BARI is celebrating Orion Weiner on his new review! It dives into how immune cells and tiny amoebas both build their own chemical signposts to team up from far away. Two very different cells solving the same puzzle in clever ways. cshperspectives.cshlp.org/content/earl...

Transcriptional Regulatory Modulation as a Potential Therapeutic Modality Numerous human diseases are caused by changes in gene expression levels. In addition, changing the expression levels of specific genes can lead to therapeutic benefits for several diseases. Systems us...

Big cheers for BARI’s Nadav Ahituv on this new review! It dives into clever ways scientists can dial gene activity up or down, like a smart dimmer switch, to help treat genetic conditions without rewriting the DNA code. Promising for the future of medicine! www.annualreviews.org/content/jour...

Congrats to BARI’s Tien Peng on his new paper! It shows how aging fibroblasts in the lung starts a chain reaction of chronic inflammation and overactive immune cells, helping us understand why older folks are more at risk for serious lung issues. Hopeful step toward better aging!

NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells Aging is accompanied by significant changes to the immune system. Allen et al. demonstrate that age-related NF-κB activation in fibroblasts remodels the lung resident immune system and promotes the em...

www.cell.com/immunity/ful...

Lysosomal salvage of neuronal lipids enables glial infiltration of synaptic regions Brain development relies on coordinated remodeling of neuronal and glial membranes. Theisen et al. show that lysosomal breakdown of lipids sculpts brain architecture, as glia phagocytose neuronal memb...

BARI is celebrating John Vaughen’s new Neuron study! It shows developing glia phagocytose neuronal membranes, salvage the lipids in lysosomes, and turn them into CPE lipids needed for autophagy and synaptic ramification. Fantastic work! www.cell.com/neuron/fullt...

BARI is celebrating Yin Shen’s new Nature Comms study! It shows how the brain cleverly compensates when enhancers are deleted on one SIN3A allele by boosting the other, precise dosage control that could matter a lot for healthy brain aging. www.nature.com/articles/s41...

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

1st McKinley Lab grad student’s 1st preprint!
@claireang.bsky.social studied how the uterus safely excises massive amounts of tissue during menstruation and pregnancy.

Come for her GORGEOUS images, stay for her incredible discoveries.
www.biorxiv.org/content/10.6...
w/ @akelleher1017.bsky.social

First gila monsters, now pythons - reptiles are proving to be surprisingly influential players in the obesity pharmacotherapy field...

🧠📈🦎🐍

Magnetic Resonance Imaging Abnormalities and Incidental Age-Related Changes In this issue of JAMA Internal Medicine, the Finnish Imaging of Shoulder Study (FIMAGE) study1 offers timely and clinically important evidence regarding what clinicians and patients read in shoulder m...

Big congrats to BARI's Dr. Brian Feeley on his JAMA Internal Medicine article! It breaks down how most shoulder MRI "issues" are just normal aging wear-and-tear, even in pain-free folks—super relevant to aging biology for smarter care and avoiding extra surgeries. jamanetwork.com/journals/jam...

Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer Montoya et al. uncover a role for alanine as a conserved metabolic substrate for MYC-driven liver cancer. GPT2 is a therapeutic target for MYC-overexpressing liver tumors.

Really excited to present the latest publication from our lab.

Outstanding work by Ton Montoya who really conceptualized and led this project. He finds that MYC-driven liver cancer uses alanine as a fuel. Implications for new treatments for #HCC 🧪

@ctbatucsf.bsky.social @ucsfcancer.bsky.social

Big cheers for BARI's Dr. Diane Barber on her Acta Physiologica review about lysosome pH in health & disease! It connects the dots on how pH shifts affect lysosomal roles: super relevant to aging, where off-balance pH worsens neurodegeneration and protein buildup. Exciting therapeutic angles!

BARI's Peggy Cawthon at the ICFSR conference on healthy longevity & aging biomarkers: Hosted by Nature Aging's Sébastien Thuault, with Luigi Ferrucci, David Furman, & Dan Belsky.

Big cheers for BARI member Isha Jain on her new Cell paper! It reveals how vitamins B2 and B3 can treat NAXD disease, saving metabolism, shielding the brain, and stretching lifespan over 40x in models. Ties right into aging biology, where boosting NAD could slow down age-related breakdowns.

Congratulations @kelseyhcollins.bsky.social !! So proud of your accomplishments🏆🤩

Non-visual light modulates behavioral memory and gene expression in Caenorhabditis elegans Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenet...

BARI’s Dengke Ma shows non-visual light tweaks genes & improves adaptability in worms in a bacteria-dependent, wavelength-sensitive pathway. Enhances olfactory memory & potential for aging sensory research. Check it out: elifesciences.org/articles/108...

Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude High-altitude conditions improve glucose tolerance and reduce diabetes risk, but the physiological mechanism is not well understood. Using mouse model…

Isha Jain at BARI just published this in Cell Metabolism: Living high up makes blood sugar drop because red blood cells soak up glucose in low oxygen. Hypoxia can even treat diabetes in mice! #metabolism www.sciencedirect.com/science/arti...

Therapeutic targeting of neuroimmune mechanisms in neurodegeneration - Nature Reviews Drug Discovery Neuroimmune interactions shape neurodegenerative disease progression. This Review examines how microglia integrate signals from central and peripheral immune cells, outlines emerging therapeutic targe...

BARI’s Andrew Yang breaks down how immune cells in the brain fuel neurodegeneration and what we can target to stop it. From microglial states to complement and inflammasomes, this review maps therapies that could help aging brains stay sharp longer. go.nature.com/4096fGg
#aging #neuroscience

Modulation of the 14-3-3σ/C-RAF "Auto"inhibited Complex by Molecular Glues - PubMed Molecular glues, compounds that bind cooperatively at protein-protein interfaces (PPIs), are revolutionizing chemical biology and drug discovery, allowing the modulation of traditional "undruggable" targets. Here, we focus on a native regulatory PPI between the scaffolding protein 14-3-3 and C-RAF, …

pubmed.ncbi.nlm.nih.gov/41617210/

BARI’s Andrew Yang unpacks how hypertension quietly injures the brain via AngII long before pressure rises. Early hits to endothelial cells, oligodendrocyte precursors, and inhibitor neurons, all independent of blood pressure. Strong implications for better dementia prevention strategies.

Exploring the Association between Epigenetic Age and Intensive Care Unit Delirium: A Pilot Feasibility Study Abstract. Epigenetic clocks (EC) measuring epigenetic age (EA) and epigenetic age acceleration (EAA) are biomarkers of biological aging, but their associat

John Newman at BARI looks at ICU delirium and epigenetic clocks: Feasible from serum, with Elastic Net acceleration linked to lower severity scores (day 8 and at discharge). A noteworthy finding on biological aging in acute illness. academic.oup.com/biomedgeront...

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

BARI spotlight: Dr. Martin Kampmann leads Cell study using CRISPR in iPSC neurons to decode tau handling, spotting ways to block toxic buildup in age-related diseases like Alzheimer’s. Read the article here: www.cell.com/cell/fulltex...

Ageing promotes microglial accumulation of slow-degrading synaptic proteins - PubMed Neurodegenerative diseases affect 1 in 12 people globally and remain incurable. Central to their pathogenesis is a loss of neuronal protein maintenance and the accumulation of protein aggregates with ageing^1,2. Here we engineered bioorthogonal tools³ that enabled us to tag the …

This Nature study shows how aging slows protein cleanup in the brain, leading microglia to fill up with old synaptic proteins. Andrew Yang (BARI) contributed key methods to reveal it. Interesting for neurodegeneration research: pubmed.ncbi.nlm.nih.gov/41565824/ #neuroscience #brainaging

Fibroblast Modulation of Stem Cell Lineage Infidelity and Metaplasia in Tissue Fibrosis - PubMed Epithelial stem cells are segregated on the basis of region-specific identities during homeostasis. However, tissue perturbations can induce remarkable plasticity in stem cells to adopt lineage identities outside their anatomical compartments. This phenomenon has been termed lineage infidelity or me …

Big congrats to BARI’s Tien Peng on his latest review! Diving into how fibroblasts steer stem cell plasticity & metaplasia in fibrosis, super relevant for lung aging & disease. Read it here: pubmed.ncbi.nlm.nih.gov/40839781/

Genetic and Carcinogenic Risks of Radiotherapy for Nonmalignant Diseases Radiotherapy is a valuable treatment option for a variety of nonmalignant diseases. As the indications for low-dose radiotherapy to benign conditions …

Key review by BARI member Jean Nakamura: Low-does radiotherapy for nonmalignant issues has low carcinogenic risk, particularly in older populations where these ailments hit hardest. Age, dose, & genetics matter too, read more here: www.sciencedirect.com/science/arti...

The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases In the last two decades, many gene mutations have been identified that when homozygous, lead to childhood neurological disorders, but when heterozygou…

Insightful review by BARI member Aimee Kao & team connects development and aging through lysosomal dysfunction and neuronal vulnerability. They highlight how proteostatic stress in high-stress life stages can lead to lysosomal clearance disorders. www.sciencedirect.com/science/arti... #Neuroscience

PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate - Nature Communications Pcm1 bridges centrosome asymmetry and polarized endosome trafficking to regulate radial glia progenitor fate decisions, balancing self-renewal and differentiation in zebrafish and human cortical organ...

Check out BARI member Su Guo’s @naturecomms paper where they uncover PCM1’s role in regulating daughter cell fate via centrosome-endosome interplay. www.nature.com/articles/s41... #neuroscience

Because of technical issues with the SciENcv website, NIH is extending a period of leniency accepting old format biosketches through May 2026 (see FAQ #5):

grants.nih.gov/faqs#/common...

Past, present and future perspectives on the science of aging - Nature Aging As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related diseas...

Fascinating perspectives on aging science in Nature Aging! BARI’s Dena Dubal offers insights on real-world translation, plus input from two of our advisory board members Vera Gorbunova & George Kuchel. Inspiring read: www.nature.com/articles/s43... #Aging #Science

Neil Risch and his BARI team have a paper out in AJHG: Predicted loss-of-function variants linked to serious diseases often don’t show up as expected in big biobanks. Why? Residual activity from the variant allele keeps some function going (leaky penetrance).