CIRM Organoid and Organ-Chip Shared Resources Laboratory Explore the Organoid and Organ-Chip Shared Resources Lab at Cedars-Sinai, advancing basic research with cutting-edge tools, training and expertise.

The website for our new @cirmnews.bsky.social Organoid and Organ-Chip Shared Resources Lab is now live!

We offer training, services, and shared equipment to support stem cell researchers across California. Take a look!🔬🧫

www.cedars-sinai.edu/health-scien...

CDC is pulling back $11B in Covid funding sent to health departments across the U.S. “Now that the pandemic is over, the grants and cooperative agreements are no longer necessary," federal health authorities wrote to funding recipients this week.

I got the news this morning on two COVID related grants that were being terminated because its no longer seen as a research priority by Health and Human Services. My people have been given their notice. I have no words to express my feelings.
www.nbcnews.com/health/healt...

Saying ‘pandemic is over,’ NIH institute starts cutting COVID-19 research Grant terminations halt research on improving vaccinations and preventing future pandemics

...a “pointless, ill-advised move that will hurt U.S. science and pandemic readiness,” says Charles Rice, a Nobel Prize–winning virologist at Rockefeller University

www.science.org/content/arti...

I can confirm this. We were studying COVID and vaccine response in cancer patients. The pandemic isn’t over for them. Out grants specialist got an email letting us know the funding was terminated. Our PO didn’t even know.

Top 4 things to know about doing science:
1. You need to have someone you can talk to
2. One-on-one discussions are the best
3. Think about discussions as improvisations and use the ‘yes, and’ rule
4. Create a safe space so both of you feel open to saying seemingly silly things

A new paper by @tcell.bsky.social and team makes important advances towards improving CAR-T technology!

Read the paper here: www.biorxiv.org/content/10.1...

Listen to Omer talking about the paper and his spin-out company MatchBio here: podcasts.ox.ac.uk/series/immun...

Functional differences between rodent and human PD-1 linked to evolutionary divergence A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity.

Scientists have identified functional differences between human and mouse PD-1, which could impact preclinical research on cancer immunotherapies.

Read more in #ScienceImmunology:

Now online in Cancer Discovery: Effects of an Initial Anti-CD19 CAR T-cell Therapy on Subsequent Anti-CD22 CAR T-Cell Manufacturing and Clinical Outcomes in Patients with Relapsed/Refractory LBCL by Yi-Jiun Su, Matthew Frank, and colleagues doi.org/10.1158/2159... @stanfordmedicine.bsky.social

I always thought that the first step in the scientific method was observation. Hypothesis was the second step. Isn’t “fishing” really about making observations? Yeah, my grant reviewers didn’t buy it either.

Asparagine availability controls germinal center B cell homeostasis Asparagine metabolism is a critical regulator of germinal center B cell function.

This week in #ScienceImmunology: Germinal Center B cells require asparagine (Asn) #metabolism for their function. GC B cells can acquire exogenous Asn from their local environment, but when Asn is limited, they utilise the enzyme asparginine synthetase. @ajclarke.bsky.social @yfy1.bsky.social

meme showing ma looking at 2145661(1) PDF file while other girl named 2145661.PDF looks on angrily

Not sure who made this & when but fittingly came across it in my downloads folder today:

Please add me

Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT Perturb-seq enabled the profiling of transcriptional effects of genetic perturbations in single cells but lacks the ability to examine the impact on tissue environments. We present Perturb-DBiT for si...

#Crispr and #spatial all in one … yes please… perturb-dbitseq.

www.biorxiv.org/content/10.1...

Please add me. Thanks

The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?

direct.mit.edu/qss/article/...

A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub

I think this could heal the partisan divide

Climate gets warm enough, might make sense.

Nice work. PTCY for the win once again.

Its has to be like version 1 of the web. Before everything was engagment and eyeballs. Thats whats brings the drama and conflict--the need to drive engagment.

Add me please.

Ok wow, seems like now I am seeing posts of cats and dog who have lymphoma. Hmm...

Ok, so far it seems like the Bluesky algorithm thinks I want to see pictures of pets. I use social media mostly to keep up with what's new in science. Specificallly, lymphoma, tumor immunology, spatial profiling. Can folks suggest accounts to follow?

Hello, world?