Finally published. Many thanks to a wonderful collaborative team and scientific platforms!!! And thanks to editors and reviewers for enthusiasm and a great review.
www.nature.com/articles/s41...
I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...
My main postdoc paper is now out in @natureportfolio.nature.com npj Antimicrobials and Resistance! www.nature.com/articles/s44.... Using flow cytometry, we show that the nucleoside analogues azidothymidine, didanosine, stavudine, and trifluridine reduced transfer of AMR plasmids pCT and pKpQIL (1/3)
And the preprint is out! www.biorxiv.org/content/10.6...
We compared plasmid conjugation in liquid and on solid across 13 AMR plasmids with different types of conjugative pili.
Here is it! Super new science from us on horizontal gene transfer & bact defense systems! Liyana OW YONG discovered the first-of-its-kind defense factor AbjA that triggers 'abortive conjugation' as a defense mechanism, by targeting the T4SS! How neat?! #MicroSky 1/7
www.biorxiv.org/content/10.6...
Are you investigating the biology of prokaryotic or eukaryotic cells? Are you looking for an excellent scientific environment to establish and lead your own research team? The I2BC is your place and a new call for team leaders is now open.
More info👇Deadline 22nd April
@i2bcparissaclay.bsky.social
#MicroSky Please RT
@erc.europa.eu-funded postdoc position in my lab to identify the molecular basis of prey-predator interactions using our favorite micro-vampire Bdellovibrio exovorus as a model.
Let's find what the bite is made of! 🧛
Flexible start date.
Info: euraxess.ec.europa.eu/jobs/415877
This is the first time we observed bacteria use plasmolysis to defence against phages! biorxiv.org/content/10.6...
Thanks all the authors to discover this together! @fnobrega.bsky.social Zhiying @garushyants.bsky.social Dinshaw and Eugene
🎉 We are thrilled to share our latest study revealing a new mechanism by which Legionella pneumophila evades antibiotic killing via reversible genetic variation mediated by integrative and conjugative elements (ICEs).
📖 Here for the full story:
www.biorxiv.org/content/10.6...
New preprint out on bioRxiv!
www.biorxiv.org/content/10.6...
Can conjugative plasmids be used to control plasmid and pathogen spread?
Follow me down the rabbit hole that led to this story 🧵
💡 We are inviting you to nominate a woman in microbiology whose work or impact deserves to be seen.
Selected nominations will be featured on the FEMS website and across our social media channels on International Women’s Day, 8 March.
👉 Who inspires you? Nominate them by 4 March . buff.ly/AKyMbQD
Happy to share a new review proposing a unified nomenclature for T4SSs.
Great collaboration with Peter J Christie, Gabriel Waksman, Ronnie Per-Arne Berntsson and our team.
academic.oup.com/femsre/artic...
#T4SS#Microbiology
Ingénieur-e d'étude en biochimie des protéines en concours externes INRAE.
Si vous êtes passionnés par les biochimie des protéines et souhaitez rejoindre un environnement dynamique, n'hésitez pas à postuler (Clôture des inscriptions : 19 Mars)
jobs.inrae.fr/concours/con...
Un poste de MCF (👇) s'ouvre dans notre unité MMSB, avec possibilité d'accueil dans mon équipe
Venez travailler avec nous sur les mécanismes moléculaires impliqués dans la réponse au stress et la modulation de la croissance chez les bactéries!
N'hésitez pas à me contacter si vous êtes intéressés!
📢 Recrutement d’un(e) Maître(sses) de conférence en Biochimie générale, spécialité bactériologie moléculaire à MMSB
🔬Recherche
*Immunité anti-phages
*Réponse au stress, modulation de la croissance bactérienne
✉️ christophe.grangeasse@cnrs.fr
📚Enseignement : Université Lyon I
✉️ patrice.gouet@ibcp.fr
Un poste de Maître de Conférence est ouvert pour rejoindre notre unité à Lyon !
Possibilité de rejoindre mon équipe pour travailler sur:
- caractérisation des mécanismes de défense anti-phage
- transfert horizontal et interactions entre éléments génétiques mobiles
N'hésitez pas à me contacter
Great new story from Sophie Helaine and Molly Sargen!
www.helainelab.com
Big week: welcomed a new baby boy Harris Lopatkin, AND our PlasAnn paper is finally out: academic.oup.com/nar/article/... (obviously the first more important than the second 🥰). Currently on leave but if anyone has the need to annotate large plasmids, go check it out!
New paper out in @pnas.org, and it made the cover! 👁️
We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve.
‼️Check Paula’s 🧵 and the paper👇
𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿
www.pnas.org/doi/10.1073/...
New publication from the Lesterlin (TacC) team at MMSB! Congratulations to all authors. In collaboration with Pierre Bogaerts (UCL Belgium) and J. Villa (UB Barcelona)
doi.org/10.1093/nar/...
#microsky
Massive update of preprint with @polardlab.bsky.social!
Bacteria have evolved two systems to recombine extracellular DNA
www.biorxiv.org/content/10.1...
Kudos to lead authors Léo Hardy, Violette Morales and Clothilde Rousseau, and to outstanding Dalia's lab and @epcrocha.bsky.social
🧵⬇️
🚨L'ENS de Lyon recrute un.e maître de conférence qui rejoindra le CIRI pour développer ses recherches sur l'immunité bactérienne, les transferts horizontaux et les MGE.
📖 Une très belle opportunité d'enseigner à des étudiants brillants tout en menant des recherches excitantes !
Bacteria chromosomes contain Genomic Islands that provide virulence, antibiotic resistance, MGE-defence,... They transfer between cells, but the mechanism of most remains elusive.
Here we explore the conjugative capacity of these mysterious Genomic Islands.
www.biorxiv.org/content/10.6...
My team at @cbitoulouse.bsky.social is recruiting a postdoc #bioinformatics with solid experience in metagenomic analyses.
Interest in evolution, ecology & MGEs is important.
The offer stands until the perfect candidate is found, and it could be you 🫵
🔁 🙏
#microSky #phagesky #UTIsky
@cnrs.fr
Neisseria gonorrhoeae carries an unusually large number of restriction–modification systems (up to 16!), many of which are phase-variable. How does this affect plasmid transmission in gonococci? doi.org/10.64898/202...
Une opportunité unique de former des étudiants talentueux à la biologie des bactéries à l'ENS Lyon et mener des recherches sur les phages, l'immunité bactérienne, le transfert génétique horizontal (HGT) et/ou les éléments génétiques mobiles au sein du département de bactériologie du CIRI.
📢 Recruitment of an Associate Professor (Maître de conférences) in Bacteriology at CIRI and ENS de Lyon.
Research at @ciri-lyon.bsky.social @francoisrousset.bsky.social
@labxc.bsky.social
Anti-phage Immunity, Horizontal gene/ MGE transfer
📚 Teaching at ENS de Lyon within the Department of Biology.
