I remember when you posted about this last year!!! Amazing the research office just repeated their old error. Sorry that you have to go through this, again

Laboratory Head in Biomedical Data Science Job in Melbourne VIC - SEEK Lead a biomedical data science lab, secure funding, publish research and collaborate globally to drive impactful cardiometabolic outcomes.

We are recruiting a PI in biomedical data science at @bakerresearchau.bsky.social in Melbourne!

A fantastic opportunity and do get in touch if any q's! www.seek.com.au/job/91619982...

a video game character is holding a sword and standing next to a woman . Alt: Cloud vs Sephiroth

Lars Fischer vs DB (colorised, 2026)

This reads like something a neonazi 21 year old with a 12 follower substack posts, not the partner of governments (including my native Germany). It's 2026 why am I even surprised

Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze!

www.science.org/doi/10.1126/...

I feel like there shouldn't be a single user (account) associated with AI rewritten code. The original prompt writer will disappear, so others should be able to port software updates into the AI rewrite without barriers. In AI rewrites, no one is responsible by default

Absolute banger:

"find that metaSPAdes consistently outperforms MEGAHIT"

"Binning refinement, which combines bins from multiple different algorithms, leads to reduced performance"

"We further show that CheckM2 systematically overestimates completeness and underestimates contamination"

Naming a product famously based on stolen IP 'rosalind' is certainly a choice. Can you imagine the company culture that thinks this won't be an issue

This would be a fun paper! How much negative and positive selection occurs per day across all kingdoms of life?

a cartoon character in a suit and tie stands in front of a fire escape Alt: Skinner saying am I out of touch

I don't know who that is

Parallel processing in purrr 1.1.0 The functional programming toolkit for R gains new capabilities for parallel processing and distributed computing using mirai.

native parallel processing with purrr! tidyverse.org/blog/2025/07...

I feel like the longer you stay in academia, the less hireable you get for "other" bioinfo jobs. Industry/NGO professionalises, adds more for-pay tools academics never see (no exp.). Academia instead focuses more and more on writing ever longer grants/papers as funding dwindles. returns are marginal

Ooh which concert??

Just got my credit card bill and with all living costs exploding (AGAIN) life is difficult, difficult, lemon-difficult

GALBA2 walks into the arena. We rewrote our protein-based genome annotation pipeline in Snakemake.

Give it a genome + proteins from close relatives → get gene predictions. No RNA-Seq, no GeneMark needed.

miniprot → AUGUSTUS, fully containerised, HPC-ready.

github.com/Gaius-Augustus/GALBA2

I'll come to cattle next :D kinda nice when almost every "participant" has been genotyped

PYC Therapeutics here in Perth, drug development in clinical and preclinical stages

Working for 3 months in for-profit bioinformatics now - what a change in gears! Definitely much more fast-paced environment, with not much tolerance for error. Almost too much daily context switching. Hard problems, but lots of room for solutions and ideas and pushing. This is good

Helicopter carrying a car

I took the kids to the Beverley Air Show, and among all the loop-di-loops stunt plane flights, they had a helicopter drop a car from the sky. It was as awesome as that sounds like

Metabuli & Metabuli App v1.2 improve novel species classification with higher precision and recall. New light mode is 1.8× faster and requires 50% less storage while keeping precision. New RefSeq, GTDB, HRGM, and HROM databases added.
💾 github.com/steineggerla...
📄 doi.org/10.64898/2026.03.13.711249

Sequence Display generates large-scale protein sequence–activity datasets by simultaneously reading out the sequence of interest and a downstream editing efficiency - perfect for data hungry ML methods!

Happy to have played a small part in this!

Good news, everyone! I thought I had a possum living in my roof, which isn't easy to fix: possums are protected & territorial animals, which means they won't move and need help.
But i just saw what's living in the roof, and it's just the fattest rat I've ever seen. Yay, that's an invasive species!

Estimating Organism Abundance Using Within‐Sample Haplotype Frequencies of eDNA Data Environmental DNA (eDNA) provides powerful insights into species presence and community composition but remains limited in its capacity to infer species abundance or population structure. Here, we sh...

🧬 My haplotype paper is out!

We show that deviations between within-sample and population-level haplotype frequencies can be used to estimate how many individuals contributed to an eDNA sample.

No tissue references needed, just metabarcoding data and some population genetics.

#eDNA #PopGen

I've recently had it write tests for some calculation functions and it just kept on changing the expected output number until tests passed :D very relatable

Unironically, Claude is writing those too :P

🚨New preprint and our results are rather concerning..

We find the "boiling frog" equivalent of AI use. Using large-scale RCTs, we provide *casual* evidence that AI assistance reduces persistence and hurts independent performance.

And these effects emerge after just 10–15 minutes of AI use!

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“Most large companies are spending more time strategizing against their employees than against their competitors.” 🖐️🎤

remarkable how fast things went from 'rewrite everything in Rust!!!' to 'rewrite everything in Rust using Claude!!!'

What’s next: Quarto 2 – Quarto We’ve started working on quarto-dev/q2, a full rewrite of Quarto in Rust.

And another Quarto announcement; I've alluded to it before, but we're making it "official".

We've started work on Quarto 2. The blog post has an overview: quarto.org/docs/blog/po...

We'll share more in future blog posts, but here's what you can expect from the Quarto 2 dev effort:

(1/)

We've learned nothing from the Wu-Tang Clan