#ERStress activates IRE1α–XBP1s to upregulate hIAPP transcription via an ACGT site, driving β-cell dysfunction in #type2diabetesmellitus (#T2DM); blocking #XBP1 splicing with MKC3946 lowers IAPP and improves β-cell survival.
#OpenAccess: doi.org/10.1016/j.ge...

Insights into the interplay between #ERstress & necroptosis, detailing the regulatory role of UPR in the #Pathogenesis of necroptosis-related diseases, & the therapeutic potential of targeting UPR-mediated pathways.

#OpenAccess: doi.org/10.1016/j.ge...

🦠 We are pleased to share this outstanding study elucidating how SARS-CoV-2 spike proteins trigger host unfolded protein response.

📕 HAX1 mediates SARS-CoV-2 spike-triggered unfolded protein response in host cells

Discover ➡️ buff.ly/xKpmaKx

#Highlights2025 #SARSCoV2 #spike #UPR #ERstress

Melatonin alleviates Slc26a2-associated chondrodysplasias by reducing ER stress and chondrocyte apoptosis.
#Chondrodysplasia #Slc26a2 #Melatonin #ERStress #ChondrocyteApoptosis #CartilageBiology
www.sciencedirect.com/science/arti...

By attenuating #ERstress and chondrocyte #Apoptosis, melatonin mitigates Slc26a2-associated #Chondrodysplasias, promoting #Chondrocyte survival, partially alleviating growth retardation, and improving trabecular #BoneFormation. #medsky

#OpenAccess: doi.org/10.1016/j.ge...

Alternative splicing is a major driver of signaling diversification in plants.
🔗 [https://onlinelibrary.wiley.com/doi/10.1111/pce.70220]
#PlantScience #ERStress #Saltstress

#HutchinsonGilfordProgeriaSyndrome

Intriguing 🐭data showing that Progerin-induced #ERStress #UnfoledProteinResponse in Aorta is NOT EC-origin

Evidence from
1⃣Cdh5-tTA:tetop-LA G608G 🐭
2⃣Lmna G609G knockin 🐭

#LSA 2025
www.life-science-alliance.org/content/9/2/...

IRE1α (encoded by ERN1) negatively regulates postnatal growth plate development by accelerating #ChondrocyteHypertrophy & #CartilageMineralization via impairing homeostasis of the crucial IHH and PTHrP/PTH1R feedback loop & #ERstress. #medsky

#OpenAccess: doi.org/10.1016/j.ge...

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat-stressed spermatogonial cells in vitro

👉 buff.ly/ZBKlHhu

#ERstress #Spermatogenesis #Salubrinal

Yinchenhao Decoction Combined with Praziquantel Ameliorates Inflammation

This study shows that yinchenhao decoction + praziquantel mitigates schistosomiasis-associated hepatic granulomatous #Iinflammation and #Fibrosis by inhibiting hepatic #Apoptosis & #ERstress in a #Schistosomiasis mouse model. #medsky

Read: doi.org/10.1007/s115...

Chop Deficiency Exacerbates Cyclophosphamide

Chop deficiency exacerbates #Inflammation, tissue injury, macrophage infiltration and bladder epithelial apoptosis in #cyclophosphamide-induced overactive bladder (OAB) by inhibiting #ERstress.

Read: doi.org/10.1007/s115...

The canonical #ERstress IRE1α/XBP1 pathway mediates skeletal muscle wasting during #PancreaticCancer #cachexia

By A. Joshi, A. Kumar & colleagues @uh.edu

🗞️ doi.org/10.1038/s443...

Online today! Inhibiting #cholesterol synthesis halts #rhabdomyosarcoma growth via #ERstress and cell cycle arrest

By N.Y. Gisaw, @riikka-k.bsky.social & colleagues @helsinki.fi @wrihelsinki.bsky.social

🗞️ doi.org/10.1038/s443...

Differential stress responses of immunoisolated human islets embedded in pancreatic extracellular matrix under static and free-fall dynamic conditions
Journal of Tissue Engineering
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#ERstress #ECM #diabetes #endocrinology #openaccess

Ever wonder why people with #ME/CFS or long #COVID feel exhausted for days after mild activity? This review discusses mitochondrial dysfunction as a potential shared mechanism and therapeutic target.

Abu Mohammad Syed, et al.
➡️ https://ow.ly/LO4p50Xe7f3
#mitochondria #ERstress #WASF3

#VascularCalcification Mechanobiology

#HydrostaticPressure 120 mmHg 7 d➡️
⏫#Piezo1➡️ (⏫ #ERStress GPR78 CHOP➡️)
⏫ #SmoothMuscleCell Calcification (~20% level by 4 mM Pi)

#BBAMolBasisDis 2025
www.sciencedirect.com/science/arti...

Unravelling how the stress sensor ATF6 stirs up trouble (and tumors)

For an extra read on our new publication in #naturemetabolism, read my Blog Post: Unravelling how the stress sensor ATF6 stirs up trouble (and tumors)
communities.springernature.com/posts/unrave...
#lifesciences #colorectalcancer #microbiota #erstress #metabolism

ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal ca...

Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences
www.nature.com/articles/s42...

Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling Nature Communications - Santos et al found that the ubiquitin ligase adaptor Fbxo42 is a critical regulator of terminal Unfolded Protein Response signaling through its control of Ataxin-2 granules...

rdcu.be/eABGi
Recent work from our Lab and colaborators
#ERStress #RNABindingProteins #Drosophila

Unidirectional Crosstalk Between NTRK1 and IGF2 Drives ER Stress in Chronic Pain Background: Chronic postsurgical pain (CPSP) poses a major clinical challenge due to unresolved links between neurotrophic pathways and endoplasmic reticulum (ER) stress. While Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) modulates ER stress in neuropathic pain, its interaction with Insulin-Like Growth Factor II (IGF2) in CPSP remains uncharacterized, impeding targeted therapy. This study defined the spinal NTRK1-IGF2-ER stress axis in CPSP. Methods: Using a skin/muscle incision–retraction (SMIR) rat model, we integrated molecular analyses and intrathecal targeting of NTRK1 (GW441756) or IGF2 (siRNA). Results: SMIR surgery upregulated spinal NTRK1, IGF2, and ER stress mediators. NTRK1 inhibition reduced both NTRK1/IGF2 expression and ER stress, reversing mechanical allodynia. IGF2 silencing attenuated ER stress and pain but did not affect NTRK1, revealing a unidirectional signaling cascade where NTRK1 drives IGF2-dependent ER stress amplification. These findings expand understanding of stress-response networks in chronic pain. Conclusions: We show that spinal NTRK1 drives IGF2-mediated ER stress to sustain CPSP. The NTRK1-IGF2-ER stress axis represents a novel therapeutic target; NTRK1 inhibitors and IGF2 biologics offer non-opioid strategies for precision analgesia. This work advances CPSP management and demonstrates how decoding unidirectional signaling hierarchies can transform neurological disorder interventions.

Spinal NTRK1→IGF2→ER stress fuels chronic #Postsurgical #Pain 🤯 🔥SMIR rats: block NTRK1 or silence IGF2=pain relief🩹🧬A non‑opioid precision #Analgesia target 🚀 🔬 @mdpiopenaccess.bsky.social #CPSP #NTRK1 #IGF2 #ERstress #Pain
doi.org/10.3390/biom...

Spinal NTRK1→IGF2→ER stress fuels chronic #Postsurgical #Pain 🤯 🔥SMIR rats: block NTRK1 or silence IGF2=pain relief🩹🧬A non‑opioid precision #Analgesia target 🚀 🔬 @mdpiopenaccess.bsky.social #CPSP #NTRK1 #IGF2 #ERstress #Pain
doi.org/10.3390/biom...

What if chronic postsurgical pain isn’t nerve damage—but a stress loop? 😖🧠⚙️ SMIR rats: NTRK1 ➡️ IGF2 ➡️ ER stress 🔁 pain. Block NTRK1, break the cycle. Non-opioid targets🚫💊 @mdpiopenaccess.bsky.social #PainResearch #Neuroscience #ERstress #PrecisionMedicine #CPSP
Read & RT👇
doi.org/10.3390/biom...

What if chronic postsurgical pain isn’t nerve damage—but a stress loop? 😖🧠⚙️ SMIR rats: NTRK1 ➡️ IGF2 ➡️ ER stress 🔁 pain. Block NTRK1, break the cycle. Non-opioid targets🚫💊 @mdpiopenaccess.bsky.social #PainResearch #Neuroscience #ERstress #PrecisionMedicine #CPSP
Read & RT👇
doi.org/10.3390/biom...

Endoplasmic reticulum stress responses in anticancer immunity - Nature Reviews Cancer The endoplasmic reticulum (ER) has a central role in mounting effective and durable antitumour immunity. In this Review, Hwang et al. outline how tumour-induced ER stress responses alter the function of intratumoural immune cells and the efficacy of immunotherapy, highlighting the potential of unfolded protein response-targeted interventions to improve cancer outcomes.

REVIEW🚨

Rodriguez, Cubillos-Ruiz &Co discuss how the #ERstress response affects intratumoural immune cells & highlight the potential of #UPR-targeted interventions to improve cancer outcomes.

👀⬇️

This week's #ThrowbackThursday in JHC: "Increased ER Stress and Unfolded Protein Response Activation in Epithelial and Inflammatory Cells in Hypersensitivity Pneumonitis."

Click to read for FREE: bit.ly/4ea9C5I

#epithelialcells #inflammation #ERstress

🔓#OpenAccess: Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Abu Mohammad Syed,
doi.org/10.1152/phys...
#mitochondria #ERstress

DEHP induces a ROS-mediated imbalance in #pyroptosis and #mitophagy in immature rat testes via XBP1, suggesting that XBP1 might be the key target in DEHP-related testis dysfunction. #ERstress #spermatogenesis #medsky

#OpenAccess:
www.sciencedirect.com/science/arti...

Role of the translation factor EIF2A in protecting #BetaCells during #ERStress #DiabetesResearch #Isets #MedSky @jimjohnsonsci.bsky.social @bruceverchere.bsky.social

Can mild sleep loss mess with your brain? 😴🧠

New study shows just 1.5 hrs less sleep can trigger stress pathways and disrupt neural stem cell functions 🧬

🔗 www.cell.com/iscience/ful...

#SleepScience #Neuroscience #Multiomics #StemCells #WomensHealth #OpenAccess #iScience #ERStress #BrainHealth

How is #Proteoglycan #Glycosaminoglycan accumulated in #ThoracicAorticAneurysm?😎
#AortaEd

An overactivation of #HexosamineBiosyntheticPathway-GAG-#IntegratedStressResponse #ERStress PERK eIF2α ATF4 cascade

@jorgeoller.bsky.social bioRxiv 2024
www.biorxiv.org/content/10.1...