Optimal design for multi-compartment cell elasticity estimation using AFM and super-resolution imaging The transduction of external forces to the internal components of the cell has critical implications for cell behavior in health and disease. Despite …

here's out new work on cellular biomechanics (:

www.sciencedirect.com/science/arti...

check out our new work (:

Cohesin drives chromatin scanning during the RAD51-mediated homology search Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...

Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...

Native nucleosomes intrinsically encode genome organization principles www.nature.com/articles/s41...
▶️Condensed purified native mononucleosomes with polyamines
▶️Nucleosomes from A compartments have low condensability and those from B compartments have high condensability

Check out our new preprint! (: Lead by the incredible Jonghan Park in TJ Ha's lab.

Here, we explore how DNA stores and encodes information via its mechanical properties, rather than via base pairs, and how those properties can be selected for!

www.biorxiv.org/content/10.1...

Delighted to share my latest work, co-first authored with fantastic undergrad mentee Joshua Lee, on highly entangled hydrogels with photolabile crosslinks. We compare selective crosslink cleavage (which lengthens chains) to non-selective photo-oxidative degradation. pubs.rsc.org/en/content/a...

The stiffness of cells and their nuclei is a biomarker of several pathologies, yet is usually reduced to a single value. In our last paper, we propose a method to estimate heterogeneous maps of stiffness inside freely moving cells using only fluorescence imaging.
ieeexplore.ieee.org/document/107...

Piezo is on the #NuclearEnvelope 😆, mediating Apoptosis caused by defects in Homologous Pairing & Synapsis (Synapsis Checkpoint) during🪱#Oocyte #Meiosis

A novel #Celegans model of Auxin-inducible proximity (instead of degradation)
@adernburg.bsky.social #Science 2024
www.science.org/doi/10.1126/...

JDLL: a library to run deep learning models on Java bioimage informatics platforms.
@jytinevez.bsky.social @deepIcy_IP @deepImageJ

www.nature.com/articles/s41...

Engineering #OrganOnAChip Systems for Vascular Diseases

Material: PDMS
+Softer polyester
+Hydrogel (or Hydrogel with topological entanglement?😁)

Atherosclerosis-on-a-chip
Thrombosis-on-a-chip
PAH-on-a-chip
Aneurysm-on-a-chip

#ATVB 2023 @ahascience.bsky.social
www.ahajournals.org/doi/full/10....

Matter is now on bluesky! More to come soon!

mattercellpress.bsky.social

Global #CellVolume (not nuclear vol) Expansion drives collective invasion of #BreastCancerCell through #BasementMembrane

TRPV4- & Osmolality-dependent

Collective invasion doesn't need #Invadopodia

Ovijit Chaudhuri lab #NatureMaterials 2023
www.nature.com/articles/s41...

picture!

want to share our new work (:

www.cell.com/matter/fullt...

hello bluesky!