epigenometech.com

LinkedIn This link will take you to a page that’s not on LinkedIn

Honored to share our latest paper on T-Cell Exhaustion's role in Post-Acute Infection Syndromes, now features YouTube!
Watch here: www.youtube.com/watch?v=WSNV...
#Immunology #TCellExhaustion #LongCOVID #ImmuneDysfunction #MedicalResearch #HealthcareInnovation #Qeios

The $20 Cure That Terrifies Big Pharma I Solved Cancer, Neuroinflammation, and Mitochondrial Dysfunction. Here’s the math, and the proof. Real data. Real images. Real results.

Disulfide stress → disulfidptosis in CD8+ T cells? Big!

We explored similar redox targets in our recent Substack - cystine import, GSH, ferroptosis, and how to collapse tumor defense for <$20.

atorchbearer.substack.com/p/the-20-can...

Curious to hear from you!
#CancerCure #TCellExhaustion #Tumor

New research links #MECFS to T cell exhaustion—immune cells worn out from chronic activation. This isn’t “just fatigue,” it’s a biological crisis. We need urgent investment in ME/CFS research and real answers for millions suffering. #pwME #TcellExhaustion #ScienceMatters

Continuous replenishment of the dysfunctional CD8 T cell axis is associated with response to chemoimmunotherapy in advanced breast cancer Chemotherapy combined with immune checkpoint blockade has shown clinical activity in breast cancer. Response, however, occurs in only a low proportion…

Excited to share my first post & see the second part of my PhD work published! Our study on mTNBC highlights that baseline clonal expansion of dysfunctional CD8 cells is linked to better response to chemoimmunotherapy.
More here: www.sciencedirect.com/science/arti...

#CD8 #TCellExhaustion #TNBC

I read the med journal on T-Cell exhaustion. Then, these two trailblazers who research and treat make the time to produce a podcast. Thank you. #ChronicIllness #Immunology #Virology #Microbiology #Neuroscience #TCellExhaustion #Autoimmune

#MedSky🧪 #IDSky #Immunosky #publichealth Very interesting study Persistent antigen stimulation, as in cancer and chronic
infections, results in #Tcellexhaustion (TEX) a state of
impaired effector functions.