The accompanying cover (that has its own story for anothet time!), as daily dose of nostalgia in my office. 🪰🧬

Parafibromin/Hyrax Activates Wnt/Wg Target Gene Transcription by Direct Association with β-catenin/Armadillo The Wnt pathway controls cell fates, tissue homeostasis, and cancer. Its activation entails the association of β-catenin with nuclear TCF/LEF proteins…

#OTD 20 (!) years ago - the first paper from my thesis work came out. Feels like yesterday.

Great memories with George Hausmann and Koni Basler. From a time when new Wnt pathway components could still be found - thx to Drosophila!

Onwards, always.

www.sciencedirect.com/science/arti...

Significant differences are indicated with 🐦‍⬛

Today's #MobileOfficeView while F1 is cycling through the foothills.
#PILife #AlwaysBeWriting

Pancreatic cancer mRNA vaccine shows lasting results in an early trial Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later.

"Pancreatic cancer mRNA vaccine shows lasting results in an early trial: Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later."

I'm very sorry to tell you that Dr. Ellen LeMosy passed away after a short illness this past Thursday.

This is her sister. Ellen will be sorely missed.

Friends! My university is hiring an Asst Professor of Biology and an Asst Professor of History and American Indian Studies. Our students are wonderful, my colleagues are great, we do good work. Please share! Happy to answer questions :)

heritage.edu/wp-content/u...

heritage.edu/wp-content/u...

I'm looking for #NewPIs (<3 years as lab heads) in the gene regulation/functional genomics space. If you are one or know one, please comment below! 🧪

A form, a bracketed rectangle with movable type carefully laid out in rows of varying sizes. Stolen from a Medium article: "The original movable type. Image source: Flickr, purdman1"

Hot off the presses!
Some people think I'm a stereotype of a nerd 🤓, but isn't that kind of a cliché?

Let's talk about how "stereotype" & "cliché" were invented by the printing press.

Movable type depended on typesetters putting little letter blocks (a 'sort' or 'type') in 'forms'.

May your smoke alarms be always working.
May your dog be always happy.
May your fire extinguisher be always accessible.
May your ladder be always on a firm, flat surface.
May your cat be around.

Digitalis purpurea, or the common foxglove, displays vibrant bell-shaped petals and is the natural source of the cardiac drug digoxin.

Foxglove plants evolved a mammalian-like cholesterol-to-steroid conversion pathway that synthesized cardenolides by mimicking mammals’ endocrine signaling axis.

Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/4vr7Ndj

A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

Good thing the symposium's swag fits the weather!

Ja but unfortunately we had this of sorts all winter....need the water here!!!

Colorado doing Colorardo things ❄️🏔🌨:

Happening today @cuanschutz.bsky.social - our training program's symposium while a snow storm rages outside. Oddly metaphoric.
(...and yes...that is a left-handed DNA...)
#devbio #diseasemodels #PILife #GraduateSchool 🧪

As it should. It's amazing how we ever get to do any research with all that is going on. Keep going!

Congrats!

A mugshot registration photograph from Auschwitz. A man with a shaved head wearing a striped uniform photographed in three positions (profile and front with bare head and a photo with a slightly turned head with a hat on). The prisoner number is visible on a marking board on the left.

17 April 1906 | A Polish Jew, Samuel Gross, was born in Krakow. An assembly worker.

In #Auschwitz from 18 May 1942.
No. 34705
He perished in the camp on 27 July 1942.
---

📖 Jewish prisoners at KL Auschwitz: https://lekcja.auschwitz.org/29_zydzi_en/

Large Monstera leaf of a mature plant with multiple rows of fenestrations

Speckled variegated monstera with wild white-green mosaicism.

Variegated Monstera leaf of a juvenile cutting with half of the leaf fully white.

Another leaf of the plant shown in the previous pic, half the leaf is white.

Meanwhile, near a south-facing window in CO:
#Monstera 🌱

Finally published at long last (at least in the pre-view version). Explore the wild and woolly world of archaeal histones! Interactive archaeal histone graph incluced rdcu.be/fdFjv. Congratulations to first author Shawn Laursen

Today in "Lateral Plate Mesoderm is beautiful":
#devbio #NotEverythingIsNeuralCrest #MesodermStillRocks

Spectral multiplexing is typically limited to 4-5 channels. Our new preprint introduces a framework that utilizes DNA barcoding and signal tuning to enable robust spectral unmixing and ground-truth benchmarking to achieve 15-plex subcellular profiling without cycling
www.biorxiv.org/content/10.6...

A black-and-white historical photograph of Elizabeth Bugie, a pioneering biochemist, working in a laboratory. She is shown from the waist up, wearing a short-sleeved white top and focusing intently on her work. She has dark, shoulder-length hair and is holding a piece of glassware connected to a black rubber tube, seemingly adjusting a filtration or distillation setup. Several Erlenmeyer flasks and glass funnels sit on the bench in front of her. In the background, shelves are filled with numerous glass chemical bottles of various sizes, and a window with multiple panes is visible to the right.

Biochemist Elizabeth Bugie co-discovered streptomycin (with Selman Waksman), the first antibiotic against Mycobacterium tuberculosis.

Waksman went on to win the 1952 Nobel Prize for Medicine & took full credit for the discovery. Bugie died #OTD in 2001. #WomenInSTEM #MatildaEffect (1/2)

Whole organism 3D mapping reveals universal branching topology and biophysical optimization governs vascular and nervous system development

Read about our work here: www.biorxiv.org/content/10.6...

View of a misty sunrise over the gate of the former Auschwitz II-Birkenau camp. In the foreground, stones and wooden parts of the railway line are visible.

Memory comes in many forms.
Here it is in your hands.

On this #YomHaShoah, we ask you to amplify our voice.

Learn about the history of Auschwitz:

Lessons: lesson.auschwitz.org
Podcast: podcast.auschwitz.org
Videos: youtube.com/auschwitzmemorial

Support our mission & share this post.

Examples of the new model organism shirts for sale on the SDB merchandise website

Excited to share that @socdevbio.bsky.social has a new and improved merch store! Rep your fav model organism in one of the Society’s new original designs 🤗 sdb-official-merch.printify.me

The 'reward' for staying in science for 14yr is equipment you bought as a new PI is failing...-80 freezer recommendations?

**Old unit was 570L capacity (fits 3 labs, so 4-5 shelves) ideally comes with metal racks (or can be purchased).

Also, in this economy, is there an 'old PI' discount? 😅

I mean...🍕

And I don't even need AI!