@karapedsgastrodoc.bsky.social

NEW PRC PAPER 🚨: A comprehensive and timely review from @harsh3b.bsky.social and Amedee des Georges examines how deep learning is automating model building in Cryo-EM, streamlining structure determination and accelerating structural biology workflows. www.frontiersin.org/journals/mol...

Congrats to PRC postdoc @linyhung.bsky.social on getting the AGA Research Scholar Award - an amazing achievement!

Congrats to the Shamsi Lab on this stellar paper! @farnazshamsi.bsky.social

@afshin419.bsky.social @yaldamoayedi.bsky.social @mariafialho.bsky.social @margolislabnyu.bsky.social @tonelloraquel.bsky.social @jimr-1.bsky.social @badrsokrat.bsky.social @elisadamo.bsky.social

Very proud of our group’s showing at #USASP2026! Thank you to the organizers of this fantastic meeting! @usasp.bsky.social @karapedsgastrodoc.bsky.social @sdavidson.bsky.social @sarahanajjar.bsky.social @yylab.bsky.social @goinsyeah.bsky.social @pazduran.bsky.social @keylinesc.bsky.social

Don’t miss Dr. Kara Margolis’ talk this afternoon at #USASP2026 on serotonin signaling in the gut-brain axis! @karapedsgastrodoc.bsky.social

Come see us at our presentations today at #USASP2026! @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @afshin419.bsky.social @mariafialho.bsky.social @sarahanajjar.bsky.social @goinsyeah.bsky.social

Please visit our posters today at #USASP! @karapedsgastrodoc.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @pazduran.bsky.social

@jimr-1.bsky.social @afshin419.bsky.social @keylinenotpie.bsky.social @yysquare.bsky.social @goinsyeah.bsky.social

We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science. @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @sdavidson.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @mariafialho.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social

Congratulations to the Margolis Lab on their standout translational study published in Gastroenterology! @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @linyhung.bsky.social

NEW PRC PAPER 🚨 This study led by @mariafialho.bsky.social from the Bunnett Lab reveals that tryptase from mast cells activates PAR2 on sensory neurons, sustaining painful symptoms induced by an aromatase inhibitor. buff.ly/lVAgUgO @tonelloraquel.bsky.social @karapedsgastrodoc.bsky.social

@karapedsgastrodoc.bsky.social

NEW PRC PREPRINT 🚨 The Jensen Lab presents a new therapeutic target for itch: Blocking AAK1 and Dynamin in GRP neurons reduces scratching without behavioral side effects. buff.ly/rpfcj90 @tonelloraquel.bsky.social @pazduran.bsky.social

@karapedsgastrodoc.bsky.social

Monocyte-derived IL-10 drives sex differences in pain duration Peripheral monocytes and IL-10 are associated with shorter pain duration in males in both mice and humans.

New research highlights a key sex difference in pain resolution: in males, androgen signaling promotes IL-10+ monocytes that "switch off" pain after inflammation. Congrats to the Laumet Lab team on this fantastic paper! @geoffroylaumey.bsky.social buff.ly/61wyU5C

Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis - Nature Neuroscience Su et al. show that inflammatory arthritis pain stems from sustained interferon-driven MNK1/MNK2–elF4E signaling that sensitizes joint-innervating neurons. Blocking this pathway reverses pain, suggest...

BOOM! Fantastic new paper from Patrik Ernfors and his team: www.nature.com/articles/s41... Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis

Huge congratulations to PRC Associate Director Steve Davidson on securing an NIH R01 to investigate new targets for diabetic neuropathic pain! #painresearch @sdavidson.bsky.social @yysquare.bsky.social @karapedsgastrodoc.bsky.social

NYU Research Competes for This Year’s Top Health Discovery Recent studies of C-sections, gut pain selected for STAT Madness 2026

Support groundbreaking science revealing how gut microbes drive intestinal pain! Vote for our PAR2 discovery in STAT Madness 2026.

@sarahanajjar.bsky.social @karapedsgastrodoc.bsky.social

We had the honor of hosting Prof Jose Moron-Concepcion from @washumedicine.bsky.social yesterday! He gave a fantastic seminar on novel therapeutic approaches to prevent pain-induced opioid escalation and fentanyl overdoses. @linyhung.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social

@karapedsgastrodoc.bsky.social @mariafialho.bsky.social

NEW PREPRINT 🚨 Why does IBS pain persist? PRC’s Nestor Jimenez-Vargas and the Bunnett Lab uncover how PAR2 signaling from endosomes amplifies fleeting histamine signals to sustain colonic nociceptor hyperexcitability. www.biorxiv.org/content/10.6...
@badrsokrat.bsky.social

Amazing opportunity!

On the cover of Science Signaling! Work in the Ye lab, led by Naijiang Liu and Xiaojie Shi, shows that blocking epidermal growth factor receptor signaling reduces oral cancer pain AND boosts opioid efficacy. www.science.org/doi/10.1126/...

Proud of Dr. Yi Ye and her team's outstanding work advancing our understanding of oral cancer pain and opioid tolerance. Check out the press release on these important findings! www.nyu.edu/about/news-p...

#PainResearch #DrugDiscovery #NRP1 #VEGF @karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social @pazduran.bsky.social

Quinoline-Based Neuropilin-1 Antagonists Exhibit a Pure Antagonist Profile and Block Vascular Endothelial Growth Factor-Induced Pain Nociceptive pain, resulting from tissue injury or inflammation, affects a large portion of the global population. This type of pain is commonly treated by small molecules that are associated with a va...

Exciting work introduces EG01449 (12h), a novel Neuropilin-1 (NRP1) antagonist. It inhibits NRP1, avoiding signaling drawbacks, and blocks VEGF-induced pain by mitigating channel currents in sensory neurons. NRP1 antagonism is a promising new modality for chronic pain. pubs.acs.org/doi/10.1021/...

What a day! ✨ The 1st NYC Area Pain Research Meet-Up blew us away — amazing energy, brilliant conversations, and an incredible community. Huge thank-you to everyone who attended and to all who helped bring this event to life. Already excited for the next one!