Congrats to all the winners - and a special shout out to my PhD mentor, Judith Kimble, for receiving the Thomas Hunt Morgan Medal for lifetime achievement in genetics!!

Phosphorylation-dependent tuning of mRNA deadenylation rates - Nature Structural & Molecular Biology Stowell et al. show that the intrinsically disordered region (IDR) of Puf3 binds the Ccr4–Not deadenylase complex using an extended interface. Phosphorylation of the IDR regulates the interaction to t...

The latest from our group (@lapassmore.bsky.social)! Congrats to James and the rest of the authors!

Phosphorylation-dependent tuning of mRNA deadenylation rates

www.nature.com/articles/s41...

I'm very excited that I have been elected as a Research Fellow at Clare Hall, University of Cambridge (@clarehallcambridge.bsky.social). It's a pleasure to join such a great community!

www.clarehall.cam.ac.uk/directory/br...

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

It was great to be able to present my PhD work at #EMBLProtein! Thanks to the organizers for the opportunity.

Great start to the EMBL translation control meeting with a keynote from @lapassmore.bsky.social. Excited for all the science to come. #EMBLProtein

Thank you so much, Judi!!

Thanks, Aaron!

Thank you, CJ!

Incredibly honored to be a Shurl and Kay Curci Fellow of the Life Sciences Research Foundation. Thanks to Marv and Judith for their support during my PhD and @lapassmore.bsky.social for her backing and mentorship in my postdoc work.

lsrf.org/current-fell...

A fun collaboration with @rasilab.bsky.social led by Rachael Bakker.

We used an RNA base editor to analyze at scale how substitutions within an RNA or RNA-binding protein affect binding.

doi.org/10.1101/2025...

Happy to see this work published in RNA, and thanks to the editors for the interview/Meet the First Author Feature! Surprisingly, we found that mutating an RNA binding protein's ability to bind RNA did not remove all biological function. #RNAsky #RNAbiology.

rnajournal.cshlp.org/content/31/5...

A higher order PUF complex is central to regulation of C. elegans germline stem cells Nature Communications - PUF proteins, conserved stem cell regulators, maintain germline stem cells with partner proteins in nematodes. Here, authors discover a complex of two FBF-2 PUF proteins and...

It was great working with Chen Qiu, Traci Hall, and all the other authors on this project! Using a combination of structural, biophysical, and in vivo stem cell analyses, we investigated how an RBP and a partner regulate adjacent binding elements in a critical RNA.
#RNAsky #RNAbiology
rdcu.be/d5pER

Thank you, Eugene!

The PUF RNA-binding protein, FBF-2, maintains stem cells without binding to RNA Like all canonical PUF proteins, C. elegans FBF-2 binds to specific RNAs via tripartite recognition motifs (TRMs). Here we report that an FBF-2 mutant protein that cannot bind to RNA, is nonetheless b...

I’m excited to share this story. We found that mutating an RNA binding protein’s ability to bind RNA did not remove all biological function, but when combined with a mutation that affects protein interactions, the RBP no longer functioned.

www.biorxiv.org/content/10.1...

We also found that partnerships drive a spatially patterned switch from repression to activation of the target gld-1. Huge thanks to everyone who contributed to this work and all the members of the Kimble/Wickens groups over the years! 2/2

First Bluesky post, and I'm so excited to share our latest work, online today! We found a protein-protein interaction interface on a Pum/Puf protein mediates binding to a specific subset of RNA targets, and in turn affects only one of its functions in stem cells. 1/2

www.cell.com/developmenta...