It‘s been a pleasure to host @mucubacter.bsky.social as a guest speaker for the CRC1371 #microbiomesignatures here at #TUM. Fantastic talk on #microbiome #diet #antibiotic and #mucus projects, and great exchanges! Thank you for your visit Björn! #mucusmatters

ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal cancer in humans and mice, thereby linking endoplasmic reticulum stress responses to lipid metabolism and tumorigenesis.

RESEARCH |
@ocoleman.bsky.social , Sorbie, Haller et al. (TUM)

ATF6 causes an enrichment in long-chain fatty acids in the colon, which contributes to the development of colorectal cancer🧪

For an extra read, check out the associated blog post: communities.springernature.com/posts/unrave...

I recently had the pleasure of a short stay at the University of Gothenburg, hosted by Elisabeth Nyström. Many thanks to Liz and everyone in the Mucin Biology groups for the warm welcome and stimulating scientific exchange. Looking forward to continuing our collaboration! #mucusmatters

@ocoleman.bsky.social way to go!

@ocoleman.bsky.social way to go!

Thank you for including our Paper as a highlight! for anyone interested in the accompanying blog post: go.nature.com/4mFNYdb

For an extra read on our new publication in #naturemetabolism, read my Blog Post: Unravelling how the stress sensor ATF6 stirs up trouble (and tumors)
communities.springernature.com/posts/unrave...
#lifesciences #colorectalcancer #microbiota #erstress #metabolism

ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal ca...

Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences
www.nature.com/articles/s42...

🚀 What’s it like to launch a new lab? Hans-Georg Sprenger shares challenges, early wins & the joy of mentoring in molecular metabolism research. @mpiage.bsky.social
Read the interview: febs.onlinelibrary.wiley.com/doi/10.1002/...
#ScienceCareers #Mentoring #ResearchLife

a man wearing headphones sits at a desk with a laptop on it on the beach ALT: a man wearing headphones sits at a desk with a laptop on it on the beach

Road trip starts tomorrow. Journal proofs still MIA. Guess the laptop’s coming after all… #academiclife #firstauthorpriviliges

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

This isn't the crispest image, unfortunately, but getting my mouse intestinal organoid to take on the shape of a mouse (nibbling on a chow pellet?) is my achievement of the week 🤩

p.s. @gobletcellguy.bsky.social: this is the mCherry Muc2...the signal is definitely there 🤜

@hallerlab.bsky.social @adamsorbie.bsky.social

Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer AbstractBackground and aims. Chronic inflammation in inflammatory bowel disease (IBD) patients represents a risk factor for developing colitis-associated c

Happy to share our latest paper showing that intestinal inflammation (IL10-/-) + an UPRER diva protein (ATF6) = a perfect storm for colon cancer: Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer. academic.oup.com/ecco-jcc/art...

The 5th Ghent Gut Inflammation Group Meeting #GGIG2025 is live! 🚨 Hosted by Ghent University & VIB, this 2-day event spotlights junior scientists in gut research. Great start with Jochem Bernink of @amsterdamumc.bsky.social on immune-mediated regeneration in the gut! More info: vibbio.tech/GGIG2025

Happy to see this finally published 🙌 Thanks to the editors and reviewers for the constructive process 😎

It‘s been a pleasure to host @mucusman.bsky.social as a guest speaker for the CRC1371 #microbiomesignatures here at #TUM. Two days filled with productive and fun #gobletcell exchanges and a fantastic talk on #mucus #autphagy #erstress and #antibiotics. Thanks for making the trip Shai! #mucusmatters

For all the #mucus fans out there who believe in our knight in slimy armour and want to join the starter pack 👇 contact @gobletcellguy.bsky.social
#mucusmatters

Great thanks!

a man standing in a hallway with the words listen i know i 'm late i can explain ALT: a man standing in a hallway with the words listen i know i 'm late i can explain

Better late than never...finally made the move to #bluesky!
I am back from #maternityleave and excited to dive into the science world again, and catch up on #mucus updates ✌️ I've probably missed lots 😱 #mucusmatters #academicchatter #academicmum