Ever wonder why people with #ME/CFS or long #COVID feel exhausted for days after mild activity? This review discusses mitochondrial dysfunction as a potential shared mechanism and therapeutic target.

Abu Mohammad Syed, et al.
➡️ https://ow.ly/LO4p50Xe7f3
#mitochondria #ERstress #WASF3

directly with how mitochondria produce energy. In muscle samples from 14 patients compared with 10 healthy volunteers, most ME/CFS samples showed substantially higher WASF3 levels.

#ME/CFS #Mitochondria #WASF3 #AMD (Acquired Mitochondrial Disease) #SEID (Systemic Exertion Intolerance Disease)

So it probably identified a much larger group than ME/CFS.”

Nevertheless it would be great if the findings from the @decodemestudy.bsky.social found the same gene among the polygenic hits which can be involved in #ME/CFS. #WASF3

Our analysis identified eleven genes which may play important roles in certain aspects of #ME/CFS or related symptoms. In particular, the gene #WASF3 (aka WAVE3) possibly regulates brain cytokines involved in the mechanism of fatigue through the p38 MAPK regulatory pathway.

Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data We start by constructing gene-gene association networks based on about 300 genes whose expression values vary between the groups of CFS patients (plus control). Connected components (modules) from the...

While we wait for the @decodemestudy.bsky.social #GWAS study results to be published 8/6/25 @ 7 pm GMT let us review these 2011 findings #ME/CFS #WASF3
Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data

WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome P. M. Heang et al. (2023) www.pnas.org/doi/10.1073/... #ME/CFS #WASF3 #Mitochondria

Woman who beat breast cancer twice inadvertently furthers long Covid research In her quest for an accurate diagnosis, she helped a top scientist learn more about symptoms caused by long Covid

After extensive study, they noticed that Twinam’s body seemed to be producing more than the normal amount of a protein called WASF3. This protein, they discovered, was plugging up the process by which her body was trying to produce energy.
#WASF3 #ME/CFS
www.independent.co.uk/student/stud...

Journal Club: WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome | Medical News Bulletin For decades, a mystery syndrome has struck down up to 130 million people worldwide. Crushing fatigue, difficulty in thinking clearly, muscle aches, exhaustion ...

#WASF3 disrupts mitochondrial respiration and may be the factor mediating the core exertion intolerance & #PEM in patients affected by #ME/CFS medicalnewsbulletin.com/journal-club...

NIH Scientists discover biological basis for ME/CFS symptoms | Medical News Bulletin A study published in Proceedings of the National Academy of Science sheds some light on the role of a protein that may prevent ME/CFS patients from generating normal amounts of cellular energy.

In 2023 a small group of NIH researchers, spearheaded by Dr P. Hwang made an important discovery that seems to explain one of the biological pieces in the disease we now call #ME/CFS. The paper was published in the prestigious PNAS medicalnewsbulletin.com/nih-scientis... #WASF3 #Mitochondria

A protein that disrupts cells’ energy centers may be a culprit in chronic fatigue syndrome New study offers clues as to how exhaustion could arise in people with ME/CFS—and potentially related conditions such as Long Covid

Een EIWIT #WASF3 dat de energiecentra van cellen verstoort, kan een boosdoener zijn bij chronisch vermoeidheidssyndroom
Nieuw onderzoek biedt aanwijzingen over hoe uitputting kan ontstaan ​​bij mensen met #MEcvs, en mogelijk gerelateerde aandoeningen zoals #LongCovid

www.science.org/content/arti...

A protein that disrupts cells’ energy centers may be a culprit in chronic fatigue syndrome New study offers clues as to how exhaustion could arise in people with ME/CFS—and potentially related conditions such as Long Covid

www.science.org/content/arti... #MECFS #pwME #WASF3

identified eleven genes which may play important roles in certain aspects of #MECFS or related symptoms. In particular, the gene #WASF3 (aka WAVE3) possibly regulates brain cytokines involved in the mechanism of fatigue through the p38 MAPK regulatory pathway.

Meta analysis of ME/CFS through integration of clinical, gene expression, SNP and proteomic data
Vasyl Pihur1, Somnath Datta2, Susmita Datta2*
1The Johns Hopkins University, Published April 22, 2011 #WASF3
www.bioinformation.net/006/97320630...

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

#WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome: www.pnas.org/doi/10.1073/... #MECFS #PwME