Adjusted Analyses in Studies Addressing Therapy and Harm: Users' Guides to the Medical Literature - PubMed Observational studies almost always have bias because prognostic factors are unequally distributed between patients exposed or not exposed to an intervention. The standard approach to dealing with this problem is adjusted or stratified analysis. Its principle is to use measurement of risk factors to …

The #JAMA Users’ Guide to the Medical Literature is the best existing tutorial on adjusted analysis taking the learner from the basic principles to regression and contrasting with propensity matching, highlighting the (limited) advantages of propensity.

pubmed.ncbi.nlm.nih.gov/28241362/

Hard to believe, but it is true! #ColorectalCancer is now the deadliest cancer for #Americans under 50, per new #JAMA research.

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Check out this study highlighted by #BodyPROHIV, featured in #JAMA that puts into perspective how #TelePrEP should be treated as a core option—but an option, not a requirement—within a modern HIV prevention toolkit. Read here: www.thebodypro.com/hiv/teleprep...

JAMA Ophthalmology Mission Statement: To be the indispensable source of ophthalmic knowledge by promptly publishing innovative, clinically relevant research through consistent and authoritative peer review and, thereby, to be the first choice of authors for their important manuscripts.

Ophthopedia Update: JAMA Ophthalmology: Mission Statement: To be the indispensable source of ophthalmic knowledge by promptly publishing innovative, clinically relevant research through consistent and authoritative peer review and, thereby, to be the first choice of… #Ophthalmology #Eyecare #JAMA

Subretinal Fluid and Optic Disc Edema in a Healthy Adult A 42-year-old man had a 1-year history of painless blurred vision and visual field defect in the right eye that had acutely worsened over the past month, and he reported headache and neck stiffness. What would you do next?

Ophthopedia Update: Subretinal Fluid and Optic Disc Edema in a Healthy Adult: A 42-year-old man had a 1-year history of painless blurred vision and visual field defect in the right eye that had acutely worsened over the past month, and he reported headache and neck… #Ophthalmology #Eyecare #JAMA

Ocular Manifestations of Biopsy-Proven B Virus Infection With Central Nervous System Involvement This case report describes a patient with B virus infection with clinical features including severe central nervous system dysfunction and bilateral panuveitis.

Ophthopedia Update: Ocular Manifestations of Biopsy-Proven B Virus Infection With Central Nervous System Involvement: This case report describes a patient with B virus infection with clinical features including severe central nervous system dysfunction and bilateral… #Ophthalmology #Eyecare #JAMA

Rapid Fluid Resolution and Durability With Faricimab in Neovascular Age-Related Macular Degeneration This post hoc analysis of the TENAYA and LUCERNE randomized clinical trials investigates whether rapid drying with faricimab, specifically intraretinal fluid and subretinal fluid resolution through week 12, is associated with later treatment durability.

Ophthopedia Update: Rapid Fluid Resolution and Durability With Faricimab in Neovascular Age-Related Macular Degeneration: This post hoc analysis of the TENAYA and LUCERNE randomized clinical trials investigates whether rapid drying with faricimab, specifically… #Ophthalmology #Eyecare #JAMA

New-Onset Nonarteritic Anterior Ischemic Optic Neuropathy and Initiators of Semaglutide in US Veterans With Type 2 Diabetes This observational study emulates a target trial evaluating the risk of NAION associated with initiation of semaglutide, compared with a sodium-glucose cotransporter-2 inhibitor as second-line therapy for type 2 diabetes in a nationwide cohort of US veterans.

Ophthopedia Update: New-Onset Nonarteritic Anterior Ischemic Optic Neuropathy and Initiators of Semaglutide in US Veterans With Type 2 Diabetes: This observational study emulates a target trial evaluating the risk of NAION associated with initiation of semaglutide,… #Ophthalmology #Eyecare #JAMA

Bisphosphonate-Associated Orbital Inflammation This case report describes a diagnosis of preseptal and orbital inflammation after intravenous infusion of the bisphosphonate zoledronate for osteoporosis in a woman aged 64 years.

Ophthopedia Update: Bisphosphonate-Associated Orbital Inflammation: This case report describes a diagnosis of preseptal and orbital inflammation after intravenous infusion of the bisphosphonate zoledronate for osteoporosis in a woman aged 64 years. #Ophthalmology #Eyecare #JAMA

Thyroid Eye Disease and the Prevalence of Human Papillomavirus This case-control study examines human papillomavirus and thyroid eye disease data from a large-scale centralized electronic health record database network.

Ophthopedia Update: Thyroid Eye Disease and the Prevalence of Human Papillomavirus: This case-control study examines human papillomavirus and thyroid eye disease data from a large-scale centralized electronic health record database network. #Ophthalmology #Eyecare #JAMA

Safety Evaluation of 4 Red Light Therapy Devices for Myopia This quality improvement study assesses the optical output and safety classification of 4 commercially available red light therapy devices for myopia management using American National Standards Institute guidelines.

Ophthopedia Update: Safety Evaluation of 4 Red Light Therapy Devices for Myopia: This quality improvement study assesses the optical output and safety classification of 4 commercially available red light therapy devices for myopia management using American National… #Ophthalmology #Eyecare #JAMA

Corneal Abrasion Leading to Stromal Melt in a Patient With Myopia This case report describes an incidence of corneal melt in a patient with a history of corneal insert implantation 26 years prior due to myopia.

Ophthopedia Update: Corneal Abrasion Leading to Stromal Melt in a Patient With Myopia: This case report describes an incidence of corneal melt in a patient with a history of corneal insert implantation 26 years prior due to myopia. #Ophthalmology #Eyecare #JAMA

Relative Risk of Neovascular Age-Related Macular Degeneration Following Cataract Surgery This cohort study examines the association between cataract surgery and progression of age-related macular degeneration in adults 60 years or older.

Ophthopedia Update: Relative Risk of Neovascular Age-Related Macular Degeneration Following Cataract Surgery: This cohort study examines the association between cataract surgery and progression of age-related macular degeneration in adults 60 years or older. #Ophthalmology #Eyecare #JAMA

As a medical school professor, I was taught to treat obesity and cancer as separate problems.

That was wrong.

A major new JAMA review confirms obesity drives 12... jamanetwork.com/journals/jama/article-ab...

#ObesityAndCancer #MetabolicHealth #JAMA #CancerPrevention #WeightLoss

Chinese Sweeties unlocked 🤩 have yall tried these? #hakka #chinese #jama... youtube.com/shorts/IlBQu... via @YouTube

The Politics and Policies Against US Children This Viewpoint discusses how the policy changes in the One Big Beautiful Bill Act will harm US children.

An opinion piece by #physicians sounding the alarm over #childrenshealthcare under Tr*mp. #bigbeautifulbill #healthcare #medicine #medicaid #medicalcare #pediatricians #calltoaction #jama
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For non-Medical laymen, British medical journal #Lancet is as prestigious and authoritative as #NewEnglandJournalofMedicine , both more so than #JAMA, often cited by commercial ads.
#ThanksKennedy #ThanksTrump

JAMA Ophthalmology Mission Statement: To be the indispensable source of ophthalmic knowledge by promptly publishing innovative, clinically relevant research through consistent and authoritative peer review and, thereby, to be the first choice of authors for their important manuscripts.

Ophthopedia Update: JAMA Ophthalmology: Mission Statement: To be the indispensable source of ophthalmic knowledge by promptly publishing innovative, clinically relevant research through consistent and authoritative peer review and, thereby, to be the first choice of… #Ophthalmology #Eyecare #JAMA

Unmasking a Masquerade of Ocular Dysgenesis A 66-year-old man had nebulomacular corneal opacities, iris atrophy, and corectopia along with coarse facial skin, resorbed digits, anesthetic patches, and healed trophic skin ulcers. What would you do next?

Ophthopedia Update: Unmasking a Masquerade of Ocular Dysgenesis: A 66-year-old man had nebulomacular corneal opacities, iris atrophy, and corectopia along with coarse facial skin, resorbed digits, anesthetic patches, and healed trophic skin ulcers. What would you do… #Ophthalmology #Eyecare #JAMA

Pediatric Orbital MALT Lymphoma Masquerading as a Pyogenic Granuloma This case report discusses a diagnosis of B-cell lymphoma mucosa-associated lymphoid tissue (MALT) in the conjunctiva of a young boy who presented with a painless, enlarging conjunctival mass.

Ophthopedia Update: Pediatric Orbital MALT Lymphoma Masquerading as a Pyogenic Granuloma: This case report discusses a diagnosis of B-cell lymphoma mucosa-associated lymphoid tissue (MALT) in the conjunctiva of a young boy who presented with a painless, enlarging… #Ophthalmology #Eyecare #JAMA

Ophthalmology Residency Match Rates by Applicant Demographics This cohort study assesses patterns in medical school students who matched with ophthalmology residency programs from 2021 to 2023, according to candidates’ sex, race, and ethnicity.

Ophthopedia Update: Ophthalmology Residency Match Rates by Applicant Demographics: This cohort study assesses patterns in medical school students who matched with ophthalmology residency programs from 2021 to 2023, according to candidates’ sex, race, and ethnicity. #Ophthalmology #Eyecare #JAMA

Influence of Intraocular Pressure on Clinical Decision-Making in Glaucoma Management This cohort study using data from the Sight Outcomes Research Collaborative (SOURCE) data repository assesses how intraocular pressure levels influence the decision to initiate or escalate glaucoma therapy in clinical practice.

Ophthopedia Update: Influence of Intraocular Pressure on Clinical Decision-Making in Glaucoma Management: This cohort study using data from the Sight Outcomes Research Collaborative (SOURCE) data repository assesses how intraocular pressure levels influence the… #Ophthalmology #Eyecare #JAMA

Proteomic Profile in Retinopathy of Prematurity This secondary analysis of the Mega Donna Mega (MDM) randomized clinical trial investigated if early longitudinal changes in proteomic profiles in extremely preterm infants are associated with the development of severe retinopathy of prematurity.

Ophthopedia Update: Proteomic Profile in Retinopathy of Prematurity: This secondary analysis of the Mega Donna Mega (MDM) randomized clinical trial investigated if early longitudinal changes in proteomic profiles in extremely preterm infants are associated with the… #Ophthalmology #Eyecare #JAMA

Iris-Derived Central Corneal Neovascularization in Peters Anomaly This case report describes a case of Peters anomaly with central corneal neovascularization diagnosed in a female toddler who presented with acute intracorneal hemorrhage in the right eye.

Ophthopedia Update: Iris-Derived Central Corneal Neovascularization in Peters Anomaly: This case report describes a case of Peters anomaly with central corneal neovascularization diagnosed in a female toddler who presented with acute intracorneal hemorrhage in the… #Ophthalmology #Eyecare #JAMA

The Global Epidemiologic Transition of Retinopathy of Prematurity Retinopathy of prematurity (ROP) remains one of the leading causes of preventable childhood blindness, arising at the intersection of neonatal survival gains and uneven health system capacity to safeguard visual outcomes. In this issue of JAMA Ophthalmology, Wong and colleagues present a timely global analysis using data from the Global Burden of Disease 2021 study, integrating socioeconomic and health care indicators with machine-learning models to forecast ROP-related visual impairment through 2050. Their findings reveal an apparent paradox: while the global burden of ROP-related blindness has declined, prevalence is rising in middle- and upper-middle-income regions. Rather than indicating regression, this pattern reflects a turning point in the global evolution of neonatal care—when advances in neonatal survival outpace the development of screening, follow-up, and rehabilitation systems. Viewing these shifts through a health-system lens provides crucial insight into how global progress can be sustained without deepening inequities.

Ophthopedia Update: The Global Epidemiologic Transition of Retinopathy of Prematurity: Retinopathy of prematurity (ROP) remains one of the leading causes of preventable childhood blindness, arising at the intersection of neonatal survival gains and uneven health… #Ophthalmology #Eyecare #JAMA

Resolving Complex Retinal Alleles via Long-Read Sequencing This case report discusses how long-read sequencing enables phasing and complements clinical testing to provide a complete genetic diagnosis in TYR-associated oculocutaneous albinism.

Ophthopedia Update: Resolving Complex Retinal Alleles via Long-Read Sequencing: This case report discusses how long-read sequencing enables phasing and complements clinical testing to provide a complete genetic diagnosis in TYR-associated oculocutaneous albinism. #Ophthalmology #Eyecare #JAMA

Global and Regional Trends in Retinopathy of Prematurity This cross-sectional study examines global trends in retinopathy of prematurity−related visual impairment and identifies risk factors for increased prevalence of visual loss.

Ophthopedia Update: Global and Regional Trends in Retinopathy of Prematurity: This cross-sectional study examines global trends in retinopathy of prematurity−related visual impairment and identifies risk factors for increased prevalence of visual loss. #Ophthalmology #Eyecare #JAMA

This is the font from which my meager hope arises these days…as I watch (self and) friends age and sicken and even die —
— I remember that med sci keeps pushing forward 🏆
#JAMA
#Medsky
#oncosky

Global Cardiology Societies Team Up to Address Environmental Stressors This Medical News article discusses a new joint statement from the American College of Cardiology, the American Heart Association, the European Society of Cardiology, and the World Heart Federation ad...

Great comment in #JAMA #Cardiology concerning the joint paper of the #cardiovascular #societies dealing with #environmental #stressors and #cardiovascular #disease
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It took me twenty years of reading every word of #ScientificAmerican to finally see through their deceptions. Moving on to #Nature I could see the lies quite easily #AIDS #BigBang #Covid Watch out #JAMA here I come.