Perfect for our first post: big collaborate effort spearheaded by Masahiro Onji showing how sex hormones and RANK regulate gut expansion during reproduction 🤰🤱

Very nice coculture system from @lionellb.bsky.social 's lab! T cells form Crohn's Disease patients induce cell death when cocultured with autologous #organoids even after days of organoid subculture, imparing stem cell proliferation and affecting differentiation. #Gastrosky #immunology 🧪

Can I be added?

Please, I’d like to be added.

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Yes, please!

Happy to transition to this platform to discuss science and share our fascination.

The movie below shows a dendritic cell, highlighting the remarkable ability of immune cells to navigate their cell body and to organise their intracellular cargo (nucleus in cyan).

(Kroll et al, EMBO J 2023)

Even though there are great #devbio and #biophysics starter packs, I felt #morphogenesis & #organogenesis was missing as a subfield :D

Far from complete or full. Tell me if you want to be added!
go.bsky.app/PB6s8PQ

I’d like to be added, please.

I’d like to be added, please.

May I too? thanks a lot!

Thanks, would love to be added too.

Mast cell–derived BH4 and serotonin are critical mediators of postoperative pain Mast cells and their BH4-serotonin metabolic axis are critical drivers of postoperative pain hypersensitivity in mice.

Proud to share our latest paper in Science Immunology
- how #mastcell -derived #BH4/#serotonin drives postoperative pain in mice, revealing a potential therapeutic target for surgical pain:

scim.ag/87H