Intracellular cysteine partitioning between glutathione and iron-sulfur metabolism is a critical metabolic decision that controls CD8+ T cell proliferation and effector function @cellcellpress.bsky.social @hopkinsmedicine.bsky.social #PearceLab
www.cell.com/cell/fulltex...

Apply here:
Laboratory Technician: roswellpark.wd5.myworkdayjobs.com/en-US/Extern...

Senior Laboratory Technician: roswellpark.wd5.myworkdayjobs.com/en-US/Extern...

Please share or tag someone who may be a great fit!

This is a great opportunity to gain hands-on research experience, work alongside supportive colleagues, and contribute to impactful cancer research at a mission-driven comprehensive cancer center in Buffalo, NY.

The #LongoLab at Roswell Park @roswellpark.bsky.social is seeking a Laboratory Technician and a Senior Laboratory Technician to join a highly collaborative, fast-paced research team studying how metabolism and nutrition influence the immune system's ability to fight cancer.

Our new paper about how the immune system is rewired when food availability is reduced! An awesome team effort by Luisa Menezes Silva, Mingeum Jeong and @seongji1.bsky.social.

Thanks, Vuk!

Stay tuned for updates and job postings. If you’re a trainee interested in studying tumor #immunometabolism, please reach out!

I’m deeply grateful to the many people who have helped me get to this point, with special thanks to my postdoc mentor, Dr. Rusty Jones, and the members of the Jones Lab @vai.org

I’m thrilled to share that I’ll be starting my lab on Jan. 20 in the Dept. of Immunology at @roswellpark.bsky.social. Our research will focus on how #metabolism regulates the growth and function of #cancer and immune cells, with the goal of identifying new strategies to enhance anti-tumor #immunity.

Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵

Study reveals how dietary restriction helps fuel cancer-fighting immune cells – Van Andel Institute Read about Study reveals how dietary restriction helps fuel cancer-fighting immune cells on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and heal...

Modestly limiting calories promotes the formation of ketones, which act as “fuel” for T cells, reports a study in @natmetabolism.nature.com by Dr. Rusty Jones & colleagues. The findings pave the way for developing diets to boost the effects of cancer immunotherapies.
www.vai.org/article/stud...

Congrats to Dr. Russell Jones for being named to this year’s @clarivate.com Highly Cited Researchers list — a distinction marking him as a leader in his field.

Read more: vai.org/hcr-2025
#HighlyCited2025 @clarivateag.bsky.social

Welcome to VAI, @jdlicht.bsky.social!

🪰Finally our study is in print — and we’re thrilled to see it featured on the cover of @natmetabolism.nature.com ! 🎉 #Drosophila #DevBio

Congratulations to the 7 recipients of the CRS’ 2025 Next Generation of Scientists Awards! They represent the future of cancer research in Canada.

🔬 Learn more: loom.ly/K8h1z4E

#Cancer #Research #NextGenerationOfScientistsAwards

Nutrient allocation fuels T cell-mediated immunity Glucose has traditionally been considered the primary fuel for T cells. Longo et al. present evidence for a revised, “nutrient allocation” model, in which effector T cells channel diverse nutrient sources into specific metabolic pathways to fuel T cell-mediated immunity.

Online now: Nutrient allocation fuels T cell-mediated immunity

It's National Postdoc Appreciation Week! We are proud to recognize our stellar postdocs, whose curiosity and dedication help drive our mission to improve health and enhance lives. Thank you for your outstanding work! 💙 #NPAW2025
www.vai.org/research/pos...

Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...

Rewiring of cortical glucose metabolism fuels human brain cancer growth

www.nature.com/articles/s41...

Congrats to the many involved, including @lyssiotislab.bsky.social and @dnagrathlab.bsky.social

‘Sweet’ discovery reveals how glucose fuels cancer-fighting immune cells – Van Andel Institute Read about ‘Sweet’ discovery reveals how glucose fuels cancer-fighting immune cells on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.

A new study, led by VAI’s Dr. Russell Jones and published in @cp-cellmetabolism.bsky.social, reveals that glucose, long known as a vital fuel for immune cells, also plays a key role in helping cancer-fighting T cells communicate and function effectively. www.vai.org/article/swee...

What’s next in metabolism research? – Van Andel Institute Read about What’s next in metabolism research? on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.

What’s next in metabolism research? VAI’s Metabolism and Nutrition (MeNu) Program recently asked top experts to forecast their bold ideas. Read about six areas they said are primed for discovery: www.vai.org/article/what...

Resolving early embryonic metabolism in Drosophila through single-embryo metabolomics and transcriptomics Nature Metabolism - By developing a method for single-embryo multi-omics in Drosophila, the authors provide a high-resolution view into the transcriptional and metabolic underpinnings of early...

🚀 Our new study is out in Nature Metabolism!
We used single-embryo metabolomics and transcriptomics to map the earliest metabolic transitions in Drosophila development, including the onset of zygotic metabolism.
Explore the dataset & findings:
🔗 rdcu.be/eAH12

#DevBio #metabolomics #Drosophila

📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Highlights:

I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...

Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control Glucose is required for T cell proliferation and function, but its key metabolic fates in vivo are not well defined. Longo et al. demonstrate that in CD8+ effector T cells, glucose metabolism extends ...

Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control: Cell Metabolism www.cell.com/cell-metabol...

Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control Glucose is required for T cell proliferation and function, but its key metabolic fates in vivo are not well defined. Longo et al. demonstrate that in CD8+ effector T cells, glucose metabolism extends beyond energy production by fueling glycosphingolipid biosynthesis, a pathway critical for T cell expansion and cytotoxic function.

Online now: Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control

Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control
@cp-cellmetabolism.bsky.social @drrgjoneslab.bsky.social
www.cell.com/cell-metabol...

I'm delighted to share that this story is now published in Cell Metabolism @cp-cellmetabolism.bsky.social - Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control: www.cell.com/cell-metabol...

ACLY inhibition promotes tumour immunity and suppresses liver cancer - Nature Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of ...

Targeting tumour metabolism through ATP citrate lyase can rewire immune function and suppress #cancer progression in #MASH #HCC www.nature.com/articles/s41...

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

Preclinical data reveal that dietary fat sources differentially regulate natural killer and CD8 T cell infiltration and function within the tumour microenvironment, governed by distinct effects on the plasma metabolome and intracellular metabolism. www.nature.com/articles/s42...