I’m excited to share that my PhD work is now published in @natcomms.nature.com! Big thanks to @davidsuter.bsky.social & @beatfierz.bsky.social for your guidance throughout this work. We show that electrostatic differences in disordered regions control TF search and chromatin invasion.
More details👇
The work of Xingyu Liu @xingyuliu9595.bsky.social in collaboration with Wei Cai in Beat Fierz @beatfierz.bsky.social group @lcbm-epfl.bsky.social and Anne-Sophie Chauvin on peptide-cyanoarenes used as photocatalysts is now accepted in @angewandtechemie.bsky.social !
doi.org/10.1002/anie...
Congrats to @alexateslenko.bsky.social for the amazing work, and of course our colleagues @lcbm-epfl.bsky.social and EPFL for their support!
Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...
I am very happy to share that I was awarded a PhD fellowship from the Boehringer Ingelheim Fonds (BIF) for my project about nucleosome depletion in @lcbm-epfl.bsky.social with @beatfierz.bsky.social. Looking forward to joining the BIF community 😊🥳
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
Don’t miss tomorrow's in-person #chembio seminar by Prof. Dr. Nina Hartrampf @ninahartrampf.bsky.social
👉 "New Methods for the Chemical Synthesis of Post-Translationally Modified Peptides and Proteins"
⏱️🇨🇭16:15 › 17:15
📢 bit.ly/3MOjVjy
Always nice to share the ideas together! Many THX to who show interest and ideas in our project 🙏 If interested in TF target search, feel free to contact us 📧 @beatfierz.bsky.social @davidsuter.bsky.social
THX to the EMBL travel grant for me to attend such great conference #EMBLOmics
🎖️ Yesterday PhD #Benjamin won a presentation price at the LS2 sub-section meeting – nice recognition for his careful #DyeCycling work! 🟢🔴🧬
Many thanks to @beatfierz.bsky.social, #KatjaOdening & all for organizing!
Also great to meet the 🇨🇭 community, #SimonScheuring, #ChanCao, #WayneYang ...👌
That is great, congrats!
Are you looking for a PhD position in peptide synthesis, automation, and computational analysis? 🧪 💊💻
We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: jobs.uzh.ch/job-vacancie...
⏰ Application deadline = November 15
Want to see how PRC1 writes the Polycomb ubiquitin mark on chromatin, in real-time? Check out our latest preprint, done all by Alexandra Teslenko at ISIC EPFL, a tour-de-force of single-molecule enzymology!
www.biorxiv.org/content/10.1...
Lots of movement on bsky, it’s getting lively!
Want to see how PRC1 writes the Polycomb ubiquitin mark on chromatin, in real-time? Check out our latest preprint, done all by Alexandra Teslenko at ISIC EPFL, a tour-de-force of single-molecule enzymology!
www.biorxiv.org/content/10.1...
Looking forward to it, and see you all there!
Check out the new review from @carlosmyruela.bsky.social on the using synthetic chromatin to investigate the function of histone deacylases! doi.org/10.1042/BST2...
Impressions from the LCBM Xmas party.!Happy holidays!!! 🎄🎁🎅🏽
Check out our work on centro-chromatin, where CENP-A and CENP-B collaborate to generate a dynamic chromatin state! A great collaboration between Nikolina Sekulic’s lab & us, and the labs of Mario Halic and Tatsuo Fukagawa. Congrats Harsh and Ahmad! www.nature.com/articles/s41...
The work of Xingyuu Liu and Jerome Waser, in collaboration with us and the Radenovic lab and funded within project SeleCHEM (ERC), on the gold catalyzed macrocyclization of peptide-EBXs to make fluorescent macrocycles is now in JACS! pubs.acs.org/doi/10.1021/...
Are you a junior scientist 🏋️ in 🇨🇭#chembio, 🔎opportunities for lasting professional relationships & showcase your research? 🧪🔬 👉🏻 ask your PI to join the SNE #ChemBio network! 👉🏻 submit your request bit.ly/3QuphmC #ChemicalBiology #Networking #ChemBio
Another exciting position at EPFL in Life Science Engineering, spanning the disciplines of: synthetic, systems and computational biology, cellular and tissue engineering, biomaterials, functional genomics, proteomics and metabolomics! Find the details here: www.epfl.ch/about/workin...
Congratulations to PhD student Arthur Despois for his poster prize at the joint posters exhibition of SCGC-EDCH! actu.epfl.ch/news/best-po...
We are hiring! We look for Postdocs in the field of biophysics / chemical biology of gene regulation within a context of a SNSF Advanced Grant starting in 2024! More details here: www.epfl.ch/schools/sb/r...
Are you developing new biosynthesis and/or green chemistry approaches? Here is a tenure track faculty position that might be of interest to you! There is less than a month left to apply for this position (deadline Oct 15)! So, apply here and join us at EPFL!
www.epfl.ch/about/workin...