The small protein cryo-EM paper I helped start has been accepted in Nature Communications - what a relief. Thanks to @landerlab.bsky.social and @olibclarke.bsky.social for their constructive review. Congratulations to all co-authors, and wishing everyone good luck.
www.nature.com/articles/s41...
Prefusion-specific glycoprotein B human antibodies protect against neonatal HSV-2 infection pubmed.ncbi.nlm.nih.gov/41929215/ #cryoEM
Nature research paper: Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor
go.nature.com/4urU3yb
Incredible
cc @capitalweather.bsky.social
Ok got to a better spot
We have both sundogs, a full halo, and an inverted halo!
Incredibly rare - don't think I've ever seen the inverted before
@capitalweather.bsky.social
Images of molecular models of ALG3 and ALG9 proteins with substates bound.
I’m very excited to share some newly published work that uncovers the molecular basis for oligomannose synthesis!
www.nature.com/articles/s41...
In 75-79 year olds in UK, the RSV Pre-F vaccine remains highly effective in the real world. 82.3% vaccine effectiveness against hospitalization due to RSV-associated acute respiratory infection and 86.7% effectiveness against severe disease requiring oxygen
www.thelancet.com/journals/lan...
Since last year, I've been making a RELION GUI that supports viewing, navigating and running jobs in a way completely compatible with the original RELION pipeline. Now it's working nicely for both SPA and tomography! Please try it out - github.com/hanjinliu/hi...
The wwPDB just hit a major milestone: 𝟏𝟎,𝟎𝟎𝟎 𝐄𝐌𝐃𝐁 𝐞𝐧𝐭𝐫𝐢𝐞𝐬 𝐫𝐞𝐥𝐞𝐚𝐬𝐞𝐝 𝐢𝐧 𝐚 𝐬𝐢𝐧𝐠𝐥𝐞 𝐲𝐞𝐚𝐫. To put this in context, the entire EMDB reached 10,000 entries total in 2019 — now the archive 𝐡𝐚𝐬 𝐬𝐮𝐫𝐩𝐚𝐬𝐬𝐞𝐝 𝟓𝟎,𝟎𝟎𝟎. Huge credit to the community driving 3DEM forward!
www.wwpdb.org/news/news?ye...
#3DEM #EMDB
Structure and immunogenicity of an engineered soluble prefusion-stabilized EBV gB antigen pubmed.ncbi.nlm.nih.gov/41484092/ #cryoEM
De novo design of protein nanoparticles with integrated functional motifs www.biorxiv.org/content/10.64898/2025.12.19.695620v1 #cryoEM
An integrated workflow for structural virology with a 100 keV electron microscope www.biorxiv.org/content/10.64898/2025.12.08.693081v1 #cryoEM
How can AI and #cryoEM help save some of the biggest babies on the planet? 🐘🔬
Our new preprint identifies Elephant Herpesvirus gH/gL/gO as a receptor-binding complex and a promising vaccine candidate, now being tested in young elephants across European zoos! 💉
www.biorxiv.org/content/10.6...
CryoET of microbes inside an animal organ? Yes it’s possible! Check out our new preprint showing how we did it! What an amazing collaboration with amazing scientists who made this possible!
This is an interesting case of a patient from Chad infected with a novel arenavirus species/variant/strain, presenting with meningoencephalitis.
IMO, could be classified as a highly divergent Lassa virus strain in a new country (similar to what Togo has observed).
www.nejm.org/doi/10.1056/...
Delighted to share the peer-reviewed version of our article describing a prefusion-stabilized MARV GP vaccine immunogen and a best-in-class MARV neutralizing and protective antibody!
Led by @aminaddetia.bsky.social with @virbiotechnology.bsky.social
@hhmi.org
www.nature.com/articles/s41...
🧪 🦠 Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B www.nature.com/articles/s41...
Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action pubmed.ncbi.nlm.nih.gov/41184282/ #cryoEM
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Structural Mechanism of Prestin-Membrane Mechanotransduction www.biorxiv.org/content/10.1101/2025.10....
HKU25 clade MERS-related coronaviruses use ACE2 as a functional receptor pubmed.ncbi.nlm.nih.gov/41168429/ #cryoEM
Genetic diversity in horseshoe bat ACE2 and sarbecovirus spike proteins mutually shape one another www.biorxiv.org/content/10.1101/2025.10....
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
journals.plos.org/plospathogen...
Applying computational design, researchers in #ScienceTranslationalMedicine present an integrated vaccine platform that combines the strengths of mRNA and nanoparticle technologies, and show it elicits strong immune responses in a SARS-CoV-2 model system. https://scim.ag/3W9M09p
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
Really excited to have been a small part of this work investigating sarbecovirus host range, receptor usage and antigenicity!
www.biorxiv.org/content/10.1101/2025.09.03.673949v1
New preprint! If some merbecoviruses use DPP4 and others use ACE2, what do those hedgehog merbecoviruses use?! As it turns out, neither! In our latest study, we uncover the "missing" receptor for the MERS-related viruses in hedgehogs. [These findings were first shared at ASV this year] (1/6)
