SPICE-GRADE: simultaneous processing of indirect causal evidence in complex pathways using GRADE - an exploratory case study - PubMed In this case study, we illustrate SPICE-GRADE as a structured way of mapping and assessing multiple causal links within the GRADE framework. Establishing SPICE-GRADE as a robust methodology for GRADE ...

Spice-GRADE: methodological breakthrough for #GRADE. New methods showing how indirect evidence from epidemiological investigations of mechanistic causal pathways can complement direct evidence.

pubmed.ncbi.nlm.nih.gov/41802581/

Closing the gap between research and practice💥
At #REMEDY 2026, Per Olav Vandvik highlighted how MAGIC Evidence Foundation helps turn RCTs into decisions that change care.
Evidence is not the endpoint. It is the starting point.
Trials → guidelines → implementation → patient decisions.
#MAGICevidence

💥New paper from #MAGICevidence community: #SPICEGRADE explores how to assess certainty of the evidence when causal inference relies on chains ⛓️ of indirect evidence.
An important step as evidence ecosystems become more complex:
www.jclinepi.com/article/S089...

This Rapid Recommendation is a summary of a WHO guideline for influenza
www.bmj.com/content/392/...

From the US to China and India: the power shift in clinical trials If you’re seeking to keep politics out of medicine, good luck with that. It isn’t possible. We’ve previously described the political determinants of health (doi:10.1136/bmj.h81),1 and next we’ll focus...

"The notion that medical research is a 'geopolitical football' is much more than a hypothesis. It is a stark, complex, and miserable reality."

@kamranabbasi.bsky.social in Editor's Choice
https://bit.ly/3MBGY4y

Celebrating 10 years of partnership between #MAGICevidence & @bmj.com
BMJ Rapid Recs have grown from rapid translation of evidence into 🌏 rigorous, transparent patient-informed guidance, while also serving as a laboratory for innovation.
Meeting in London was about celebration & renewed commitment

Smoking cessation for people with severe mental illness: systematic review and network meta-analysis Objective To evaluate the comparative effectiveness and safety of pharmacological and non-pharmacological smoking cessation interventions in people with severe mental illnessDesign Systematic review a...

New research📢

Geertruida Bekkering and colleagues compare the effectiveness and safety of pharmacological and non-pharmacological smoking cessation interventions in people with severe mental illness.

https://bit.ly/4kHE8Ye

MAGICapp was used worldwide in 2025: a shared infrastructure for evidence-based healthcare, supporting real decisions shaped by evidence, patient values, and global collaboration. Grateful to the community translating evidence into practice every day, everywhere.

A new Methods Primer by Dan Green and colleagues outlines circumstances where the mean and standard deviation alone are insufficient summary variables, and provides a simple appraisal method for reviewers without raw data

Read in BMJ Medicine now: https://bit.ly/4bJz3w8

Prospective registration of trials: where we are, why, and how we could get better Transparent trial conduct requires prospective registration of a randomized controlled clinical trial (RCT) before the enrollment of the first participant. We aimed to (1) estimate the proportion of R...

Do people register their #randomizedtrials before starting it ?
We studied more than 1000 RCT in #rheumatology to answer this question, to see how it evolved in time and how it varied between RCTs⬇️

Just published in @jclinepi.bsky.social :
jclinepi.com/article/S089...

#Metaresearch #EpiSky

Latest asked question about Core #GRADE, essence of the GRADE approach to #evidence certainty and moving to #recommendations in #BMJ in 2025. Addresses when and how much to rate down for #imprecision. Joins GRADE for single study and a priori hypotheses explaining #heterogeneity

t.co/hh6owWxn5O

Best wishes to all for 2026!

MAGIC’s 2026 priorities: expanding digitally structured guidelines with #MAGICapp, strengthening global capability through education & Core GRADE, advancing BMJ Rapid Recs and applied AI, and connecting the evidence ecosystem to improve real-world impact.

Open to collaboration in 2026 💥

[cont.] link to publication: bmjopen.bmj.com/content/15/1...

@thomasagoritsas.bsky.social @chrischampion.bsky.social

Hot off the press from the #MAGICevidence team.

New study on how guidelines translate into real-world use, focusing on BMJ Rapid Recs

Key message: Methodological rigor builds credibility, but complexity can undermine usability and confidence

Implementability needs to be designed, not assumed.

Old photo, guess 2010, recently recovered. The four people responsible for the MAGIC evidence ecosystem foundation – Per Vandvik, Thomas Agoritsas, Linn Brandt and me, along with former Chair of my department for a decade, Brian Haynes, and current Chair Alfonso Iorio.

@thomasagoritsas.bsky.social

The Geneva Conventions matter more than you may think YouTube video by Samia Hurst

youtube.com/shorts/zg6AK...

New in MAGICapp: you can now build Summary of Findings tables for Qualitative Evidence using the GRADE-CERQual framework.
A big step toward transparent, structured presentation of qualitative findings in guidelines and evidence syntheses.

#MAGICapp #GRADE #CERQual #QualitativeEvidence

At recent #GuidelinesInternationalNetwork (GIN) meeting with Thomas Agoritsas, Chair of the #MAGICEcosytemFoundation and international #GRADE methodology leader and our researcher Prashanti Eachempati, creator of the JUDGE instrument that will revolutionize GRADE education and practice.

Core #GRADE, 7 articles in #BMJ this spring, one-stop-shopping for those who want to get GRADE right with the essentials. Now also frequently asked question – latest post considers a priori hypotheses to explain #heterogeneity. All questions welcome, send to guyatt@mcmaster.ca

t.co/hh6owWxn5O

Decision support tools in the absence of equipoise: the case for vaccination Public health is in a bind. The goal of the discipline is to protect and improve the public’s overall health so that populations remain as healthy as possible. Public health considers decisions from a...

A situation where this is no equipoise yet shared decision making can be helpful ...

bmjpublichealth.bmj.com/content/3/2/...

Responding to public health challenges of medical advice from social media influencers Raffael Heiss and colleagues argue that influencers’ medical advice is often shaped by multiple biases and suggest how to reduce the associated risks Social media influencers have become powerful in ...

Challenges with medical advice from social media influencers www.bmj.com/content/391/...

Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health.

Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health.

Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health.

Ultra-processed foods – what’s the impact?

In a new Lancet Series, experts warn a global rise in #UPFs presents a growing public health threat.

Read the evidence & policy recommendations ⬇️
spkl.io/63327AduhR

Can we individualize the 'number needed to treat'? An empirical study of summary effect measures in meta-analyses - PubMed The fixed effects OR, random effects OR and random effects RR appear to be reasonably constant across different baseline risks. Given the interpretational and arithmetic ease of RR, clinicians may wis...

Are #RelativeRisks overwhelmingly similar across risk groups? And if so, can we personalize care by applying relative risk to individual patients’ risk profiles? This key #EBM study demonstrates that the answer to both questions is an unquestionable YES.
pubmed.ncbi.nlm.nih.gov/11914297/

Shared decision-making as a method of care Care happens in interaction between the patient and the clinician, in conversation where the patient and clinician uncover or develop a shared understanding of the problematic situation of the patient...

Forming #EvidenceBased plans of #EBM care that respond to each patient’s situation demands #SharedDecisionMaking. JP Brito, Iris Hargraves, and Marleen Kunneman are doing leading work to advance the practice of making care fit using shared decision making.

ebm.bmj.com/content/28/4...

🚨⚕️Enhancing clinical encounters: our new systematic review on how hospitals’ institutional programs could protect or increase the time dedicated to interactions.
It included 117 unique studies comprising 298,517 patients 👇

link.springer.com/article/10.1...

Interdisons les « thérapies de conversion » dans l’UE ! L’UE examine l’Initiative citoyenne européenne (ICE) visant à interdire les “thérapies de conversion” dans toute l’Europe. Les prochains mois seront décisifs : agiront-ils vraiment ou détourneront-ils...

L'UE examine l'Initiative citoyenne européenne (ICE) visant à interdire les "thérapies de conversion" dans toute l'Europe. Les prochains mois sont essentiels – assurons-nous qu'elle agisse. J'ai signé. Rejoignez-moi 👉 a.allout.org/s/OJyE5/

They founded MAGIC over ten years ago to improve how evidence is generated, translated, and used in clinical decisions. The goal was clear: more transparency, more trust, better patient care. Inspiring to see what it has become.
📸: Per Vandvik & @thomasagoritsas.bsky.social

15 minute #JAMA podcast in which I interview world authority @thomasagoritsas.bsky.social on how to Use a Patient Management #Recommendations: #ClinicalPracticeGuidelines and #DecisionAnalyses

edhub.ama-assn.org/jn-learning/...

A #MAGICal conversation between @guyattgh.bsky.social , MAGIC's lead methodologist, and @thomasagoritsas.bsky.social , MAGIC's Board Chair, featured in JAMA Network learning podcast 💥 on #CPG and decision analyses

Don't miss that out!
edhub.ama-assn.org/jn-learning/...